Pharmacological and Toxicological Properties of Leaf Extracts of Kingelia africana (Bignoniaceae)

Hassan, Sanusi Wara; Abubakar, MG; ., R.A. Umar; Yakubu, Abdulmalik; Maishanu, H. M.; Ayeni, Gabriel Omoniyi

doi:10.3923/jpt.2011.124.132

Cited by 21 publications

(21 citation statements)

References 2 publications

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“…Collagen is a major protein of the extracellular matrix and is the component that ultimately contributes to wound strength. [14] The healing process depends, to a large extent, on the regulated biosynthesis and deposition of new collagens and their subsequent maturation. [23] Assessment of collagen content in granulation tissues of control and experimental wounds clearly suggests that H. rosa sinensis enhances collagen synthesis and deposition.…”

Section: Discussionmentioning

confidence: 99%

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Evaluation of the wound-healing activity of Hibiscus rosa sinensis L (Malvaceae) in Wistar albino rats

Bhaskar

Nithya²

2012

Indian J Pharmacol

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Objective:To investigate the wound-healing potency of the ethanolic extract of the flowers of Hibiscus rosa sinensis.Materials and Methods:The wound-healing activity of H. rosa sinensis (5 and 10% w/w) on Wistar albino rats was studied using three different models viz., excision, incision and dead space wound. The parameters studied were breaking strength in incision model, granulation tissue dry weight, breaking strength and collagen content in dead space wound model, percentage of wound contraction and period of epithelization in excision wound model. The granulation tissue formed on days 4, 8, 12, and 16 (post-wound) was used to estimate total collagen, hexosamine, protein, DNA and uronic acid. Data were analyzed by Analysis of Variance (ANOVA) test. P<0.05 was considered statistically significant.Results:The extract increased cellular proliferation and collagen synthesis at the wound site, as evidenced by increase in DNA, total protein and total collagen content of granulation tissues. The extract-treated wounds were found to heal much faster as indicated by improved rates of epithelialization and wound contraction. The extract of H. rosa sinensis significantly (P<0.001) increased the wound-breaking strength in the incision wound model compared to controls. The extract-treated wounds were found to epithelialize faster, and the rate of wound contraction was significantly (P<0.001) increased as compared to control wounds. Wet and dry granulation tissue weights in a dead space wound model increased significantly (P<0.001). There was a significant increase in wound closure rate, tensile strength, dry granuloma weight, wet granuloma weight and decrease in epithelization period in H. rosa sinensis-treated group as compared to control and standard drug-treated groups.Conclusion:The ethanolic extract of H. rosa sinensis had greater wound-healing activity than the nitrofurazone ointment.

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Section: Discussionmentioning

confidence: 99%

“…Wet weight was recorded and tensile strength determined. [14] The granuloma was dried in an oven at 60°C and the dry weight noted. The tensile strength was measured using a tensiometer.…”

Section: Ointment Formulationmentioning

confidence: 99%

Evaluation of the wound-healing activity of Hibiscus rosa sinensis L (Malvaceae) in Wistar albino rats

Bhaskar

Nithya²

2012

Indian J Pharmacol

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“…p value was calculated by Student t test (p ≤ 0.05). Error bars with superscript "a" represents that there was no statistical difference in levels among various groups E. crassipes on GC-MS analysis showed the presence of many secondary metabolites which have capabilities like antibacterial and anti-viral properties, including protection against many diseases: anti-tumor, anti-cancer, neuroprotective, allergenic, oxidative stress inhibitor, NO-inhibitor, and cardio-protective (Hassan et al, 2011;Somasagara et al, 2012;Valenzuela, Imarai, Torres, & Modak, 2013).…”

Section: Discussionmentioning

confidence: 99%

Water hyacinth (Eichhornia crassipes) leaves enhances disease resistance in Channa punctata from Vibrio harveyi infection

