Pharmacological activities and molecular mechanisms of pure and crude extract of Andrographis paniculata: An update

Mehta, Sharuti; Sharma, Anil Kumar; Singh, Rajesh

doi:10.1016/j.phyplu.2021.100085

Cited by 26 publications

(13 citation statements)

References 116 publications

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“…These data strengthen the previous hypothesis that sulfation is likely one of the major metabolic pathways for AP biotransformation in rats (Ye et al, 2011). In addition, other research studies indicate that the compound is metabolized not only in the liver but also in the intestine, including the duodenum, jejunum, and probably the terminal ileum or colon as well (Mehta et al, 2021). This finding involves the effect of first-pass metabolism, which reflects its low oral bioavailability, decreasing the concentration of AP before it enters the blood circulation (Ye et al, 2011).…”

Section: Metabolismsupporting

confidence: 89%

“…Another minor contributor to the low bioavailability could be the expression of P-glycoprotein (P-gp), an efflux transporter, which limits the cellular uptake of xenobiotics. The effect of the competition between AP and other drugs on P-gp-mediated efflux needs to be considered, as co-administration with other medicines could possibly result in a drug interaction that could change the pharmacokinetics and pharmacological therapeutic effects (Mehta et al, 2021).…”

Section: Metabolismmentioning

confidence: 99%

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A comprehensive review on disposition kinetics and dosage of oral administration of Andrographis paniculata, an alternative herbal medicine, in co-treatment of coronavirus disease

Songvut

Suriyo²,

Panomvana³

et al. 2022

Front. Pharmacol.

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Coronavirus disease 2019 (COVID-19) is a present global health crisis that is driving the investigation of alternative phytomedicines for antiviral purposes. The evidence suggests that Andrographis paniculata crude or extract is a promising candidate for treating symptoms of severe acute respiratory syndrome coronavirus 2 (SARS-CoV-2). This review aims to consolidate the available reports on the disposition kinetics of andrographolide, a main active component of A. paniculata. The second objective of this review is to summarize the available reports on an appropriate oral dosage for the use of andrographolide in upper respiratory tract infections (URTIs) and other viral infectious diseases. The data were collected from the literature on absorption, distribution, biotransformation, and excretion of andrographolide, and information was also obtained from scientific databases about the use of A. paniculata. The finding of this review on pharmacokinetics indicates that andrographolide is slightly absorbed into the blood circulation and exhibits poor oral bioavailability, whereas its distribution process is unrestricted. In the termination phase, andrographolide preferentially undergoes biotransformation partly through phase I hydroxylation and phase II conjugation, and it is then eliminated via the renal excretion and hepatobiliary system. The key summary of the recommended dosage for andrographolide in uncomplicated URTI treatment is 30 mg/day for children and 60 mg/day for adults. The dose for adult patients with pharyngotonsillitis could be increased to 180 mg/day, but not exceed 360 mg/day. Co-treatment with A. paniculata in concert with the standard supportive care for influenza reduced the severity of symptoms, shortened treatment duration, and decreased the risk of developing post-influenza complications. The recommended starting dose for use in patients with mild COVID-19 is 180 mg/day of andrographolide, based on the dose used in patients experiencing a URTI with inflammation. This review is not only applicable for evaluating the appropriate doses of andrographolide for antiviral treatments but also encourages future research evaluating the effectiveness of these recommended dosages during the COVID-19 pandemic.

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Section: Metabolismsupporting

confidence: 89%

Section: Metabolismmentioning

confidence: 99%

A comprehensive review on disposition kinetics and dosage of oral administration of Andrographis paniculata, an alternative herbal medicine, in co-treatment of coronavirus disease

Songvut

Suriyo²,

Panomvana³

et al. 2022

Front. Pharmacol.

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“…A. paniculata , a medicinal plant typically used as an anti-inflammatory and antimicrobial agent, has been studied for its possible impact on the management of DM in humans ( Nugroho et al, 2012 ; Dai et al, 2019 ; Adiguna et al, 2021 ; Hossain et al, 2021 ). Andrographolide is a potential bioactive phytochemical in A. paniculata , which possesses antidiabetic properties ( Nugroho et al, 2012 ; Ji et al, 2016 ; Islam, 2017 ; Naik et al, 2017 ; Mehta et al, 2021 ; Syukri et al, 2021 ). Plasma andrographolide was detected in dogs orally treated with A. paniculata tablets, indicating that andrographolide can be absorbed via the GI tract ( Xu et al, 2015 ).…”

Section: Discussionmentioning

confidence: 99%

Antidiabetic effects of Andrographis paniculata supplementation on biochemical parameters, inflammatory responses, and oxidative stress in canine diabetes

Suemanotham

Phochantachinda²,

Chatchaisak³

et al. 2023

Front. Pharmacol.

