Pharmacological and haematological results of rat skin burn injury treatment with Cu(II)2(3,5-diisopropylsalicylate)4

Abstract

This research was performed to determine whether or not treatment of burn-injured rats with Cu(II)2(3,5-diisopropylsalicylate)4(Cu(II)2(3,5-DIPS)4) facilitated recovery from burn-injury. Four groups of adult male rats received a standard skin burn 1 h before an initial subcutaneous treatment which was continued daily for three days with either 0, 5, 10 or 20micromol Cu(II)2(3,5-DIPS)4/kg body mass. A fifth group was given no treatment. A sixth group served as a non-burn-injured non-treated normal control group. At 3 h and on days 1, 2, 3, 7 and 14 post-burn-injury blood samples were obtained from rats in all groups for the determination of leukocyte, platelet and erythrocyte counts, clotting times, hemoglobin and hematocrit values. Total protein and middle mass peptides in plasma, as well as plasma lipid and erythrocyte membrane peroxidation products were determined on days 7 and 14. Burn wound healing and body mass were determined daily from day 0 to 6 with a notation of crust rejection by day 14. Treatment with Cu(II)2(3,5-DIPS)4 produced effects consistent with a facilitation of Cu-dependent immune-mediated physiological inflammatory responses to burn injury. It is concluded that treatment of burn injury with Cu(II)2(3,5-DIPS)4 supports Cu-dependent physiological responses involved in overcoming burn injury, which may have been further optimized by continued treatment beyond day 2, the last day of treatment.

Absorption and release of zinc and copper ions by chitosan fibers

“…During the healing of burn wound, Zn(II) and Cu(II) concentrations exceeded plasma concentrations, suggesting that inflammatory wound exudate was a primary route for Zn(II) and Cu(II) loss, and at the same time, indicating the need to supplement Zn(II) and Cu(II) ions during the healing process for burn wounds. Malakyan et al9 determined the efficacy of a Cu(II) complex in facilitating recovery from burn injury. They found that treatment with Cu(II) complex produced effects consistent with a facilitation of Cu‐dependent immune‐mediated physiological inflammatory response to burn injury.…”

Copper nanoparticles loaded alginate‐impregnated cotton fabric with antibacterial properties

“…Since burn injuries are associated with reduced bone formation and resorption in both adult and children,6 the copper ions may be expected to play a dual role in healing of burn injuries,7 namely, preventing the wound from infection and helping in formation of bone matrix. Malakyan et al,8 determined the efficacy of Cu(II) complex in facilitating recovery from burn injury. They found that treatment with Cu(II) complex produced effects, consistent with a facilitation of Cu‐dependent immune‐mediated physiological inflammatory response to burn injury.…”

Copper (II) ions and copper nanoparticles‐loaded chemically modified cotton cellulose fibers with fair antibacterial properties

“…Adequate status of this mineral may be particularly difficult to monitor in children with burns because of the rapid growth and hormonal changes. Malakyan et al28 determined the efficacy of Cu(II) complex in facilitating recovery from burn injury. They found that treatment with Cu(II) complex produced effects consistent with a facilitation of Cu‐dependent immune‐mediated physiological inflammatory response to burn injury.…”