Pharmacological characterisation of the dopamine-sensitive adenylate cyclase in cockroach brain: Evidence for a distinct dopamine receptor

Orr, Gregory L.; Gole, J.W.D.; Notman, H.J.; Downer, Roger

doi:10.1016/0024-3205(87)90463-2

Cited by 33 publications

(8 citation statements)

References 17 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Because of the high degree of sequence similarity for the DA receptors between Manduca and Bombyx, SCH23390 is likely an effective Dop1-and INDR-type receptor antagonist in Manduca. However, it should be noted that SCH23390 has not been directly tested on serotonin or octopamine receptors in moths, although SCH23390 is ϳ25 times more effective at blocking the effects of DA compared with octopamine in crude membrane preparations from cockroach brain (Orr et al 1987). All solutions included 0.1 M DMSO.…”

Section: Methodsmentioning

confidence: 98%

Olfactory modulation by dopamine in the context of aversive learning

Dacks

Riffell

Martin

et al. 2012

Journal of Neurophysiology

View full text Add to dashboard Cite

The need to detect and process sensory cues varies in different behavioral contexts. Plasticity in sensory coding can be achieved by the context-specific release of neuromodulators in restricted brain areas. The context of aversion triggers the release of dopamine in the insect brain, yet the effects of dopamine on sensory coding are unknown. In this study, we characterize the morphology of dopaminergic neurons that innervate each of the antennal lobes (ALs; the first synaptic neuropils of the olfactory system) of the moth Manduca sexta and demonstrate with electrophysiology that dopamine enhances odor-evoked responses of the majority of AL neurons while reducing the responses of a small minority. Because dopamine release in higher brain areas mediates aversive learning we developed a naturalistic, ecologically inspired aversive learning paradigm in which an innately appetitive host plant floral odor is paired with a mimic of the aversive nectar of herbivorized host plants. This pairing resulted in a decrease in feeding behavior that was blocked when dopamine receptor antagonists were injected directly into the ALs. These results suggest that a transient dopaminergic enhancement of sensory output from the AL contributes to the formation of aversive memories. We propose a model of olfactory modulation in which specific contexts trigger the release of different neuromodulators in the AL to increase olfactory output to downstream areas of processing.

show abstract

Section: Methodsmentioning

confidence: 98%

Olfactory modulation by dopamine in the context of aversive learning

Dacks

Riffell

Martin

et al. 2012

Journal of Neurophysiology

View full text Add to dashboard Cite

show abstract

“…Other effects of dopamine in insect brains are mediated by receptors with pharmacologies distinct from those of vertebrate dopamine receptors (Orr et al, 1987;Davis and Pitman, 1991;Kokay and Mercer, 1996). The existence of two dopamine D1-like receptor subtypes in Drosophila has been demonstrated by gene cloning (Gotzes et al, 1994;Sugamori et al, 1995;Feng et al, 1996).…”

Section: Abstract: Cloned Dopamine Receptor; Drosophila Melanogastermentioning

confidence: 99%

Agonist-Specific Coupling of a ClonedDrosophila melanogasterD1-Like Dopamine Receptor to Multiple Second Messenger Pathways by Synthetic Agonists

et al. 1997

View full text Add to dashboard Cite

The mechanism of coupling of a cloned Drosophila D1-like dopamine receptor, DopR99B, to multiple second messenger systems when expressed in Xenopus oocytes is described. The receptor is coupled directly to the generation of a rapid, transient intracellular Ca 2ϩ signal, monitored as changes in inward current mediated by the oocyte endogenous Ca 2ϩ -activated chloride channel, by a pertussis toxin-insensitive G-proteincoupled pathway. The more prolonged receptor-mediated changes in adenylyl cyclase activity are generated by an independent G-protein-coupled pathway that is pertussis toxinsensitive but calcium-independent, and G ␤␥ -subunits appear to be involved in the transduction of this response. This is the first evidence for the direct coupling of a cloned D1-like dopamine receptor both to the activation of adenylyl cyclase and to the initiation of an intracellular Ca 2ϩ signal. The pharmacological profile of both second messenger effects is identical for a range of naturally occurring catecholamine ligands (dopamine Ͼ norepinephrine Ͼ epinephrine) and for the blockade of dopamine responses by a range of synthetic antagonists. However, the pharmacological profiles of the two second messenger responses differ for a range of synthetic agonists. Thus, the receptor exhibits agonist-specific coupling to second messenger systems for synthetic agonists. This feature could provide a useful tool in the genetic analysis of the roles of the multiple second messenger pathways activated by this receptor, given the likely involvement of dopamine in the processes of learning and memory in the insect nervous system.

