Pharmacologic Aspects of Aging: Additional Literature

Bender, A. Douglas

doi:10.1111/j.1532-5415.1967.tb05339.x

Cited by 5 publications

(4 citation statements)

References 28 publications

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“…These results may be related to the decreased ratio of liver weight to body weight and probably a possible decrease in the rate of hepa tic blood flow in the old mice (14)(15)(16). On the other hand, there was no marked age difference in the toxicity of strychnine.…”

Section: Discussionmentioning

confidence: 99%

“…On the other hand, there was no marked age difference in the toxicity of strychnine. The reason for the lack of the age difference is not yet clear but the decrease in the sensitivity of the central nervous system to strychnine in the old mice may be a possible factor (15,17).…”

Section: Discussionmentioning

confidence: 99%

“…There are some papers which demonstrate the differences of the drug effect and toxicity in aged subject from these in young one in animal experiments and in clinics (1,3,(14)(15)(16).…”

Section: Discussionmentioning

confidence: 99%

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Studies on Age Difference in Mice for the Activity of Drug-Metabolizing Enzymes of Liver Microsomes

Kato

Takanaka

Onoda

1970

Japanese Journal of Pharmacology

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In previous papers, we reported that the activity of drug-metabolizing enzymes was higher in young female rats than in old female rats and that the duration of hexo barbital anesthesia was shorter in the young females than in the old females (1-3). More over, it was observed that the induction of microsomal drug-metabolizing enzymes by phenobarbital was more effective in young rats than in old rats (4,5).In the present communication, we wish to report the evidence that, in contrast to the results obtained with rats, clear age difference was not observed in the activity of drug-metabolizing enzymes in mice and there was no clear age difference in the induc tion of drug-metabolizing enzymes by phenobarbital. MATERIALS AND METHODSMale mice of ICR strain were used, unless otherwise specified. Phenobarbital (80 mg/kg) was given intraperitoneally 48 and 24 hours before sacrifice. Pooled liver from 3 mice was used for the preparation of each homogenate. Preparation of post mitochondrial and microsomal fractions was carried out as described in a previous paper (6). The activity of drug-metabolizing enzymes of liver microsomes was assayed as described in the previous paper (6). The hydroxylation of hexobarbital was determined by measuring the disappearance of the substrate according to the method of Cooper and Brodie (7). The N-demethylation of aminopyrine was determined by the forma tion of 4-aminoantipyrine (La Du et al.) (8). The hydroxylation of aniline was deter mined by the formation of p-aminophenol according to the method described by Kato and Gillette (9). The nitroreduction of p-nitrobenzoic acid was determined by measur ing the p-aminobenzoic acid formed according to the method of Fouts and Brodie (10). NADPH-cytochrome c reductase was determined according to the method of Williams and Kamin (11). NADPH-neotetrazolium reductase was assayed as described in the previous paper (2). The contents of microsomal protein and cytochrome P-450 were determined by the method of Lowry et al. (12) and Omura and Sato (13), respective ly. The duration of hexobarbital anesthesia and zoxazolamine paralysis was determined by the loss of the righting reflex. Strychnine toxicity was evaluated by the convulsion rate and mortality.

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Section: Discussionmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

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Studies on Age Difference in Mice for the Activity of Drug-Metabolizing Enzymes of Liver Microsomes

Kato

Takanaka

Onoda

1970

Japanese Journal of Pharmacology

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“…If renal function is diminished so that potassium excretion is impaired, hyperkalemia can be induced. All of these effects are possible in all patients, but the less labile elderly are more susceptible, and the effects potentially are more lethal (14).…”

Section: Drug Dictamentioning

confidence: 99%

Some Principles of Medication in Geriatrics*

Freeman

1974

J American Geriatrics Society

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In geriatrics, inappropriate and incorrect use of drugs is reflected in a higher percentage of untoward effects. Most reactions are identified readily but some are lost in the induced disturbances of physiologic balance that occur more readily in the aged. Improper dosage, injudicious methods of administration, and lack of awareness of drug interactions are common and are associated with failure to quantitate the reactive capacities of aging body resources. The paucity of didactic instruction and the difficulty which aged patients encounter in observing a medical regimen add to the problems of therapy. The fact that aging alters drug effects and that drug effects alter senescent functions emphasizes the need to be familiar with the roster of confirmed pharmacologic data. Observance of such regulations would improve treatment of the individual patient. Medication schedules must be in line with recognized levels of normality in senescence. These precautions will reduce the chances of initiating primary or sequential mishaps when drugs are administered to the elderly who are more susceptible to side effects and less likely to be responsive to reparative measures.

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Aging Animal Models for the Study of Drug–Nutrient Interactions

Newberne

1986

Nutrition &Amp; Aging

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Pharmacologic Aspects of Aging: Additional Literature

Cited by 5 publications

References 28 publications

Studies on Age Difference in Mice for the Activity of Drug-Metabolizing Enzymes of Liver Microsomes

Studies on Age Difference in Mice for the Activity of Drug-Metabolizing Enzymes of Liver Microsomes

Some Principles of Medication in Geriatrics*

Aging Animal Models for the Study of Drug–Nutrient Interactions

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