Pharmacokinetics of streptomycin in Ethiopian children with tuberculosis and of different nutritional status

Bolme, Per; Eriksson, Margareta; Habte, Demissie; Paalzow, Lennart

doi:10.1007/bf00542504

Cited by 11 publications

(17 citation statements)

References 7 publications

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“…This was in contrast to a separate study that documented a significant decrease in the total CL and a corresponding significant increase in the t½ of penicillin in children with kwashiorkor only [47]. There was no influence of PEM on the total clearance of the three aminoglycoside antibiotics studied [41,48,50,52]. One of these studies involving streptomycin documented an increased plasma half-life in children with kwashiorkor but no change in children who were underweight or had marasmus only [48].…”

Section: Page 32 Of 52 European Journal Of Clinical Pharmacologycontrasting

confidence: 52%

“…A separate study where the degree of malnutrition was undefined showed no effect of PEM on the Vd of theophylline [22]. In the case of streptomycin, children with kwashiorkor exhibited an increased Vd [48] whereas children with marasmus or underweight had a decreased Vd [48]. A decreased Vd for quinine in children with undefined PEM in one study [51] was in contrast to a separate study involving children with marasmus and marasmic-kwashiorkor where the Vd was unaffected [21].…”

Section: Protein Binding and Distributionmentioning

confidence: 53%

“…PEM appears not to affect the total clearance of most drugs primarily eliminated by the kidneys as their values remained almost unchanged in the subjects and controls [16,41,48,50,52]. This was probably because most of these drugs are rarely metabolised as they are known to be eliminated unchanged via the kidneys [61].…”

Section: Discussionmentioning

confidence: 80%

“…There was no influence of PEM on the total clearance of the three aminoglycoside antibiotics studied [41,48,50,52]. One of these studies involving streptomycin documented an increased plasma half-life in children with kwashiorkor but no change in children who were underweight or had marasmus only [48]. This was probably as a result of presence of oedema in kwashiorkor which enhances the volume of distribution of streptomycin.…”

Section: Protein Binding and Distributionmentioning

confidence: 91%

“…The volume of distribution (Vd) of 13 drugs was evaluated in 19 studies (Table 3) [16,18,19,21,22,[40][41][42][43][44][45][46][47][48][49][50][51][52]. There were contrasting results for four drugs (gentamicin, quinine, streptomycin and theophylline).…”

Section: Protein Binding and Distributionmentioning

confidence: 99%

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A systematic review of pharmacokinetics studies in children with protein-energy malnutrition

Oshikoya

Sammons

Choonara

2010

Eur J Clin Pharmacol

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Section: Page 32 Of 52 European Journal Of Clinical Pharmacologycontrasting

confidence: 52%

Section: Protein Binding and Distributionmentioning

confidence: 53%

Section: Discussionmentioning

confidence: 80%

Section: Protein Binding and Distributionmentioning

confidence: 91%

Section: Protein Binding and Distributionmentioning

confidence: 99%

See 3 more Smart Citations

A systematic review of pharmacokinetics studies in children with protein-energy malnutrition

Oshikoya

Sammons

Choonara

2010

Eur J Clin Pharmacol

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Pharmacokinetic changes in drugs during protein-calorie malnutrition: correlation between drug metabolism and hepatic microsomal cytochrome p450 isozymes

2004

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The rats with protein-calorie malnutrition (PCM, 5% casein diet for a period of 4-week) were reported to exhibit 60 and 80% suppression in the hepatic microsomal cytochrome P450 (CYP) 1A2 and CYP2C11 levels, respectively, and 40-50% decreases in CYP2E1 and CYP3A1/2 levels compared to control (23% casein diet for a period of 4-week) based on Western blot analysis. In addition, Northern blot analysis showed that CYP1A2, CYP2E1, CYP2C11, and CYP3A1/2 mRNAs decreased in the state of PCM as well. Hence, pharmacokinetic changes of the drugs in rats with PCM [especially the area under the plasma concentration-time curve from time zero to time infinity (AUC) changes of metabolite(s)] reported from literatures were tried to explain in terms of CYP isozyme changes in the rats. Otherwise, the time-averaged nonrenal clearance (CL NR) of parent drug was compared. Pharmacokinetic changes of the drugs in other types of malnutritional state, such as kwashiorkor and marasmus, in both human and animal models were also compared. The drugs reviewed are as follows: diuretics, antibiotics, anticancer agents, antiepileptics, antiarrythmics, analgesics, xanthines, antimalarials, and miscellaneous.

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Influence of Malnutrition on the Pharmacokinetics of Drugs Used in the Treatment of Poverty-Related Diseases: A Systematic Review

et al. 2021

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Background Patients affected by poverty-related infectious diseases (PRDs) are disproportionally affected by malnutrition. To optimize treatment of patients affected by PRDs, we aimed to assess the influence of malnutrition associated with PRDs on drug pharmacokinetics, by way of a systematic review. Methods A systematic review was performed on the effects of malnourishment on the pharmacokinetics of drugs to treat PRDs, including HIV, tuberculosis, malaria, and neglected tropical diseases. ResultsIn 21/29 PRD drugs included in this review, pharmacokinetics were affected by malnutrition. Effects were heterogeneous, but trends were observed for specific classes of drugs and different types and degrees of malnutrition. Bioavailability of lumefantrine, sulfadoxine, pyrimethamine, lopinavir, and efavirenz was decreased in severely malnourished patients, but increased for the P-glycoprotein substrates abacavir, saquinavir, nevirapine, and ivermectin. Distribution volume was decreased for the lipophilic drugs isoniazid, chloroquine, and nevirapine, and the α1-acid glycoprotein-bound drugs quinine, rifabutin, and saquinavir. Distribution volume was increased for the hydrophilic drug streptomycin and the albumin-bound drugs rifampicin, lopinavir, and efavirenz. Drug elimination was decreased for isoniazid, chloroquine, quinine, zidovudine, saquinavir, and streptomycin, but increased for the albumin-bound drugs quinine, chloroquine, rifampicin, lopinavir, efavirenz, and ethambutol. Clinically relevant effects were mainly observed in severely malnourished and kwashiorkor patients. Conclusions Malnutrition-related effects on pharmacokinetics potentially affect treatment response, particularly for severe malnutrition or kwashiorkor. However, pharmacokinetic knowledge is lacking for specific populations, especially patients with neglected tropical diseases and severe malnutrition. To optimize treatment in these neglected subpopulations, adequate pharmacokinetic studies are needed, including severely malnourished or kwashiorkor patients.

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Pharmacokinetics of streptomycin in Ethiopian children with tuberculosis and of different nutritional status

Cited by 11 publications

References 7 publications

A systematic review of pharmacokinetics studies in children with protein-energy malnutrition

A systematic review of pharmacokinetics studies in children with protein-energy malnutrition

Pharmacokinetic changes in drugs during protein-calorie malnutrition: correlation between drug metabolism and hepatic microsomal cytochrome p450 isozymes

Influence of Malnutrition on the Pharmacokinetics of Drugs Used in the Treatment of Poverty-Related Diseases: A Systematic Review

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