Pharmacokinetics/pharmacodynamics of levofloxacin 750mg once daily in young women with acute uncomplicated pyelonephritis

Nicolle, Lindsay E.; Duckworth, Heather; Sitar, D. S.; Bryski, Lisa; Harding, G. K. M.; Zhanel, George G.

doi:10.1016/j.ijantimicag.2007.10.021

Cited by 12 publications

(4 citation statements)

References 8 publications

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“…In case of levofloxacin, the C max and AUC 0-infinity was lower than the findings of the previous study, 56-57 which might be due to dissimilar study population and different dose used. 58 The plasma half-life (t 1/2 ) was similar to that of previous study, 47,48,56 though the peak serum concentration was attained little earlier (T max ) in the present study in comparison to previous reports. 45,59 In case of gatifloxacin, the C max and AUC 0-infinity was similar to the findings of the previous studies.…”

Section: Resultssupporting

confidence: 90%

Pharmacokinetic study after single oral dose of beta-lactam and fluoroquinolone antimicrobials in Bangladeshi healthy male volunteers

Chowdhury

Islam

Rahman

2014

Bangladesh J Physiol Pharmacol

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The variability of response to antimicrobial has been inadequately explained because of lack of pharmacokinetic data. The present pharmacokinetic study was designed to provide information beneficial to formulate a population pharmacokinetic model appropriate for Bangladeshi population. Among the beta-lactams, amoxicillin (500 mg), flucloxacillin (250 mg), cefuroxime (500 mg) and among the fluoroquinolones, ciprofloxacin (500 mg), levofloxacin (500 mg), gatifloxacin (400 mg) were studied in 15 healthy Bangladeshi male volunteers. The Cmax, AUC0infinity, Tmax, T1/2 and Ctrough were studied with all antimicrobials. Later, the Cmax and AUC0infinity were adjusted for bodyweight and dose. Among the studied antimicrobials, the Cmax varied to great extent even after adjustment for bodyweight and dose. The Cmax after adjustment was highest in case of flucloxacillin and lowest in case of ciprofloxacin, indicating excellent absorption of flucloxacillin in Bangladeshi population. The information obtained through this study generates necessity of new cut-off value for the antimicrobials.DOI: http://dx.doi.org/10.3329/bjpp.v30i1.20789 Bangladesh J Physiol Pharmacol 2014; 30(1):16-24

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Section: Resultssupporting

confidence: 90%

Pharmacokinetic study after single oral dose of beta-lactam and fluoroquinolone antimicrobials in Bangladeshi healthy male volunteers

Chowdhury

Islam

Rahman

2014

Bangladesh J Physiol Pharmacol

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“…Isolates obtained from the urinary tract had ciprofloxacin MICs ranging from susceptible to resistant (≤0.06 µg/mL to 8 µg/mL). For the treatment of lower urinary tract infections, because the fluoroquinolones ciprofloxacin and levofloxacin attain very high concentrations in the urine (eg, approximately 300 µg/mL), these high concentrations may theoretically overcome E coli with reduced susceptibility or even resistance to fluoroquinolones (21). However, because fluoroquinolone MICs are known to be elevated in acidic urine (pH approximately 5.5 versus broth at approximately 7.2), and the concern that strains with a firststep QRDR mutation or PMQR determinants may rapidly develop resistance on therapy, we would not recommend fluoroquinolone therapy for urinary infections or any other infections due to E coli with known fluoroquinolone-resistance determinants.…”

Section: Discussionmentioning

confidence: 99%

Mechanisms of Reduced Susceptibility to Ciprofloxacin in Escherichia coli Isolates from Canadian Hospitals

Baudry-Simner

Singh²,

Karlowsky

et al. 2012

Canadian Journal of Infectious Diseases and Medical Microbiolog

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“…The good results of the latter may arise from its pharmacokinetics and pharmacodynamics. 41 The results from research on antimicrobial resistance, with an excellent outcome for ciprofloxacin, along with previous reports, 42 encourage maintaining quinolones as recommended treatment for UTIs. A 7 -day quinolone regimen is the current standard.…”

Section: Ethical Approvalmentioning

confidence: 87%

Urinary tract infections in postmenopausal women with type 2 diabetes: clinical correlates and quinolone susceptibility

Borowczyk¹,

Chmielarz-Czarnocińska²,

Faner-Szczepańska³

et al. 2017

Polish Archives of Internal Medicine

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INTRODUCTION Diabetes mellitus and the postmenopausal period are associated with increased risk of urinary tract infections (UTIs) in women. However, data on UTIs in postmenopausal diabetic women are scarce. OBJECTIVES The aim of this study was to determine the prevalence of UTIs in postmenopausal women with type 2 diabetes mellitus, identify the potential risk factors, describe the causative pathogens, and assess their susceptibility to quinolones. PATIENTS AND METHODS Patients were interviewed, examined, and had their hospital records analyzed. An uncontaminated midstream urine sample was collected and cultured in selective or enriched media. Colony‑forming units were counted and susceptibility to quinolones was assessed. Univariate and multivariate logistic regression models were built. RESULTS Forty women were included in this prospective cross‑sectional study; their median age was 64 years (range, 52-84 years). UTIs occurred in 37.5% of the patients. The major implicated pathogens were Escherichia coli (66.7%) and enterococci (20%; most often Enterococcus faecalis). Most of the pathogens (93.8%) were susceptible to all tested quinolones. Patients with UTIs had a significantly lower glomerular filtration rate (P = 0.008) and higher comorbidity index (P = 0.01) compared with patients with sterile urine. Microangiopathic complications, including retinopathy and nephropathy, were identified as independent risk factor for UTIs (adjusted odds ratio, 3.5; 95% CI, 1.2-5.5; P = 0.006). The other clinical correlates of UTIs were urinary incontinence, hyperlipidemia, and microalbuminuria. CONCLUSIONS Postmenopausal diabetic patients with microangiopathy are at high risk of UTIs and therefore should be educated and vigilantly monitored. Attention should also be paid to urinary incontinence, hyperlipidemia, and microalbuminuria as other risk factors for UTIs. Quinolones are an attractive treatment option in this group of patients in Poland.

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Pharmacokinetics/pharmacodynamics of levofloxacin 750mg once daily in young women with acute uncomplicated pyelonephritis

Cited by 12 publications

References 8 publications

Pharmacokinetic study after single oral dose of beta-lactam and fluoroquinolone antimicrobials in Bangladeshi healthy male volunteers

Pharmacokinetic study after single oral dose of beta-lactam and fluoroquinolone antimicrobials in Bangladeshi healthy male volunteers

Mechanisms of Reduced Susceptibility to Ciprofloxacin in Escherichia coli Isolates from Canadian Hospitals

Urinary tract infections in postmenopausal women with type 2 diabetes: clinical correlates and quinolone susceptibility

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