Pharmacological correlation between the formalin test and the neuropathic pain behavior in different species with chronic constriction injury

Vissers, Kris; Geenen, Frank; Biermans, R.; Meert, Theo

doi:10.1016/j.pbb.2006.06.011

Cited by 41 publications

(29 citation statements)

References 51 publications

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“…In this study, treatment with amitriptyline produced a significant antiallodynia effect, which is in accordance with other reports (Bomholt et al 2005;Vissers et al 2006). However, to the best of our knowledge, this is the first time that the anti-immobility effect of amitriptyline in a CCI neuropathic pain-like state was demonstrated.…”

Section: Discussionsupporting

confidence: 93%

Depression-like behavior and mechanical allodynia are reduced by bis selenide treatment in mice with chronic constriction injury: a comparison with fluoxetine, amitriptyline, and bupropion

2010

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These data demonstrate an important dissociation between the antiallodynic and antidepressant effects in mice when tested in a model of neuropathic pain. Depressive behavior in CCI mice was reversed by bis selenide and amitriptyline but not by the conventional antidepressants fluoxetine and buproprion. Bis selenide was more potent than the other drugs tested for antidepressant-like and antiallodynic effects in mice.

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Section: Discussionsupporting

confidence: 93%

Depression-like behavior and mechanical allodynia are reduced by bis selenide treatment in mice with chronic constriction injury: a comparison with fluoxetine, amitriptyline, and bupropion

2010

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“…The formalin test is one such method whereby rats are subcutaneously injected in the hind paw with a small volume of formalin which acts as an irritant. The test was originally exploited for assessing pain and analgesia using cats or rats (Dubuisson and Dennis, 1977), and has been used in various rat species (Barr et al, 2005;Lariviere et al, 2006;Vissers et al, 2006) as well as various animal species including mice (Cendan et al, 2005;Hacimuftuoglu et al, 2006;Rosland et al, 1990), rabbits (Carli et al, 1981), monkeys (Alreja et al, 1984) and guinea-pigs (Takahashi et al, fatigue which may result in high error rate. The second problem is the difficulty of quantification due to the elaborate nature of behavior.…”

Section: Introductionmentioning

confidence: 99%

A novel automated method for measuring the effect of analgesics on formalin-evoked licking behavior in rats

Sakiyama

Sujaku

Furuta

2008

Journal of Neuroscience Methods

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“…It has been reported 27) that the second phase of formalin test is comparable to cold allodynia in CCI model of neuropathic pain. Thus, the potent analgesic effects of obtusifolin and gluco-obtusifolin in the second phase of formalin test prompted us to test whether these molecules produce analgesic effects in models of neuropathic pain.…”

Section: Discussionmentioning

confidence: 95%

Anti-allodynic Effects of Obtusifolin and Gluco-Obtusifolin against Inflammatory and Neuropathic Pain

Wei

et al. 2014

Biological & Pharmaceutical Bulletin

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Inflammatory pain and neuropathic pain are major health issues that represent considerable social and economic burden worldwide. In this study we investigated the potential of obtusifolin and gluco-obtusifolin, two anthraquinones found in the seeds of the widely used traditional Chinese medical botanical Cassia obtusifolia, to reduce neuropathic and inflammatory pain. The potential analgesic effects of obtusifolin and gluco-obtusifolin were evaluated by mice formalin test and complete Freund's adjuvant (CFA)-induced nociceptive behaviors in rats. Chronic constriction injury (CCI), L5 spinal nerve ligation (L5 SNL), diabetes, and chemotherapeutics inducing allodynia were used to test whether repeated treatment with obtusifolin and gluco-obtusifolin ameliorated neuropathic pain. Finally, we explored whether obtusifolin and gluco-obtusifolin altered the degree of neuroinflammation in rat spinal cord after CFA administration and CCI induction. Obtusifolin and gluco-obtusifolin (0.25, 0.5, 1, and 2 mg/kg) reduced licking/biting time in dose-dependent manner in phase 2 of formalin-induced behavior in mice. Furthermore, repeated administration of obtusifolin and gluco-obtusifolin (0.25, 0.5, 1, and 2 mg/kg) reversed mechanical allodynia induced by CFA, CCI, L5 SNL, diabetes, and oxaliplatin in a dose-dependent manner in rats. Levels of activated nuclear factor-kappa B (NF-κB) and proinflammatory cytokines (interleukin (IL)-1β, IL-6, tumor necrosis factor α (TNF-α)) in lumbar spinal cord were elevated in rats following CFA treatment and CCI induction, and obtusifolin and gluco-obtusifolin significantly inhibited these effects. Our results demonstrate that obtusifolin and gluco-obtusifolin produce significant antinociceptive action in rodent behavioral models of inflammatory/neuropathic pain, and that this activity is associated with modulation of neuroinflammation in spinal cord.

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Pharmacological correlation between the formalin test and the neuropathic pain behavior in different species with chronic constriction injury

Cited by 41 publications

References 51 publications

Depression-like behavior and mechanical allodynia are reduced by bis selenide treatment in mice with chronic constriction injury: a comparison with fluoxetine, amitriptyline, and bupropion

Depression-like behavior and mechanical allodynia are reduced by bis selenide treatment in mice with chronic constriction injury: a comparison with fluoxetine, amitriptyline, and bupropion

A novel automated method for measuring the effect of analgesics on formalin-evoked licking behavior in rats

Anti-allodynic Effects of Obtusifolin and Gluco-Obtusifolin against Inflammatory and Neuropathic Pain

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