Pharmacological Activities for Morus alba L., Focusing on the Immunostimulatory Property from the Fruit Aqueous Extract

Chang, BoYoon; Koo, Bong‐Seong; Kim, Sung-Yeon

doi:10.3390/foods10081966

Cited by 20 publications

(8 citation statements)

References 148 publications

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“…According to Bencao Gangmu (A.D.1578–1593) and Donguibogam (A.D. 1613), Morus alba L. fruit has been a traditional plant with many applications including the ability to alleviate hyperglycemia and hypertension, enhance liver and kidney function, remedy fever, strengthen the joints and moisten dryness and other disorders for thousands of years in East Asia [ 11 , 12 ]. In the Chinese pharmacopoeia version of 2020, Morus alba L. fruit is used for the treatment of liver and kidney deficiency, dizziness and tinnitus, palpitation and insomnia, premature graying hair, diabetes, constipation and intestinal dryness [ 13 ].…”

Section: Introductionmentioning

confidence: 99%

Polyphenols and Polysaccharides from Morus alba L. Fruit Attenuate High-Fat Diet-Induced Metabolic Syndrome Modifying the Gut Microbiota and Metabolite Profile

Wan

Lei

et al. 2022

Foods

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Morus alba L. fruit, a medicinal and edible fruit in East Asia, showed potential health-promoting effects against metabolic syndrome (MetS). However, both the protective effects and mechanism of different fractions extracted from Morus alba L. fruit against MetS remain unclear. Additionally, the gut microbiota and its metabolites are regarded as key factors in the development of MetS. This study aimed to investigate the potential role of polyphenols and polysaccharides derived from Morus alba L. fruit against MetS in high-fat diet (HFD)-fed mice, individually and in combination, focusing on remodeling effects on gut microbiota and metabolite profiles. In the study, polyphenols and polysaccharides derived from Morus alba L. fruit improved the traditional pharmacodynamic parameters of MetS, including reductions in body weight (BW) and fat accumulation, improvement in insulin resistance, regulation of dyslipidemia, prevention of pathological changes in liver, kidney and proximal colon tissue, and suppressive actions against oxidative stress. In particular, the group treated with polyphenols and polysaccharides in combination showed better efficacy. The relative abundance of beneficial bacterial genera Muribaculum and Lachnospiraceae_NK4A136_group were increased to various degrees, while opportunistic pathogens such as Prevotella_2, Bacteroides, Faecalibacterium and Fusobacterium were markedly decreased after treatments. Moreover, fecal metabolite profiles revealed 23 differential metabolites related to treatments with polyphenols and polysaccharides derived from Morus alba L. fruit, individually and in combination. Altogether, these results demonstrated that polyphenols and polysaccharides derived from Morus alba L. fruit attenuated MetS in HFD-fed mice, and improved the gut microbiota composition and fecal metabolite profiles.

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Section: Introductionmentioning

confidence: 99%

Polyphenols and Polysaccharides from Morus alba L. Fruit Attenuate High-Fat Diet-Induced Metabolic Syndrome Modifying the Gut Microbiota and Metabolite Profile

Wan

Lei

et al. 2022

Foods

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“…The anticarcinogenic mechanisms of mulberry phenols demonstrated in several cell cancer lines or in animal tumor models include antioxidant activity, antiproliferation, the induction of apoptosis and antiangiogenic activity [2,[128][129][130].…”

Section: Anticancer Activitymentioning

confidence: 99%

“…Recently, it was reported that M. alba fruits induce the phenotypic maturation of dendritic cells due to the polysaccharides in the composition, and can thus be used as an adjunct in dendritic-cell cancer immunotherapy [128].…”

Section: Immunomodulatory Effectmentioning

confidence: 99%

Phytochemical Composition of Different Botanical Parts of Morus Species, Health Benefits and Application in Food Industry

