Pharmacokinetics of three doses of once-weekly fluconazole (150, 300, and 450 mg) in distal subungual onychomycosis of the toenail

Rich, Phoebe; Scher, Richard K.; Breneman, Debra; Savin, Ronald C.; Feingold, David Stuart; Konnikov, Nellie; Shupack, Jerome L.; Pinnell, Sheldon R.; Levine, Norman; Lowe, Nicholas J.; Aly, Raza; Odom, Richard B.; Greer, Donald L.; Morman, Manuel R.; Bucko, A; Tschen, Eduardo; Elewski, Boni E.; Smith, Edgar B.; Hilbert, James

doi:10.1016/s0190-9622(98)70493-1

Cited by 36 publications

(28 citation statements)

References 19 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…The adverse effects occurred in 6 (12%) patients. This is in line with previous reports where the percentage of patients with side effects from the treatment with FLZ ranged from 1% to 10% (5,8,9).…”

Section: Discussionsupporting

confidence: 93%

See 1 more Smart Citation

Efficacy of Fluconazole at a 400 mg Weekly Dose for the Treatment of Onychomycosis

Hryncewicz-Gwóźdź¹,

Plomer-Niezgoda²,

Kalinowska³

et al. 2015

Acta Derm Venerol

View full text Add to dashboard Cite

show abstract

Section: Discussionsupporting

confidence: 93%

“…It accumulates in the stratum corneum, hair and nails, and is present in the therapeutic concentration at 4 or even 6 months post-treatment. Additionally, FLZ is a relatively safe drug with well-described interactions and side effects (3)(4)(5)(6).…”

mentioning

confidence: 99%

Efficacy of Fluconazole at a 400 mg Weekly Dose for the Treatment of Onychomycosis

Hryncewicz-Gwóźdź¹,

Plomer-Niezgoda²,

Kalinowska³

et al. 2015

Acta Derm Venerol

View full text Add to dashboard Cite

show abstract

“…The mean concentration of fluconazole in healthy nails was 3.09 pg/gm after 1 month of therapy and this increased to 8.54 pg/gm after 6 months of treatment. There may be a slower uptake of drug into diseased nails [155] Six months after stopping fluconazole the concentration in healthy and diseased toenails was still 1.4 and 1.9 Fg/gm, respectively [154]. The plasma half-life of fluconazole is, mean -+ standard deviation, 31 * 4 h; this is sufficiently long to permit once-daily dosing [156].…”

Section: Fluconazolementioning

confidence: 99%

“…In a study for the treatment of dermatophyte toe nail onychomycosis, fluconazole 150,300 and 450 mg was administered once weekly for a maximum of 12 months [155,158] The median time to steady state concentration in toenails (healthy, affected) in the three treatment groups was: 150 mg (5, 6.5) months, 300 mg (5, 6) months and 450 mg (4, 7) months, respectively [155]. The elimination half-life of fluconazole in healthy toenails ranged from 2 to 3 months; for affected toenails the corresponding range was 2-4 months.…”

Section: Fluconazolementioning

confidence: 99%

The new oral antifungal agents for onychomycosis of the toenails

Gupta

Shear

1999

Acad Dermatol Venereol

View full text Add to dashboard Cite

Itraconazole, terbinafine and fluconazole have been used approximately 100 million times to treat superficial mycoses. These agents are more effective than the traditional antimycotics for the treatment of pedal onychomycosis; furthermore, the new agents have a broader spectrum of action than griseofulvin. In general, itraconazole, terbinafine and fluconazole have a favorable adverse-effects profile with drug interactions that are usually predictable and manageable. The new oral antifungal agents have a high benefit-to-risk ratio when used to treat toenail onychomycosis.

show abstract

“…Fluconazole is a potent triazole antifungal agent, very effective in treatment of onychomycoses [2][3][4]. However, it is underused in systemic treatment of the disease due to its numerous drug interactions and side-effects [5] as well as heightened susceptibility for development of fungal resistance.…”

Section: Introductionmentioning

confidence: 99%

Simple, Inexpensive and Ecologically Friendly Derivative Spectrophotometric Fluconazole Assay from Nail Lacquer Formulations

Elezović¹,

Elezovic²,

Hadzović³

2011

AJAC

View full text Add to dashboard Cite

Nail lacquers represent new drug form specifically designed to treat infected nail plate. They are complex organic solutions with specific assaying problems due to the high content of the polymer and plasticizer. Furthermore, there is a lack of assaying methods of active substances from this type of formulations in scientific literature. We developed derivative UV-spectrophotometric method for determination of fluconazole content in antifungal nail lacquer formulations. The method was validated for specificity, linearity, precision (repeatability), intermediate precision and accuracy (recovery). The method is specific, linear in the range of 99.53 -497.65 μg/ml, precise and showed good recovery (98.79% -101.77% from all six developed formulations). Besides, it is inexpensive, simple and nontoxic, i.e. ecologically acceptable. This method can be used for assaying fluconazole from this type of formulations.

show abstract

Pharmacokinetics of three doses of once-weekly fluconazole (150, 300, and 450 mg) in distal subungual onychomycosis of the toenail

Cited by 36 publications

References 19 publications

Efficacy of Fluconazole at a 400 mg Weekly Dose for the Treatment of Onychomycosis

Efficacy of Fluconazole at a 400 mg Weekly Dose for the Treatment of Onychomycosis

The new oral antifungal agents for onychomycosis of the toenails

Simple, Inexpensive and Ecologically Friendly Derivative Spectrophotometric Fluconazole Assay from Nail Lacquer Formulations

Contact Info

Product

Resources

About