Pharmacologic Modulation of Picryl Chloride-Induced Contact Dermatitis in the Mouse

Lavaud, Philippe; Rodrigue, F.; Carré, C.; Touvay, Caroline; Mencia‐Huerta, Jean‐Michel; Braquet, P.

doi:10.1111/1523-1747.ep12478438

Cited by 18 publications

(9 citation statements)

References 13 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…In the PiCl-induced delayed-type inflammatory model, histamine is involved in edema formation in the early phase (2 h) [34] but almost certainly not in the late phase [24]. On the other hand, in the repeated application model, the immediate-type response is augmented [3, 6] via the increased number of mast cells [5], and histamine participates in edema formation and scratch behavior [23].…”

Section: Discussionmentioning

confidence: 99%

Modification of the Picryl Chloride-Induced Allergic Dermatitis Model in Mouse Ear Lobes by 12-<i>O</i>-Tetradecanoylphorbol 13-Acetate, and Analysis of the Role of Histamine in the Modified Model

Hirasawa

Ohsawa

Katoh

et al. 2008

Int Arch Allergy Immunol

View full text Add to dashboard Cite

Background: In atopic dermatitis, inflammation induced by antigen-nonspecific stimuli further enhances the allergic inflammation. However, there is no experimental model in which allergic dermatitis is evoked where the inflammation has been induced by antigen-nonspecific stimuli. Here, we established a novel dermatitis model in mice and analyzed the role of histamine. Methods: After sensitization with picryl chloride (PiCl) by painting on ear lobes of cyclophosphamide-treated mice, 12-O-tetradecanoylphorbol 13-acetate (TPA) was painted twice at the same site, and then allergic inflammation was induced by painting PiCl. Histamine antagonists and cyclosporine A (CsA) were administered intravenously. Results: The application of TPA shifted the PiCl-induced allergic inflammation from a delayed-type response to a biphasic response, increased the infiltration of eosinophils and mast cells at the inflammatory site, shifted the cytokine milieu from Th1 to Th2 and induced the expression of thymic stromal lymphopoietin in the ear lobes. The PiCl-induced increase in the thickness of the ear lobe in the immediate phase was suppressed by the H1 antagonist pyrilamine. In contrast, the increase in the swelling in the late phase and the infiltration of eosinophils were suppressed by the H3/H4 antagonist thioperamide. The inhibitory effect of the combined treatment with pyrilamine and thioperamide on the TPA-modified contact dermatitis was as potent as that of CsA. Conclusion: Induction of the antigen-nonspecific inflammation by TPA enhanced the PiCl-induced allergic inflammation. Histamine plays significant roles in the early-phase swelling via H1 receptors, and the late-phase swelling via H3/H4 receptors in this TPA-modified allergic dermatitis model.

show abstract

Section: Discussionmentioning

confidence: 99%

Modification of the Picryl Chloride-Induced Allergic Dermatitis Model in Mouse Ear Lobes by 12-<i>O</i>-Tetradecanoylphorbol 13-Acetate, and Analysis of the Role of Histamine in the Modified Model

Hirasawa

Ohsawa

Katoh

et al. 2008

Int Arch Allergy Immunol

View full text Add to dashboard Cite

show abstract

“…The ear-swelling response according to the mouse model for type I allergy was evaluated by the method reported by Lavaud et al 15) with some modifications. Mice were intravenously sensitized by 2 g of anti-TNP IgE in a 0.1% BSA-phosphate-buffered saline (PBS) solution.…”

Section: Methodsmentioning

confidence: 99%

Anti-allergic Activity of Naringenin Chalcone from a Tomato Skin Extract

Yamamoto¹,

Yoshimura²,

Yamaguchi³

et al. 2004

Bioscience, Biotechnology, and Biochemistry

151

View full text Add to dashboard Cite

“…The Th1 response is enhanced in order to suppress IgE production in humans, and autoimmune diseases may be initiated by this increased Th1 response. Examining the PCA reaction is a standard method used to measure allergen-specific IgE levels in mouse allergy models (19) and for evaluating the suppression of mast cell degranulation by anti-allergic drugs and orally administered compounds (12,13). We used mouse ear swelling assays for IgE-dependent allergic inflammation to examine whether LABs, like some polyphenols from citrus foods and tea leaves, can reduce inflammation.…”

Section: Discussionmentioning

confidence: 99%

“…The IgE-mediated hypersensitivity reaction was evaluated according to a previous method (12,13). After preliminary breeding for 13 days, 5-week-old female BALB/c mice were divided into 6 groups.…”

Section: Ige-mediated Hypersensitivity Reactionmentioning

confidence: 99%

Anti-allergic effect of lactic acid bacteria isolated from seed mash used for brewing sake is not dependent on the total IgE levels

Masuda¹,

Takahashi²,

Yoshida

et al. 2012

Journal of Bioscience and Bioengineering

View full text Add to dashboard Cite

Pharmacologic Modulation of Picryl Chloride-Induced Contact Dermatitis in the Mouse

Cited by 18 publications

References 13 publications

Modification of the Picryl Chloride-Induced Allergic Dermatitis Model in Mouse Ear Lobes by 12-<i>O</i>-Tetradecanoylphorbol 13-Acetate, and Analysis of the Role of Histamine in the Modified Model

Modification of the Picryl Chloride-Induced Allergic Dermatitis Model in Mouse Ear Lobes by 12-<i>O</i>-Tetradecanoylphorbol 13-Acetate, and Analysis of the Role of Histamine in the Modified Model

Anti-allergic Activity of Naringenin Chalcone from a Tomato Skin Extract

Anti-allergic effect of lactic acid bacteria isolated from seed mash used for brewing sake is not dependent on the total IgE levels

Contact Info

Product

Resources

About