Memete

Timar

Vuşcan

et al. 2022

Plants

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In recent years, mulberry has acquired a special importance due to its phytochemical composition and its beneficial effects on human health, including antioxidant, anticancer, antidiabetic and immunomodulatory effects. Botanical parts of Morus sp. (fruits, leaves, twigs, roots) are considered a rich source of secondary metabolites. The aim of our study was to highlight the phytochemical profile of each of the botanical parts of Morus tree, their health benefits and applications in food industry with an updated review of literature. Black and white mulberries are characterized in terms of predominant phenolic compounds in correlation with their medical applications. In addition to anthocyanins (mainly cyanidin-3-O-glucoside), black mulberry fruits also contain flavonols and phenolic acids. The leaves are a rich source of flavonols, including quercetin and kaempferol in the glycosylated forms and chlorogenic acid as predominant phenolic acids. Mulberry bark roots and twigs are a source of prenylated flavonoids, predominantly morusin. In this context, the exploitation of mulberry in food industry is reviewed in this paper, in terms of developing novel, functional food with multiple health-promoting effects.

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“…The fruit of Morus alba (MA) L. (mulberry), from the family Moraceae, has been consumed as a food and dietary supplement for a long time and is rich in vitamin C, anthocyanins, flavonoids, and alkaloids. MA fruit and fruit extracts have shown antioxidant, antidiabetic, antiatherosclerotic, antiobesity, anticholesterol, and antibacterial activities, as well as immune enhancement, neuroprotective, and hepatoprotective properties (Chan et al, 2016;Chang et al, 2021;Hansawasdi and Kawabata, 2006;Zafar et al, 2013;Zhang et al, 2018). MA extracts are considered safe to use without severe side effects.…”

Section: Introductionmentioning

confidence: 99%

Impact of Morus alba L. on the expression of drug-metabolizing enzymes and transporters in Caco-2 cells

Chatuphonprasert¹,

Wattanathorn²,

Tukum-mee³

et al. 2022

j app pharm sci

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Morus alba (MA) L. (mulberry) fruit has been consumed for a long time as a food and a source of vitamin C, anthocyanins, flavonoids, and alkaloids. The effects of MA fruit extract on drug-metabolizing genes and drug transporters were investigated in human colorectal adenocarcinoma cells. Cells treated with MA or its major bioactive constituents, rutin, and cyanidin-3-O-glucoside (C3G), were assessed for cell viability, production of reactive oxygen species (ROS), and alanine aminotransferase (ALT) and aspartate transaminase (AST) levels. The mRNA expression of target metabolic genes was determined using real-time polymerase chain reaction. Cell viability remained higher than 80%, and ROS levels were unchanged by all treatments. MA, C3G, and rutin did not alter the ALT and AST levels or expression of CYP2D6 and sulfotransferase 1A1 (SULT1A1). However, MA, C3G, and rutin down-regulated the expression of CYP2C19, CYP3A4, uridine diphosphate-glucuronosyltransferase 1A6 (UGT1A6), N-acetyltransferase 1, and organic anion transporting polypeptide 1B1 (OATP1B1), and MA elevated the expression of CYP1A2. In addition, MA induced CYP1A2 and CYP2C19 expression in combination with aspirin, caffeine, and simvastatin and upregulated expression of UGT1A6 and SULT1A1 in combination with paracetamol. Therefore, consumption of MA fruit or its supplements poses a risk for drug interactions via its modulation of cytochrome P450 and conjugation enzyme-associated metabolism and OATP1B1-mediated drug transport.

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Pharmacological Activities for Morus alba L., Focusing on the Immunostimulatory Property from the Fruit Aqueous Extract

Cited by 20 publications

References 148 publications

Polyphenols and Polysaccharides from Morus alba L. Fruit Attenuate High-Fat Diet-Induced Metabolic Syndrome Modifying the Gut Microbiota and Metabolite Profile

Polyphenols and Polysaccharides from Morus alba L. Fruit Attenuate High-Fat Diet-Induced Metabolic Syndrome Modifying the Gut Microbiota and Metabolite Profile

Phytochemical Composition of Different Botanical Parts of Morus Species, Health Benefits and Application in Food Industry

Impact of Morus alba L. on the expression of drug-metabolizing enzymes and transporters in Caco-2 cells

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