Pharmacologic interventions for the prevention and treatment of retinopathy of prematurity

Beharry, Kay D.; Valencia, Gloria; Lazzaro, Douglas R.; Aranda, Jacob V.

doi:10.1053/j.semperi.2015.12.006

Cited by 56 publications

(41 citation statements)

References 249 publications

(193 reference statements)

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“…Additionally, Indomethacin increases the risk of ROP by 1.5 times. There are conflicting reports with regards to the association between ROP and the use of surfactant [73]. Additional studies are needed to illustrate this relationship.…”

Section: Retinopathy Of Prematurity (Rop)mentioning

confidence: 99%

Section: Retinopathy Of Prematurity (Rop)mentioning

confidence: 99%

“…There is a growing body of evidence that no single therapy has proven to be effective and safe in preventing and treating ROP [73,76]. Managing ROP effectively necessitates coordination between physicians from different disciplines, such as neonatologists, obstetricians, and ophthalmologists.…”

Section: Retinopathy Of Prematurity (Rop)mentioning

confidence: 99%

“…Monitoring oxygen therapy and avoiding intermittent hypoxia have been shown as the cornerstone factors in preventing ROP. Refractory errors, retinal detachment and recurrent ROP are the most common complications of ROP [73][74][75].Retinopathy of Prematurity, to a great extent, is a preventable disease, so introducing strict qualified standards of neonatal care, such as restricted supervised oxygen use for preterm and screening program for early detection and treatment of ROP would be effective in reducing its incidence thus its consequences.There are many medications that have been reported to induce ROP. The duration of steroid use increases the incidence of ROP, therefore the use of postnatal Dexamethasone has been restricted.…”

mentioning

confidence: 99%

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The First Sixty Minutes in Preterm Neonates’ Life: Predicted Morbidities and Interventions

El-Atawi¹

2018

JPNC

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Preterm neonates are more vulnerable to many diseases and complications than full-term infants as most of their biological systems are still underdeveloped. Fortunately, most of these morbidities are preventable as there are many interventions that could be performed in the first 60 minutes of neonatal life to avoid them and their long-term consequences, thus rightfully defining 'the golden hour'. The objective of this article is to review the potential morbidities that neonates might experience and understand their mechanisms, risk factors and its possible outcomes. We also reviewed the possible actions that could be implemented during the golden hour to prevent these morbidities and investigated their effectiveness. Medline and Cochrane database for systematic review were the main two electronic database that we used to search for studies. Studies pertaining to morbidities, such as hypothermia, hypoglycemia, respiratory distress, intraventricular hemorrhage (IVH), Chronic lung disease (CLD) and retinopathy of prematurity (ROP) have been selected according to their full text accessibility for us. Reports related to possible interventions that could be performed to prevent these morbidities have also been involved that include but not only restricted to drying & head coverings, polyethylene occlusive skin wraps, ambient room temperature, pre-warmed incubator, heated humidified gases, heated mattress and skin-to-skin contact for hypothermia; dextrose infusion pump, dextrose burette and oral dextrose for hypoglycemia; indomethacin, ibuprofen, antithrombin and heparin for IVH; surfactant and CPAP for respiratory distress; controlling oxygen saturation for ROP. Keywords: The First Sixty Minutes in Preterm Neonates' Life: Predicted Morbidities and Interventions 2/8Copyright: ©2018 El-Atawi et al. the relation between severe hypothermia (<32°C) and shortand long-term neurodevelopmental outcomes are required. Moderate hypothermia was found to be associated with severe intraventricular hemorrhage, intraventricular leukomalacia, and necrotizing enterocolitis. Yet, these associations should be analyzed carefully since they were based on studies with a wide confidence interval. More studies with larger sample size are warranted to accurately illustrate these associations [5]. Moreover, hypothermia increases oxygen consumption, thus leading to hypoxia and subsequently pulmonary vasoconstriction which, in turn, declines surfactant production and worsens respiratory distress. The presence of comorbidities with hypothermia increases the fatality rate, so adding a higher category to the severity of hypothermia would represent an effective addition to the WHO classification of the severity of hypothermia [8].Large surface area of neonates in relation to their small body weight makes them more vulnerable to hypothermia than fullterm babies. Preterm neonates have a higher transepidermal water loss than term due to their immature epidermal layer [9]. Their premature vasomotor control which acts as a thermoregulatory mec...