show abstract

“…Afterwards, there was a spate of activity leading to the uncovering of multiple D 1 -like transcripts in different organisms. Thus, current evidence indicates that D 1 -like receptors are expressed in diverse species, including the fruit fly (Gotzes et al, 1994; Sugamori et al, 1995; Han et al, 1996; Reale et al, 1997; Schetz et al, 2003; Kehren and Baumann, 2005), cockroach (Orr et al, 1987; Evans et al, 1991; Evans and Green, 1991), locust (Homberg, 2002; Keating and Orchard, 2004), spider (Schmidt et al, 1981; Sauer et al, 1994), eel (Cardinaud et al, 1997), earthworm (Gardner and Cashin, 1975; Shpakov et al, 2008), flatworm (Venturini et al, 1989), goldfish (Mora-Ferrer et al, 1999), tree frog, (Agui et al, 1988; Schutte, 1991; Liu and Lasater, 1994; Behrens and Wagner, 1995) lizard (Clark et al, 2000), chicken (Agui et al, 1988; Demchyshyn et al, 1995; Schnabel et al, 1997; Sun and Reiner, 2000; Soares et al, 2000; Kubrusly et al, 2007), rodent (Grilli et al, 1988; Nisoli et al, 1988; Tiberi et al, 1991; Bryson et al, 1992; Mannoury la Cour et al, 2007), monkey (Besson et al, 1988; Sedvall et al, 1991; Choi et al, 1995; Bergson et al, 1995a; Bergson et al, 1995b) and humans (De Keyser et al, 1988a; De Keyser et al, 1988b; Dearry et al, 1990; Sunahara et al, 1990; Sidhu and Fishman, 1990; Grandy et al, 1990; Weinshank et al, 1991; Ferreira-de-Almeida et al, 1993). Among these species, multiple structurally divergent subtypes of D 1 -like receptors have been detected, including at least 3 transcripts in Xenopus (D 1A , D 1B and D 1C ), 4 in the chicken (D 1A , D 1B , D 1C and D 1D ), 2 in the mouse or rat (D 1A and D 1B ), 2 in the monkey, and 2 in humans (D 1 and D 5 ).…”

Section: Introductionmentioning

confidence: 99%

Pharmacology of signaling induced by dopamine D1-like receptor activation

Undieh

2010

Pharmacology & Therapeutics

110

View full text Add to dashboard Cite

Dopamine D1-like receptors consisting of D1 and D5 subtypes are intimately implicated in dopaminergic regulation of fundamental neurophysiologic processes such as mood, motivation, cognitive function, and motor activity. Upon stimulation, D1-like receptors initiate signal transduction cascades that are mediated through adenylyl cyclase or phosphoinositide metabolism, with subsequent enhancement of multiple downstream kinase cascades. The latter actions propagate and further amplify the receptor signals, thus predisposing D1-like receptors to multifaceted interactions with various other mediators and receptor systems. The adenylyl cyclase response to dopamine or selective D1-like receptor agonists is reliably associated with the D1 subtype, while emerging evidence indicates that the phosphoinositide responses in native brain tissues may be preferentially mediated through stimulation of the D5 receptor. Besides classic coupling of each receptor subtype to specific G proteins, additional biophysical models are advanced in attempts to account for differential subcellular distribution, heteromolecular oligomerization, and activity-dependent selectivity of the receptors. It is expected that significant advances in understanding of dopamine neurobiology will emerge from current and anticipated studies directed at uncovering the molecular mechanisms of D5 coupling to phosphoinositide signaling, the structural features that might enhance pharmacological selectivity for D5 versus D1 subtypes, the mechanism by which dopamine may modulate phosphoinositide synthesis, the contributions of the various responsive signal mediators to D1 or D5 interactions with D2-like receptors, and the spectrum of dopaminergic functions that may be attributed to each receptor subtype and signaling pathway.

show abstract

Pharmacological characterisation of the dopamine-sensitive adenylate cyclase in cockroach brain: Evidence for a distinct dopamine receptor

Cited by 33 publications

References 17 publications

Olfactory modulation by dopamine in the context of aversive learning

Olfactory modulation by dopamine in the context of aversive learning

Agonist-Specific Coupling of a ClonedDrosophila melanogasterD1-Like Dopamine Receptor to Multiple Second Messenger Pathways by Synthetic Agonists

Pharmacology of signaling induced by dopamine D1-like receptor activation

Contact Info

Product

Resources

About