Pharmacological effects and mechanisms of tannic acid

Wang, Jing; Chen, Xiaolan; Chen, Yu; Feng, Qinglai; Yang, Haifeng

doi:10.1016/j.biopha.2022.113561

Cited by 115 publications

(49 citation statements)

References 159 publications

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“…Furthermore, several earlier studies have shown that tannic acid has antiviral activity against different viruses (Konowalchuk and Speirs, 1975;Kaczmarek, 2020), and botanic tannic acid-derived clinical therapy has shown activity against two coronaviral strains, SARS-CoV-2 and HCoV-OC43, which are the earliest-known coronaviruses (Shih et al, 2022). According to previous literature, antibacterial and antibiofilm activity has also been reported from tannic acid (Dong et al, 2018;Jing et al, 2022). Chung et al (Chung et al, 1993) described the growth inhibition of tannic acid against 15 different bacterial cells, including E. coli and S. aureus.…”

Section: Discussionmentioning

confidence: 95%

Inspired by nature: Fiber networks functionalized with tannic acid and condensed tannin-rich extracts of Norway spruce bark show antimicrobial efficacy

Jyske

Liimatainen

Tienaho

et al. 2023

Front. Bioeng. Biotechnol.

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This study demonstrated the antibacterial and antiviral potential of condensed tannins and tannic acid when incorporated into fiber networks tested for functional material purposes. Condensed tannins were extracted from industrial bark of Norway spruce by using pressurized hot water extraction (PHWE), followed by purification of extracts by using XADHP7 treatment to obtain sugar-free extract. The chemical composition of the extracts was analyzed by using HPLC, GC‒MS and UHPLC after thiolytic degradation. The test matrices, i.e., lignocellulosic handsheets, were produced and impregnated with tannin-rich extracts, and tannic acid was used as a commercial reference. The antibacterial and antiviral efficacy of the handsheets were analyzed by using bioluminescent bacterial strains (Staphylococcus aureus RN4220+pAT19 and Escherichia coli K12+pCGLS11) and Enterovirus coxsackievirus B3. Potential bonding of the tannin-rich extract and tannic acid within the fiber matrices was studied by using FTIR-ATR spectroscopy. The deposition characteristics (distribution and accumulation patterns) of tannin compounds and extracts within fiber networks were measured and visualized by direct chemical mapping using time-of-flight secondary ion mass spectrometry (ToF-SIMS) and digital microscopy. Our results demonstrated for the first time, how tannin-rich extracts obtained from spruce bark side streams with green chemistry possess antiviral and antibacterial properties when immobilized into fiber matrices to create substitutes for plastic hygienic products, personal protection materials such as surgical face masks, or food packaging materials to prolong the shelf life of foodstuffs and prevent the spread of infections. However, more research is needed to further develop this proof-of-concept to ensure stable chemical bonding in product prototypes with specific chemistry.

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Section: Discussionmentioning

confidence: 95%

Inspired by nature: Fiber networks functionalized with tannic acid and condensed tannin-rich extracts of Norway spruce bark show antimicrobial efficacy

Jyske

Liimatainen

Tienaho

et al. 2023

Front. Bioeng. Biotechnol.

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“…The application of granular hydrogel inhibited local inflammatory response, so as to accelerate wound healing. According to previous studies, 35,36 TA not only shows biocompatibility, but also possesses anti-inflammatory property. Therefore, TA combined with collagen could fabricate bioactive materials with various potential for medical applications.…”

Section: Application Of Colmg@ta@nha Granular Hydrogel In Wound Healingmentioning

confidence: 90%

Construction of injectable collagen-microgel/tannic acid/nano-hydroxyapatite granular hydrogel and evaluation of its potential in wound healing