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Section: Retinopathy Of Prematurity (Rop)mentioning

confidence: 99%

Section: Retinopathy Of Prematurity (Rop)mentioning

confidence: 99%

Section: Retinopathy Of Prematurity (Rop)mentioning

confidence: 99%

mentioning

confidence: 99%

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The First Sixty Minutes in Preterm Neonates’ Life: Predicted Morbidities and Interventions

El-Atawi¹

2018

JPNC

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“…DR, a major cause of vision impairment in working adults, affects ∼93 million worldwide [1], including vision-threatening diabetic macular edema (DME) with retinal leakage and proliferative DR (PDR) with retinal neovascularization (RNV). ROP is the most common cause of vision loss in children, affecting ∼14,000 – 16,000 preterm infants each year in the U.S. [2]. Similar to PDR, ROP in preterm neonates is characterized by RNV [3].…”

Section: Introductionmentioning

confidence: 99%

Pathogenic role and therapeutic potential of pleiotrophin in mouse models of ocular vascular disease

et al. 2017

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Angiogenic factors play an important role in the pathogenesis of diabetic retinopathy (DR), neovascular age-related macular degeneration (nAMD) and retinopathy of prematurity (ROP). Pleiotrophin, a well-known angiogenic factor, was recently reported to be upregulated in the vitreous fluid of patients with proliferative DR (PDR). However, its pathogenic role and therapeutic potential in ocular vascular diseases have not been defined in vivo. Here using corneal pocket assays, we demonstrated that pleiotrophin induced angiogenesis in vivo. To investigate the pathological role of pleiotrophin we used neutralizing antibody to block its function in multiple in vivo models of ocular vascular diseases. In a mouse model of DR, intravitreal injection of pleiotrophin-neutralizing antibody alleviated diabetic retinal vascular leakage. In a mouse model of oxygen-induced retinopathy (OIR), which is a surrogate model of ROP and PDR, we demonstrated that intravitreal injection of anti-pleiotrophin antibody prevented OIR-induced pathological retinal neovascularization and aberrant vessel tufts. Finally, pleiotrophin-neutralizing antibody ameliorated laser-induced choroidal neovascularization, a mouse model of nAMD, suggesting that pleiotrophin is involved in choroidal vascular disease. These findings suggest that pleiotrophin plays an important role in the pathogenesis of DR with retinal vascular leakage, ROP with retinal neovascularization and nAMD with choroidal neovascularization. The results also support pleiotrophin as a promising target for anti-angiogenic therapy.

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Bone marrow mesenchymal stem cells modified by angiogenin‐1 promotes tissue repair in mice with oxygen‐induced retinopathy of prematurity by promoting retinal stem cell proliferation and differentiation

Liu

Meng

et al. 2019

Journal Cellular Physiology

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Retinopathy has become one of the major factors that lead to blindness worldwide.Although many clinical therapies are concerned about such disease, most of them focus on symptoms alleviation. In this study, we aim to investigate whether coculture retinal stem cells (RSCs) with bone marrow mesenchymal stem cells transfected with angiogenin-1 (Ang-1-BMSCs) affects the damaged retinal tissue of oxygen-induced retinopathy of prematurity (OIR-ROP) mice. After OIR-ROP mouse model establishment, Ang-1-BMSCs, RSCs, and OIR-ROP retinal tissues were cocultured in a a transwell chamber. RSCs proliferation and the expression of Ang-1, insulin-like growth factor-1 (IGF-1) in the supernatant of RSCs, as well as β-tubulin and protein kinase C (PKC) expression were evaluated. Finally, the repair of OIR-ROP mice retinal tissues was observed by injecting Ang-1-BMSCs + RSCs. In the OIR-ROP mouse model, RSCs cocultured with OIR-ROP retinal tissues could be induced to differentiate into cells expressing β-tubulin and PKC and promote the expression of Ang-1 and IGF-1. coculture of Ang-1-BMSCs further enhanced the proliferation and differentiation of RSCs by promoting the expression of Ang-1 and IGF-1. Coculture of RSCs + Ang-1-BMSCs induced differentiation of Ang-1-BMSCs through interaction among intercellular factors and restored the damaged retinal tissue of OIR-ROP mice. Collectively, our study provided evidence that coculture of Ang-1-BMSCs and RSCs could promote the proliferation and differentiation of RSCs and improve the treatment for the damaged retina tissue of OIR-ROP mice. K E Y W O R D S angiogenin-1, bone mesenchymal stem cells, coculture, differentiation, oxygen-induced retinopathy, proliferation, retinal stem cells, retinopathy of prematurity

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Pharmacologic interventions for the prevention and treatment of retinopathy of prematurity

Cited by 56 publications

References 249 publications

The First Sixty Minutes in Preterm Neonates’ Life: Predicted Morbidities and Interventions

The First Sixty Minutes in Preterm Neonates’ Life: Predicted Morbidities and Interventions

Pathogenic role and therapeutic potential of pleiotrophin in mouse models of ocular vascular disease

Bone marrow mesenchymal stem cells modified by angiogenin‐1 promotes tissue repair in mice with oxygen‐induced retinopathy of prematurity by promoting retinal stem cell proliferation and differentiation

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