Verma

Prakash

Kumar

et al. 2021

JoBAZ

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Background Channa punctata, Indian spotted snakehead, has a great economic value in south and south-east Asia being an important protein source for humans. Fish cultures are affected due to various bacterial and viral infections. Vibrio harveyi is a fish pathogenic bacteria which causes several outbreaks throughout the world and leads to huge mortalities. In this study, leaves of Eichhornia crassipes (water hyacinth) were used to investigate its immunostimulatory potential in Channa punctata. Results The immunostimulatory effects of water hyacinth leaves were studied in fish fed with 2.5% and 5% supplementary feed (experimental groups) in comparison to normal feed (control groups). Gas chromatography mass spectrometry (GC-MS) analysis of E. crassipes methanol extract showed presence of various components which have immunostimulatory, antioxidant, antibacterial, and anti-inflammatory activities. The antibacterial activity, antioxidant potential, and presence of phenol and flavonoids in methanol and ethanol extracts supported its use in fish feed. The healthy acclimatized fish were challenged with V. harveyi weekly. Liver function tests, alkaline phosphatase levels, and immunoglobulin content in the experimental groups were improved with respect to those in the positive control group. The spleen and head kidney were obtained at the final day of experiment, and macrophages were isolated; higher percentage of phagocytosis and phagocytic index indicated enhanced cell-mediated immune response in fish due to supplemented feed. Conclusion Plant-infused feed with leaves of E. crassipes can be recommended as a regular feed supplement to enhance fish immunity and disease resistance against the V. harveyi infection.

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“…In contrast to that, the EECN extract ointment as already mentioned reveals rich phenolic and flavonoids presence that might have multiple mechanism in favor of wound healing. Collagen is a key extracellular protein in the granulation tissue of healing wound and is the vital component that ultimately plays an important role in wound strength and integrity of tissue matrix [ 26 ]. Wound healing process largely depends on the controlled synthesis and deposition of new collagens and their consequent maturation [ 27 ].…”

Section: Discussionmentioning

confidence: 99%

Pharmacological Investigation of the Wound Healing Activity of Cestrum nocturnum (L.) Ointment in Wistar Albino Rats

Nagar¹,

Srivastava²,

Srivastava³

et al. 2016

Journal of Pharmaceutics

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Objectives. The present study was aimed at investigating the wound healing effect of ethanolic extract of Cestrum nocturnum (L.) leaves (EECN) using excision and incision wound model. Methods. Wistar albino rats were divided into five groups each consisting of six animals; group I (left untreated) considered as control, group II (ointment base treated) considered as negative control, group III treated with 5% (w/w) povidone iodine ointment (Intadine USP), which served as standard, group IV treated with EECN 2% (w/w) ointment, and group V treated with EECN 5% (w/w) ointment were considered as test groups. All the treatments were given once daily. The wound healing effect was assessed by percentage wound contraction, epithelialization period, and histoarchitecture studies in excision wound model while breaking strength and hydroxyproline content in the incision wound model. Result. Different concentration of EECN (2% and 5% w/w) ointment promoted the wound healing activity significantly in both the models studied. The high rate of wound contraction (P < 0.001), decrease in the period for epithelialization (P < 0.01), high skin breaking strength (P < 0.001), and elevated hydroxyproline content were observed in animal treated with EECN ointments when compared to the control and negative control group of animals. Histopathological studies of the EECN ointments treated groups also revealed the effectiveness in improved wound healing. Conclusions. Ethanolic extract of Cestrum nocturnum (EECN) leaves possesses a concentration dependent wound healing effect.

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Pharmacological and Toxicological Properties of Leaf Extracts of Kingelia africana (Bignoniaceae)

Cited by 21 publications

References 2 publications

Evaluation of the wound-healing activity of Hibiscus rosa sinensis L (Malvaceae) in Wistar albino rats

Evaluation of the wound-healing activity of Hibiscus rosa sinensis L (Malvaceae) in Wistar albino rats

Water hyacinth (Eichhornia crassipes) leaves enhances disease resistance in Channa punctata from Vibrio harveyi infection

Pharmacological Investigation of the Wound Healing Activity of Cestrum nocturnum (L.) Ointment in Wistar Albino Rats

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