Pharmacological effects and toxicity of Costus pulverulentus C. Presl (Costaceae)

Alonso-Castro, Ángel Josabad; Zapata-Morales, Juan Ramón; González‐Chávez, Marco Martín; Carranza‐Álvarez, Candy; Hernández-Benavides, Diego Manuel; Morales, Alejandro

doi:10.1016/j.jep.2016.01.011

Cited by 16 publications

(9 citation statements)

References 18 publications

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“…The most abundant compound in the ethanolic extract of C. pulverulentus was D-psychofuranose with a retention time (RT) of 26.46 m and relative abundance of 9.74% (Table 3), while, among the organic acids, the phydroxy-cinnamic with TR of 27.41 was the most abundant with a relative abundance of 6.79%. This compound has been previously reported in ethanolic extract of C. pulverulentus in 7.38% (Alonso-Castro et al 2016). Hydroxycinnamic acid is a phenolic compound that acts as an antioxidant and inhibitor of the action of free radicals.…”

Section: Preparation Of the Ethanolic Extract Of C Pulverulentussupporting

confidence: 60%

Antibacterial activity of Costus pulverulentus (Costaceae) C. Presl

Ramiro-Bautista

Morales

Carranza‐Álvarez

et al. 2020

JNAS

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Antimicrobial resistance is a great concern in public health. Therefore, it is necessary to obtain new compounds to treat diseases caused by bacteria. Medicinal plants are an alternative to search natural compounds to improve human health, including antioxidants, anti-inflammatory, and antimicrobials compounds. Costus pulverulentus (Costaceae) C. Presl is a plant used traditionally in Huasteca Potosina to treat bacterial infections. However, the compounds involved in this activity remain poorly understood. To determine the antibacterial activity of C. pulverulentus, an ethanolic extract was obtained. Plant stem was macerated in ethanol and then was fractionated with hexane, chloroform, ethyl acetate, acetone, ethanol, and methanol. Ethanolic extract and derived fractions were tested against bacteria by the disk-diffusion agar method. The results showed that the ethanolic extract of C. pulverulentus exerted activity against Chromobacterium violaceum CV026 and Bacillus sp. at 10 and 30 μg/disk, whereas only the methanolic fraction showed similar activity to complete extract. Fraction 8 obtained from methanolic fraction showed inhibitory activity against Bacillus sp., S. aureus, and S. aureus Oxacillin resistant. Gas Chromatography-Mass Spectrometry characterization of active fraction 8 showed that it contains vanillic acid and pcoumaric acid suggesting that they are involved in the antibacterial activity of C. pulverulentus.

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Section: Preparation Of the Ethanolic Extract Of C Pulverulentussupporting

confidence: 60%

Antibacterial activity of Costus pulverulentus (Costaceae) C. Presl

Ramiro-Bautista

Morales

Carranza‐Álvarez

et al. 2020

JNAS

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“…selectively restrained the growth of prostate-cancer-associated broblasts (CAFs) by stimulating autophagy in prostate-CAFs via the activation of Beclin-1 and LC3 (key autophagy proteins) and thus developing the effectiveness of cancer therapy [156]. Costus pulverulentus ethanol extract of the stem (campesterol, stigmasterol β-sitosterol, vanillic acid, among other components) presented moderate cytotoxic effects on PC-3 cells (IC 50 = 179 µg/mL) and induced DNA damage in the comet assay at 200 µg/mL or higher concentrations [129]. The study of Ficus deltoidea var.…”

Section: Plant Extracts and Plant-derived Bioactives In Prostate Cmentioning

confidence: 99%

Phytochemicals in Prostate Cancer: From Bioactive Molecules to Upcoming Therapeutic Agents

et al. 2019

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Prostate cancer is a heterogeneous disease, the second deadliest malignancy in men and the most commonly diagnosed cancer among men. Traditional plants have been applied to handle various diseases and to develop new drugs. Medicinal plants are potential sources of natural bioactive compounds that include alkaloids, phenolic compounds, terpenes, and steroids. Many of these naturally-occurring bioactive constituents possess promising chemopreventive properties. In this sense, the aim of the present review is to provide a detailed overview of the role of plant-derived phytochemicals in prostate cancers, including the contribution of plant extracts and its corresponding isolated compounds.

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“…In the age of modern instrumental methods, the analysis of relatively complex molecules of various structurally similar phytosterols is usually performed using chromatography separation of analytes combined with some type of spectrometric detection. There are many scientific reports on determination of phytosterols in various plants, either using gas chromatography [11][12][13], liquid chromatography [14][15][16], or both methods [17]. However, only few reports are available on determination of phytosterols in biological systems of non-plant origin.…”

Section: Analytical Determination Of β-Sitosterolmentioning

confidence: 99%