Pharmacological and Toxicological Evaluation of Methotrexate and Naproxen in Treating Hepatocellular Carcinoma in Wistar Rat

Abstract

The liver is one of the heaviest organs in the body (1.2–1.5 kg) and serve the most important function of maintaining the body’s internal environment. The anatomical location of the liver is key to fulfill this role, as almost all absorption of unknown material into the body takes place in the gut and the portal blood draining the gut flows to the liver, which later controls the release of absorbed nutrients into the systemic circulation. In adding together to its function in metabolizing nutrients, the liver is capable to store and liberate a variety of substrates, vitamins and plays an essential role in drug and bilirubin metabolism. Liver cancer is most of the deadliest disease in the whole world which has been increasing day by day. The present study was aimed to investigate the activity of Methotrexate (MTX) and Naproxen (Np) to reduce the risk of liver cancer induced by Diethylnitrosamine (DENA) on rats. After examination, it was observed that pharmacological assessment of MTX and Np shows positive reactions toward treating DENA-induced Hepatocellular Carcinoma in animals.