Pharmacokinetics of subcutaneous and intramuscular butorphanol in dogs

Pfeffer, Morris; Smyth, Robert D.; Pittman, Kenneth A.; Nardella, Pasqua A.

doi:10.1002/jps.2600690715

Cited by 59 publications

(35 citation statements)

References 6 publications

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“…It is worth to report that the DTM-NLF combination produced a profound balanced anesthesia for clinical cases introduced to our hospital for castration and wound suturing and didn't required any additional anesthesia techniques (non-published data). Regarding the rapid onset of DTM-BTR was attributed to fast absorption of BTR, as the author findings refer to non-significant difference in the pharmacokinetics of subcutaneous and intramuscular butorphanol injection in dogs (Pfeffer, et al, 1980). Combining NLF with DTM resulted in potent sedative and analgesic effect as well and these finding was similar to those reported after NLFxylazine combination in dogs (Lester et al, 2003), the same authors stated that the NLF-sedative combination resulted in more potent effect than its combination with acepromazine (tranquilizer), and this confirm the weak and short sedative and analgesic effect of NLF-DZP in the current study.…”

Section: Resultsmentioning

confidence: 92%

Comparison of the Antinociceptive Potentiating Effect of Two Opioids when Combined with Detomidine or Diazepam in Dogs

Abu-Ahmed¹

2017

AJVS

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Key words:Balanced anesthesia, detomidine, nalbuphine, butorphanol, dog.The continuous search for suitable and effective drug combination for dog sedation and analgesia is an aim for most of researchers. The current experimental study aimed to evaluate and compare the sedative, analgesic and cardiorespiratory effects of detomidine/butorphanol, detomidine/nalbuphine, diazepam/butorphanol and diazepam/nalbuphine combinations in sex healthy mongrel dogs. Detomidinebutorphanol or nalbuphine resulted in deep degree of sedation and a reliable period of intense antinociceptive effect. The Longest period of sedation was recorded post diazepam-butorphanol injection. However, diazepam-nalbuphine resulted in the shortest period of both sedation and antinociception. Significant reduction of pulse and respiratory rates was observed post detomidine-opioids combination while diazepamopioids combination resulted in minimal cardiorespiratory effect. It could be concluded that detomidine-butorphanol induced a strong preemptive antinociceptive effect and a state of balanced anesthesia with minimal response to noxious stimulation.

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Section: Resultsmentioning

confidence: 92%

Comparison of the Antinociceptive Potentiating Effect of Two Opioids when Combined with Detomidine or Diazepam in Dogs

Abu-Ahmed¹

2017

AJVS

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“…Butorphanol is a mixed opioid agonist/antagonist (Pachter and Evens 1985) with quite a good analgesic effect (Pfeffer et al 1980). It induces weak sedation, with a minimum negative impact on the cardiovascular system.…”

Section: Tiletaminementioning

confidence: 99%

Changes of Vital Parameters after Administration of Butorphanol during Tiletamine-Zolazepam-Ketamine-Xylazine Anaesthesia for Joint Surgery in Miniature Pigs

et al. 2008

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The study compares the effects of butorphanol in pigs undergoing joint surgery in tiletamine-zolazepam-ketamine-xylazine (TKX) anaesthesia. A total of 12 pigs were divided into 2 groups by 6 animals -BUT (anaesthetized with TKX combination and butorphanol) and CON (control group -anaesthetized with TKX combination only). All pigs were sedated with a mix of tiletamin-zolazepam-ketamin-xylazin, put into total anaesthesia using propofol, and connected to an anaesthesiology unit (O 2 -Air). For 40 min we logged the heart rate (HR), respiratory rate (RR), mean arterial pressure (MAP), haemoglobin saturation by oxygen (SpO 2 ) and end-tidal CO 2 concentration (ETCO 2 ) values. Ten minutes after connecting to the devices, the pigs in the BUT group were intravenously administered butorphanol (0.2 mg/kg) in the total volume of 2 ml, or physiological saline in the same volume. The pigs in the BUT group had a lower (p < 0.

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“…Zoletil in various combinations with other anaesthetics has no significant effect on vital functions (Rauser et al, 2008). For example, in minipigs under tiletamine-zolazepam-ketamine-xylazine anaesthesia or after the addition of butorphanol (mixed opioid agonist/antagonist [Pachter and Evens 1985]) to achieve a favourable analgesic effect (Pfeffer et al 1980) did not produce significant effects on heart rate, respiratory rate, mean arterial pressure, haemoglobin saturation by oxygen and end-tidal CO 2 concentration. In dogs, a slight hypothermia and increase in respiration and heart rate has been observed after administration of zoletil (Sarma et al, 1998).…”

Section: Introductionmentioning

confidence: 98%

Zoletil anaesthesia in chronobiological studies

Švorc

Bačová

Nováková

et al. 2015

Biological Rhythm Research

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Zoletil anaesthesia does not affect vital functions; however, there is no literature evidence regarding the effect of zoletil anaesthesia on the circadian rhythm(s) of vital functions. The aims of the present study, with respect to dependence on the light-dark (LD) cycle under in vivo conditions in spontaneously breathing zoletil-anaesthetized rats were to assess ECG parameters that may to predict development of ventricular arrhythmias and to assess arterial acid-base balance, which have the direct impact on the heart electrophysiology. The experiment was performed using zoletil-anaesthetized (30mg/kg,i.p) female Wistar rats after adaptation to LD cycle (12h:12h). LD differences were found in heart rate, rectal temperature, electrophysiological myocardial parameters and acid-base balance. Animals were in systemic acidosis, hypoxia and hypercapnia in the both lightet periods of the regimen day. These results suggest that zoletil can be used in chronobiological studies investigating in vivo electrophysiological myocardial properties in rat models.

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Pharmacokinetics of subcutaneous and intramuscular butorphanol in dogs

Cited by 59 publications

References 6 publications

Comparison of the Antinociceptive Potentiating Effect of Two Opioids when Combined with Detomidine or Diazepam in Dogs

Comparison of the Antinociceptive Potentiating Effect of Two Opioids when Combined with Detomidine or Diazepam in Dogs

Changes of Vital Parameters after Administration of Butorphanol during Tiletamine-Zolazepam-Ketamine-Xylazine Anaesthesia for Joint Surgery in Miniature Pigs

Zoletil anaesthesia in chronobiological studies

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