2013
DOI: 10.1016/j.jcjd.2013.01.021
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Pharmacologic Management of Type 2 Diabetes

Abstract: If glycemic targets are not achieved within 2 to 3 months of lifestyle management, antihyperglycemic pharmacotherapy should be initiated. Timely adjustments to, and/or additions of, antihyperglycemic agents should be made to attain target glycated hemoglobin (A1C) within 3 to 6 months. In patients with marked hyperglycemia (A1C 8.5%), antihyperglycemic agents should be initiated concomitantly with lifestyle management, and consideration should be given to initiating combination therapy with 2 agents, 1 of whic… Show more

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Cited by 122 publications
(60 citation statements)
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References 109 publications
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“…Additionally, treatment regimens should include medications that involve less risk of hypoglycemia when food access is unpredictable [57]. For example, Metformin and DPP-4 inhibitors involve a very low risk of hypoglycemia when used alone [68]. For patients requiring insulin, regimens that allow for as much flexibility (such as multiple daily injections with basal and bolus insulin) can allow patients to omit doses if meals are missed, reducing the risk of hypoglycemia [69].…”
Section: Medications and Reducing Hypoglycemic Episodesmentioning
confidence: 99%
“…Additionally, treatment regimens should include medications that involve less risk of hypoglycemia when food access is unpredictable [57]. For example, Metformin and DPP-4 inhibitors involve a very low risk of hypoglycemia when used alone [68]. For patients requiring insulin, regimens that allow for as much flexibility (such as multiple daily injections with basal and bolus insulin) can allow patients to omit doses if meals are missed, reducing the risk of hypoglycemia [69].…”
Section: Medications and Reducing Hypoglycemic Episodesmentioning
confidence: 99%
“…1) (24). Presentation of diabetes with ketonuria, with or without marked symptoms, should raise the suspicion of type 1 diabetes, although the possibility of accelerated lipolysis and ketogenesis due to starvation also deserves consideration.…”
Section: When Should Insulin Therapy Be Started?mentioning
confidence: 99%
“…1). Some guidelines suggest insulin is indicated for HbA 1c >69 mmol/mol (>8.5%) at diagnosis (24). This approach is not well substantiated by evidence, but it clearly can help by reducing glucose toxicity.…”
Section: When Should Insulin Therapy Be Started?mentioning
confidence: 99%
“…Pharmacists who have active diabetes practices lead these sessions and the content is consistent with current guideline recommendations and training material provided to patients who are starting insulin. 3,14,15 The session runs for 50 minutes with a ratio of 8 students to 1 pharmacist in each session. Students are encouraged to attempt at least one blood glucose check and mock insulin injection while they are directly supervised by the pharmacists.…”
Section: Methodsmentioning
confidence: 99%