1989
DOI: 10.1128/aac.33.1.82
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Pharmacokinetics of single- and multiple-dose teicoplanin in healthy volunteers

Abstract: Teicoplanin, an investigational glycopeptide antibiotic related chemically and microbiologically to vancomycin, has in vitro and in vivo activity against gram-positive aerobic and anaerobic bacteria. We compared the single-and multiple-dose pharmacokinetics of intravenous teicoplanin in healthy volunteers. Serum and urine samples were collected for 35 days after single-dose (3 mg/kg) and 72 days after multiple-dose (3 mg/kg per day for 21 days) administration. A three-exponent equation with zero-order input wa… Show more

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Cited by 40 publications
(21 citation statements)
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“…DISCUSSION Perhaps the greatest source of disagreement relative to teicoplanin pharmacokinetics has been the issue of the terminal-phase half-life. Values for this parameter have ranged from approximately 32 to as high as 176 h; the latter value was from a multiple-dose (3 mg/kg per dose) study conducted at our institution (4,16). The terminal-phase half-life in the present study, 157 h, was consistent with our previous value (4).…”
Section: Methodssupporting
confidence: 82%
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“…DISCUSSION Perhaps the greatest source of disagreement relative to teicoplanin pharmacokinetics has been the issue of the terminal-phase half-life. Values for this parameter have ranged from approximately 32 to as high as 176 h; the latter value was from a multiple-dose (3 mg/kg per dose) study conducted at our institution (4,16). The terminal-phase half-life in the present study, 157 h, was consistent with our previous value (4).…”
Section: Methodssupporting
confidence: 82%
“…Although statistically significant (P < 0.05), the magnitude of this difference was quite small and probably negligible. The CLT obtained in this study was similar to, but slightly greater than, the CLT of 0.175 ml/min/kg determined previously by our group (4). Because the value of CLT in the present study was larger, this difference is not consistent with dose-dependent nonlinear elimination and in all likelihood represents variability between the subject groups.…”
Section: Methodscontrasting
confidence: 55%
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