Pharmacological Effects of Selected Medicinal Plants and Vitamins Against COVID-19

Yedjou, Clément G.; Njiki, Sylvianne; Enow, Juliet; Ikome, Otto; Latinwo, Lekan M.; Long, Richard; Ngnepieba, Pierre; Alò, Richard A.; Tchounwou, Paul B.

doi:10.17303/jfn.2021.7.202

Cited by 9 publications

(19 citation statements)

References 0 publications

Supporting

Mentioning

Contrasting

Order By: Relevance

“…This notion is based on our knowledge that none of the ArtemiC compound exert adverse effects neither in experimental or in clinical use. 27 All the AEs and SAEs are listed in Appendix 15.2.5 and Appendix 15.2.6, respectively. Due to the complexity of COVID‐19 manifestations in the patient population, alongside high frequency of comorbidities, it was not surprising that many AEs and SAEs were reported in the short study period.…”

Section: Resultsmentioning

confidence: 99%

“… 49 The role of oxidative stress in COVID‐19 pathology is further supported by potential positive impact of oral and intravenous glutathione (GSH) and N‐acetylcysteine (NAC) on the cytokine storm and ARDS in COVID‐19 patients. 50 , 51 Likewise, ascorbic acid (vitamin C) and curcumin exert various pharmacological effects including anti‐bacterial, anti‐cancer, anti‐inflammatory, immuno‐modulatory, anti‐oxidant, anti‐fungal, anti‐mutagenic, and anti‐viral activities, 52 which may have contributed to the obtained beneficial effects of ArtemiC. One of the remarkable effects of vitamin C is its ability to inhibit various forms of T cell apoptosis.…”

Section: Discussionmentioning

confidence: 99%

“… 37 Therefore, it is reasonable to assume that ArtemiC acts as a new therapeutic agent against the deleterious impact of SARS‐CoV‐2. 32 , 33 , 50 , 52 , 53 …”

Section: Discussionmentioning

confidence: 99%

See 2 more Smart Citations

Effect of ArtemiC in patients with COVID‐19: A Phase II prospective study

Hellou

Mohsin

Elemy

et al. 2022

J Cellular Molecular Medi

View full text Add to dashboard Cite

Despite intensive efforts, there is no effective remedy for COVID‐19. Moreover, vaccination efficacy declines over time and may be compromised against new SARS‐CoV‐2 lineages. Therefore, there remains an unmet need for simple, accessible, low‐cost and effective pharmacological anti‐SARS‐CoV‐2 agents. ArtemiC is a medical product comprising artemisinin, curcumin, frankincense and vitamin C, all of which possess anti‐inflammatory and anti‐oxidant properties. The present Phase II placebo‐controlled, double‐blinded, multi‐centred, prospective study evaluated the efficacy and safety of ArtemiC in patients with COVID‐19. The study included 50 hospitalized symptomatic COVID‐19 patients randomized (2:1) to receive ArtemiC or placebo oral spray, twice daily on Days 1 and 2, beside standard care. A physical examination was performed, and vital signs and blood tests were monitored daily until hospital discharge (or Day 15). A PCR assessment of SARS‐CoV‐2 carriage was performed at screening and on last visit. ArtemiC improved NEWS2 in 91% of patients and shortened durations of abnormal SpO 2 levels, oxygen supplementation and fever. No treatment‐related adverse events were reported. These findings suggest that ArtemiC curbed deterioration, possibly by limiting cytokine storm of COVID‐19, thus bearing great promise for COVID‐19 patients, particularly those with comorbidities.

show abstract

Section: Resultsmentioning

confidence: 99%

Section: Discussionmentioning

confidence: 99%

See 1 more Smart Citation

Effect of ArtemiC in patients with COVID‐19: A Phase II prospective study

Hellou

Mohsin

Elemy

et al. 2022

J Cellular Molecular Medi

View full text Add to dashboard Cite

show abstract

“…Vitamin C was employed in 2003 during the SARS-CoV-1 emergence and as a nonspecific therapy for various respiratory tract infections [ 127 ]. Administering vitamin C to patients is an efficacious and economic scheme for the COVID-19 pandemic.…”

Section: Major Food Groups Efficient In Covid-19 Pathogenesismentioning

confidence: 99%

Role of Diet and Nutrients in SARS-CoV-2 Infection: Incidence on Oxidative Stress, Inflammatory Status and Viral Production

et al. 2022

View full text Add to dashboard Cite

Coronavirus illness (COVID-19) is an infectious pathology generated by intense severe respiratory syndrome coronavirus 2 (SARS-CoV-2). This infectious disease has emerged in 2019. The COVID-19-associated pandemic has considerably affected the way of life and the economy in the world. It is consequently crucial to find solutions allowing remedying or alleviating the effects of this infectious disease. Natural products have been in perpetual application from immemorial time given that they are attested to be efficient towards several illnesses without major side effects. Various studies have shown that plant extracts or purified molecules have a promising inhibiting impact towards coronavirus. In addition, it is substantial to understand the characteristics, susceptibility and impact of diet on patients infected with COVID-19. In this review, we recapitulate the influence of extracts or pure molecules from medicinal plants on COVID-19. We approach the possibilities of plant treatment/co-treatment and feeding applied to COVID-19. We also show coronavirus susceptibility and complications associated with nutrient deficiencies and then discuss the major food groups efficient on COVID-19 pathogenesis. Then, we covered emerging technologies using plant-based SARS-CoV-2 vaccine. We conclude by giving nutrient and plants curative therapy recommendations which are of potential interest in the COVID-19 infection and could pave the way for pharmacological treatments or co-treatments of COVID-19.

show abstract

“…Several investigators have proposed that nutrients may play a role in preventing or controlling acute respiratory tract infections 1 or COVID-19. 2 COVID-19 may also be associated with a loss of biodiversity 3 and gut microbiota changes. 3 The COVID-19 pandemic has opened fraught questions of equity on how the world has handled the pandemic.…”

Section: Introductionmentioning

confidence: 99%

Available and affordable complementary treatments for COVID‐19: From hypothesis to pilot studies and the need for implementation

Bousquet

Haahtela

Blain

et al. 2022

Clinical & Translational All

View full text Add to dashboard Cite

Vaccination is a highly effective preventive measure against COVID‐19. However, complementary treatments are needed to better control the disease. Fermented vegetables and spices, agonists of the antioxidant transcription factor nuclear factor (erythroid‐derived 2)‐like 2 (Nrf2) and TRPA1/V1 channels (Transient Receptor Potential Ankyrin 1 and Vanillin 1), may help in the control of COVID‐19. Some preliminary clinical trials suggest that curcumin (spice) can prevent some of the COVID‐19 symptoms. Before any conclusion can be drawn and these treatments recommended for COVID‐19, the data warrant confirmation. In particular, the benefits of the foods need to be assessed in more patients, through research studies and large trials employing a double‐blind, placebo‐controlled design.

show abstract

Pharmacological Effects of Selected Medicinal Plants and Vitamins Against COVID-19

Cited by 9 publications

References 0 publications

Effect of ArtemiC in patients with COVID‐19: A Phase II prospective study

Effect of ArtemiC in patients with COVID‐19: A Phase II prospective study

Role of Diet and Nutrients in SARS-CoV-2 Infection: Incidence on Oxidative Stress, Inflammatory Status and Viral Production

Available and affordable complementary treatments for COVID‐19: From hypothesis to pilot studies and the need for implementation

Contact Info

Product

Resources

About