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Introduction: Diabetes mellitus is a common endocrine disorder that causes hyperglycemia in dogs. Persistent hyperglycemia can induce inflammation and oxidative stress. This study aimed to investigate the effects of A. paniculata (Burm.f.) Nees (Acanthaceae) (A. paniculata) on blood glucose, inflammation, and oxidative stress in canine diabetes. A total of 41 client-owned dogs (23 diabetic and 18 clinically healthy) were included in this double-blind, placebo-controlled trial.Methods: The diabetic dogs were further divided into two treatments protocols: group 1 received A. paniculata extract capsules (50 mg/kg/day; n = 6) or received placebo for 90 days (n = 7); and group 2 received A. paniculata extract capsules (100 mg/kg/day; n = 6) or received a placebo for 180 days (n = 4). Blood and urine samples were collected every month. No significant differences in fasting blood glucose, fructosamine, interleukin-6, tumor necrosis factor-alpha, superoxide dismutase, and malondialdehyde levels were observed between the treatment and placebo groups (p > 0.05).Results and Discussion: The levels of alanine aminotransferase, alkaline phosphatase, blood urea nitrogen, and creatinine were stable in the treatment groups. The blood glucose levels and concentrations of inflammatory and oxidative stress markers in the client-owned diabetic dogs were not altered by A. paniculata supplementation. Furthermore, treatment with this extract did not have any adverse effects on the animals. Non-etheless, the effects of A. paniculata on canine diabetes must be appropriately evaluated using a proteomic approach and involving a wider variety of protein markers.

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“…Andrographis paniculata is a plant with high chemical diversity, containing diterpenoid lactones, such as the following: several andrographolides; flavonoids, mainly flavanones, flavones, and flavonols; terpenoids, phenolic acids, including ferulic, caffeic, vanillic, and chlorogenic acids; chalcones, xanthones, and volatile compounds [ 140 , 141 ]. Based on its rich chemical diversity, Andrographis paniculata has anti-inflammatory, analgesic, antipyretic, anti-oedema, antioxidant, antihyperglycemic, hepatoprotective, antibacterial, antiparasitic, antiviral, antitumoral, immunomodulatory, antihyperlipidemic, contraceptive, neuroprotective, and protective cardiovascular effects [ 140 , 141 , 142 ]. The anti-aging properties of Andrographis paniculata hydroethanolic extract 50% were reported using in vivo, ex vivo, and in vivo clinical studies with thirty-two healthy female volunteers [ 42 ].…”

Section: Promising Natural Compounds and Herbal Preparation For The D...mentioning

confidence: 99%

Recent Advances in Herbal-Derived Products with Skin Anti-Aging Properties and Cosmetic Applications

2022

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Although aesthetic benefits are a desirable effect of the treatment of skin aging, it is also important in controlling several skin diseases, mainly in aged people. The development of new dermocosmetics has rapidly increased due to consumers’ demand for non-invasive products with lower adverse effects than those currently available on the market. Natural compounds of plant origin and herbal-derived formulations have been popularized due to their various safe active products, which act through different mechanisms of action on several signaling pathways for skin aging. Based on this, the aim of the review was to identify the recent advances in herbal-derived product research, including herbal formulations and isolated compounds with skin anti-aging properties. The studies evaluated the biological effects of herbal-derived products in in vitro, ex vivo, and in vivo studies, highlighting the effects that were reported in clinical trials with available pharmacodynamics data that support their protective effects to treat, prevent, or control human skin aging. Thus, it was possible to identify that gallic and ferulic acids and herbal formulations containing Thymus vulgaris, Panax ginseng, Triticum aestivum, or Andrographis paniculata are the most promising natural products for the development of new dermocosmetics with skin anti-aging properties.

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Pharmacological activities and molecular mechanisms of pure and crude extract of Andrographis paniculata: An update

Cited by 26 publications

References 116 publications

A comprehensive review on disposition kinetics and dosage of oral administration of Andrographis paniculata, an alternative herbal medicine, in co-treatment of coronavirus disease

A comprehensive review on disposition kinetics and dosage of oral administration of Andrographis paniculata, an alternative herbal medicine, in co-treatment of coronavirus disease

Antidiabetic effects of Andrographis paniculata supplementation on biochemical parameters, inflammatory responses, and oxidative stress in canine diabetes

Recent Advances in Herbal-Derived Products with Skin Anti-Aging Properties and Cosmetic Applications

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