2016
DOI: 10.1155/2016/9249040
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Pharmacological Investigation of the Wound Healing Activity of Cestrum nocturnum (L.) Ointment in Wistar Albino Rats

Abstract: Objectives. The present study was aimed at investigating the wound healing effect of ethanolic extract of Cestrum nocturnum (L.) leaves (EECN) using excision and incision wound model. Methods. Wistar albino rats were divided into five groups each consisting of six animals; group I (left untreated) considered as control, group II (ointment base treated) considered as negative control, group III treated with 5% (w/w) povidone iodine ointment (Intadine USP), which served as standard, group IV treated with EECN 2%… Show more

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Cited by 83 publications
(69 citation statements)
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“…A. maurorum extract and the alginate aqueous solution were used for the MTT assay. Although some of the previous studies directly used the herb extracts (Nagar et al, ) or polymers (Roh et al, ) for in vivo assays, in this research, the nontoxic concentration of each material was determined first. Then, the substance was used for in vivo analyses, in its calculated nontoxic dose.…”
Section: Discussionmentioning
confidence: 99%
“…A. maurorum extract and the alginate aqueous solution were used for the MTT assay. Although some of the previous studies directly used the herb extracts (Nagar et al, ) or polymers (Roh et al, ) for in vivo assays, in this research, the nontoxic concentration of each material was determined first. Then, the substance was used for in vivo analyses, in its calculated nontoxic dose.…”
Section: Discussionmentioning
confidence: 99%
“…This could be due to in lammatory mediators released from mast cells, causing in lammation and healing of burns. In lammatory mediators (TNF-α, IL-1), platelet-derived growth factor (PDGF) growth factors (TGF-β1), and proteases are released during tissue injury (Nagar et al, 2016).…”
Section: Simple Metal Plate Contact Burn Model Of Wistar Ratmentioning
confidence: 99%
“…[24][25][26] The hairs on the skin of animals were removed and disinfected using ethanol. 27,28 Then area of wound to be produced was marked with a circular stainless-steel stencil on the dorsal thoracic region on the back of the rats with methylene blue. Using toothed forceps and pointed scis-sors, a circular fragment (300mm 2 in area) in length and 0.2 cm depth of total thick skin was excised.…”
Section: Stability Studymentioning
confidence: 99%