Pharmacokinetics of slow‐release preparations of sodium valproate

Yamatogi, Yasuko; Yoshinaga, Harumi; Oka, Eiji; Ohtahara, Shunsuke; Yamashita, Syoichi; Furuno, Katsushi; GOMITA, Yutaka

doi:10.1111/j.1440-1819.1995.tb01909.x

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Factors Influencing Serum Drug Concentrations1

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2004

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“…To compensate for the short half‐life of VPA, its slow‐release form (VPA‐R) has been widely used, with prolonged T max by the gradual dissolution keeping the same AUC. As some granule type VPA‐R may dissolve faster in a high humidity, they should be carefully storaged so as to maintain their sustained release properties 7 . Twice‐a‐day administration of VPA‐R minimizes serum level variations with lowered C max and elevated C min , but once‐a‐day VPA‐R enlarges serum variation with lowered C max and C min , compared with twice‐a‐day VPA.…”

Section: Factors Influencing Serum Drug Concentrationsmentioning

confidence: 99%

Principles of antiepileptic drug treatment of epilepsy

Yamatogi

2004

Psychiatry Clin Neurosci

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For the successful treatment of epilepsy, accurate diagnosis of epilepsy and epileptic seizures, and proper selection of antiepileptic drugs (AED) according to the classification of epileptic syndromes are fundamentally important. Efficacy of AED treatment, however, depends not only on its pharmacological action but also on its efficient use, namely a rationally thinking tailor-made treatment considering the characteristics of each patients, i.e. individual differences in pharmacokinetics, factors influencing AED concentrations, AED interactions, and comprehensively their life style and psychosocial factors.

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Section: Factors Influencing Serum Drug Concentrationsmentioning

confidence: 99%