Pharmacological Doses of Triiodothyronine Upregulate Lipogenic Enzyme Gene Expression in Rat White Adipose Tissue

Zabrocka, Lidia; Klimek, Jerzy; Świerczyński, Julian

doi:10.1055/s-2006-925114

Cited by 8 publications

(8 citation statements)

References 20 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…Glucose transport was differentially regulated with a significant upregulation of GLUT4 in WAT but not in other tissues. It supports well-known data on T3-related effects on FFA increase, an induction of hepatic, WAT, BAT and muscle-related gluconeogenesis and glycogenolysis [26,27,28,29,30,31,32,33]. This is further exemplified by data on the local availability of T3.…”

Section: Thyroid and Energy Regulation: Pathophysiological Consideratsupporting

confidence: 88%

Thyroid Hormones and the Metabolic Syndrome

2013

View full text Add to dashboard Cite

Background: Clustering of various metabolic parameters including abdominal obesity, hyperglycaemia, low high-density lipoprotein cholesterol, elevated triglycerides and hypertension have been used worldwide as metabolic syndrome to predict cardiometabolic risk. Thyroid dysfunction impacts on various levels of these components. Objectives: The purpose of the present review is to summarize available data on thyroid hormone-dependent action on components of the metabolic syndrome. Methods: A PubMed search for any combination of hyperthyroidism, thyrotoxicosis or hypothyroidism and metabolic syndrome, blood pressure, hypertension, hyperlipidaemia, cholesterol, high-density lipoprotein cholesterol, glucose, diabetes mellitus, body weight or visceral fat was performed. We included papers and reviews published between 2000 and today but accepted also frequently cited papers before 2000. Results: There is convincing evidence for a major impact of thyroid function on all components of the metabolic syndrome, reflecting profound alterations of energy homeostasis at many levels. Conclusion: Even though the interactions shown in animal models and man are complex, it is evident that insulin sensitivity is highest and adverse thyroid effects on the metabolic system are lowest in euthyroid conditions.

show abstract

Section: Thyroid and Energy Regulation: Pathophysiological Consideratsupporting

confidence: 88%

Thyroid Hormones and the Metabolic Syndrome

2013

View full text Add to dashboard Cite

show abstract

“…One experimental animal study reported that SREBP1c transcription was negatively regulated by TH via a putative negative thyroid hormone response element (nTRE) [36], but another study has shown that SREBP1c transcription is upregulated by non-genomic thyroid hormone signaling [37]. In our current study, the expressions of some hepatic TH-responsive proteins were sharply enhanced, such as SREBP1c, ACL [38], HMGCS1 [9], which are consistent with the promotions of fatty acid and cholesterol synthesis, respectively (Fig. 4A, 4B and 4D).…”

Section: Discussionmentioning

confidence: 48%

Gestational hypothyroidism elicits more pronounced lipid dysregulation in mice than pre-pregnant hypothyroidism

et al. 2020

View full text Add to dashboard Cite

Thyroid hormone is crucial for regulating lipid and glucose metabolism, which plays essential role in maintaining the health of pregnant women and their offspring. However, the current literature is just focusing on the development of offspring born to the untreated mothers with hypothyroidism, rather than mothers themselves. Additionally, the interaction between hypothyroidism and pregnancy, and its impact on the women's health are still elusive. Therefore, this study was designed to compare the metabolic differences in dams with hypothyroidism starting before pregnancy and after pregnancy. Pre-pregnant hypothyroidism was generated in 5-week-old female C57/BL/6J mice using iodine-deficient diet containing 0.15% propylthiouracil for 4 weeks, and the hypothyroidism was maintained until delivery. Gestational hypothyroidism was induced in dams after mating, using the same diet intervention until delivery. Compared with normal control, gestational hypothyroidism exhibited more prominent increase than pre-pregnant hypothyroidism in plasma total cholesterol and lowdensity lipoprotein cholesterol, and caused hepatic triglycerides accumulation. Similarly, more significant elevations of protein expressions of SREBP1c and p-ACL, while more dramatic inhibition of CPT1A and LDL-R levels were also observed in murine livers with gestational hypothyroidism than those with pre-pregnant hypothyroidism. Moreover, the murine hepatic levels of total cholesterol and gluconeogenesis were dramatically and equally enhanced in two hypothyroid groups, while plasma triglycerides and protein expressions of p-AKT, p-FoxO1 and APOC3 were reduced substantially in two hypothyroid groups. Taken together, our current study illuminated that gestational hypothyroidism may elicit more pronounced lipid dysregulation in dams than dose the pre-pregnant hypothyroidism.

show abstract

“…Interestingly, the same dose of T 3 up-regulated the expression of the malic enzyme gene (Figs. 4 and 5) and genes encoding other lipogenic enzymes (Zabrocka et al, 2006) in white adipose tissue. This suggests that the inhibitory effect of T 3 on leptin gene expression is rather specific but not a consequence of toxic action of the hormone on the adipose tissue.…”

Section: Discussionmentioning

confidence: 99%