Pharmacological Applications of Quercetin and its Derivatives: A Short Review

Abstract

Quercetin (3,3ʹ,4ʹ,5,7-pentahydroxyl- flavone) is a flavonol, and it belongs to a class of plant secondary metabolites known as flavonoids. It is present in man's daily diet and is known for biological activities such as antioxidant, antiviral, anticancer, antimicrobial, anti-inflammatory and many more. Quercetin has been reported for its antioxidant and antiviral applications, hence, it is not only used as such but also its various derivatized forms have potentials for development into drugs for the treatment of diseases caused by oxidative stress and lethal viruses.

Effects of methanol leaf extracts of <i>Loranthus micranthus</i> Linn from three host plants on some biochemical indices of diabetic rats

“…They have been shown to exhibit antidiabetic activity [6,7]. They also possess both antidyslipidemic and anti-anemic properties [6].…”

“…The level of phytochemicals in the leaf extracts ensured protective roles against oxidative stress associated with hyperglycemia. Flavonoids such as quercetin, boswellic, rutin and ellagic acid have been shown to possess antidiabetic activity [7]. The observed variations in the biological effects of the extracts could be due to variations in the phytochemical constituents [7,8] which in turn might be due to differences in the phytoconstituents of the host plants [18].…”

“…From our results, it could therefore be suggested that the L. micranthus extracts possess similar mechanism of action to that of glibenclamide. The antidiabetic effect of the extracts suggests that they possess antioxidant properties that led to the inhibition in lipid peroxidation in the animals [7,8]. The reduction in both cholesterol and triglycerides concentrations could be beneficial in preventing diabetic complications, improving lipid metabolism and preventing artherosclerotic plaque [5,7].…”

Basic Studies on Chemopreventive Properties of Quercetin and Curcumin and Other Plant-origin Compounds in Ovarian Cancer Cells – A Mini-review

“…One of the most abundant flavonol, identified in various types of vegetable [19][20][21], caper fruits [22], fruits [23], herbs (dill), some types of tea [24] and wine [25], being of the most extensively studied in this field is the quercetin [11,[26][27][28]. Numerous studies have demonstrated that another plant-origin constituent-curcumin (a yellow substance belonging to the polyphenols superfamily; active component of turmeric, a common Indian spice, derived i.e.…”

Isolation and Characterization of Quercetin From Amaranthaceae Family Plants

“…Quercetin does have ethnopharmacology property as an anticancer, antioxidant and neuroprotective. Phase-I clinical trials reported inhibition on tyrosine kinase by Quercetin which proposes it's use in tumours 13 .…”