Bai

Ren

et al. 2023

Journal of Bioactive and Compatible Polymers

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Granular hydrogel is a kind of hydrogel assembled from micro-particles, possessing micro-porous structure that advanced in terms of exudate absorption, mass exchange and cell migration during wound healing. The present study fabricated an injectable granular hydrogel based on tannic acid (TA) connected collagen (COL)-microparticles and hydroxyapatite nanoparticles (nHA). Through the coordination of calcium and phenolic hydroxyl groups, TA was bound on nHA surface to form TA modified nano-hydroxyapatite, TA@nHA. The content of TA bound on nHA surface was as high as 30%. TA@nHA as high as 20% was used as giant crosslinking component to connect COL microgels (COLmg) via hydrogen bond, forming COLmg@TA@nHA granular hydrogel. The size of COL microgels could be controlled via adjusting stirring speed. The larger COL microgels assembled granular hydrogel possessed higher porosity. While the smaller COL microgels assembled granular hydrogel was more stable, showing better self-healing ability in rheological test. Due to the dynamically reversible interactions, COLmg@TA@nHA granular hydrogel was injectable, which could be applied to the skin wound, exhibiting the ability to inhibit inflammatory response, while enhance α-SMA expression, promoting wound healing. The method to fabricate granular hydrogel introduced in this study has a broad scalability toward repairing various tissues.

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“…Besides, terpenes and its main three subtype such as monoterpenes and sesquiterpenes, diterpenes, and triterpenes all possesses an potential anti-in ammatory analgesic activity [38]. Tannins had been proved to have a signi cant central acting and periphery analgesic effects [39].…”

Section: Discussionmentioning

confidence: 99%

Antinociceptive and Anti-Urolithiatic Effects of Ensete glaucum (Roxb.) Cheesman Seed Aqueous Extract in Mice

Le¹,

Ly²,

Le³

2023

Preprint

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Ensete glaucum seeds, being known as one of traditional medicine, are commonly used in folk medicine to treat urinary stones, edema, and osteoarthritis-related problems. However, no scientific evidence has been reported to support these uses. This study focused on investigating the antinociceptive and antiurolithiatic activities of E. glaucum seed aqueous extract (EGE). The antinociceptive effect of EGE was evaluated in mice using thermal (hot plate test) and chemical (acetic acid and formalin-induced nociception test) pain models at various doses (50, 100, 200, 400 mg/kg; p.o.). The anti-urolithiatic activity of the EGE (200, 400 mg/kg; p.o.) was assessed in the sodium glyoxylate-induced urolithiasis in mice and in vitro nucleation and aggregation assays. The analgesic effect of EGE was detected at several doses via peripheral and central antinociceptive mechanisms in the acetic acid-induced writhing (50-400 mg/kg), hot plate (100-200 mg/kg), and formalin-induced licking (200-400 mg/kg) tests. EGE had potential against urolithiasis through its ability to modify several serum and urine biochemical parameters on glyoxylate-induced nephrolithiasis. The extract at the dose of 400 mg/kg significantly improved the inflammatory cells, kidney tissue structure, and renal calcification. The extract also exhibited significant anti-urolithiatic, anti-inflammatory, and antioxidant activities in some in vitro models. These outcomes suggest that E. glaucum aqueous seed extract possesses antinociceptive activity and may aid in the prevention of urinary stones. Further studies are needed to elucidate the effectiveness of E. glaucum seeds in the analgesic activity and management of urolithiasis disease.

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Pharmacological effects and mechanisms of tannic acid

Cited by 115 publications

References 159 publications

Inspired by nature: Fiber networks functionalized with tannic acid and condensed tannin-rich extracts of Norway spruce bark show antimicrobial efficacy

Inspired by nature: Fiber networks functionalized with tannic acid and condensed tannin-rich extracts of Norway spruce bark show antimicrobial efficacy

Construction of injectable collagen-microgel/tannic acid/nano-hydroxyapatite granular hydrogel and evaluation of its potential in wound healing

Antinociceptive and Anti-Urolithiatic Effects of Ensete glaucum (Roxb.) Cheesman Seed Aqueous Extract in Mice

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