Pharmacological effects of tiludronate in horses after long-term immobilization

Delguste, Catherine; Amory, Hélène; Doucet, Michèle; Piccot-Crézollet, Cyrille; Thibaud, Dominique; Garnero, Patrick; Detilleux, Johann; Lepage, Olivier

doi:10.1016/j.bone.2007.05.005

Cited by 49 publications

(52 citation statements)

References 23 publications

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“…There is evidence that administration of tiludronate to the horse decreases bone resorption [4]. There is evidence that administration of tiludronate to the horse decreases bone resorption [4].…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of tiludronate in horses: A field population study

Popot¹,

Jacobs

Garcia³

et al. 2018

Equine Veterinary Journal

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Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of tiludronate in horses: A field population study

Popot¹,

Jacobs

Garcia³

et al. 2018

Equine Veterinary Journal

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“…378 Horses were immobilized for 8 weeks, followed by a 4-week remobilization period and an 8-week standardized findings and also indicate that bone deposition rate is increased with training. A study evaluated tiludronate, a bisphosphonate, on biochemical biomarkers of bone metabolism and on bone density and structure in a model of disuse osteoporosis induced by cast application in horses.…”

Section: Adaptation Of Bone To Increased Stressmentioning

confidence: 99%

Responses of Musculoskeletal Tissues to Disuse and Remobilization

Millis¹

2014

Canine Rehabilitation and Physical Therapy

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P atients afflicted with neurologic, orthopedic, metabolic, and other diseases frequently have reduced weight bearing and use of limbs. In addition, some conditions may be treated with splints, casts, or other coaptation devices, resulting in decreased limb use. The tissues most affected by disuse and immobilization are cartilage, joint capsule, muscle, ligament, tendon, and bone. Knowledge of how these tissues respond to disuse and immobilization, the types of deleterious tissue changes, and the time frame over which these changes occur, are important in understanding the need for physical rehabilitation. For example, stress deprivation of joints results in proliferation of connective tissue within the joint space, adhesions between synovial folds, adherence of connective tissue to cartilage surfaces, atrophy of cartilage, reduced proteoglycan (PG) content, ulceration at points of cartilage to cartilage contact, disorganization of cellular and fibrillar ligament alignment, reduced collagen mass, increased ligament compliance, weakened ligament insertion sites, reduced load-to-failure and energy-absorbing capacity of the bone-ligament-bone complex, and osteoporosis of the involved extremity. 1 Rehabilitation of patients with acute or chronic neurologic or orthopedic conditions involves the application of controlled challenges to tissues to improve strength, condition, and function. It is important to understand how to safely remobilize tissues after injury and a period of immobilization. Rehabilitation must sufficiently challenge tissues to enhance and positively influence their recovery and healing. However, if tissues are overchallenged, they may be damaged, ultimately delaying recovery or cause additional injury. There must be a balance between the simultaneous demands for protection against undue stress to facilitate healing, and the need for stress to attenuate atrophy of musculoskeletal tissues. 2 A review of these concepts forms the basis for a rational approach to developing rehabilitation programs. CartilageDisorders of articular cartilage and joints are some of the most common and debilitating diseases encountered in veterinary practice. Understanding the normal structure and function of articular cartilage is a prerequisite to understanding the pathologic processes. The mechanical properties of articular cartilage arise from the complex structure and interactions of its biochemical constituents. The viscoelastic properties of cartilage, primarily resulting from fluid flow through the solid matrix, explain deformational responses observed during loading. For example, cartilage that is loaded rapidly is stiffer than the same cartilage that is loaded slowly. Degenerative processes include the breakdown of normal constituents of cartilage, especially the collagen network and PGs, which affects the mechanics of fluid flow through cartilage. Factors contributing to such breakdown include direct trauma, obesity, immobilization, and excessive repetitive loading of the cartilage. Training activities, without tr...

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“…Currently tiludronate (a bisphosphonate) is widely used for similar bone pathologies in horses (Denoix et al 2003, Schulze 2005, Delguste et al 2007). The most important mechanism of action of bisphosphonates is to regulate bone metabolism through inhibition of bone resorption (Fleisch 1998).…”

Section: Introductionmentioning

confidence: 99%

Effects of Calcium dobesilate on horses with an increased signal intensity in the navicular bone in fat suppressed images on MRI: Pilot study

Janssen¹,

Mair²,

Reardon³

et al. 2011

PHK

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SummaryEarly stages of navicular disease (ND) in horses have been observed to be associated with chronic lameness. These early stages of disease have been recognised as increased signal intensity in fat suppressed images in the spongiosa of the navicular bone (NB). Calcium dobesilate (CD) has an effect on pressure dynamics in the subchondral bone of osteoarthritic joints of rabbits and could potentially be used as a treatment for the early stages of ND in horses. The aim of this pilot study was to monitor the lameness and the MRI changes in 12 horses diagnosed with chronic foot pain and demonstrating increased signal intensity in fat suppressed images in the spongiosa of the NB. Twelve horses with fore foot lameness of between one month and two year's duration were selected for the study. Inclusion criteria were: absence of radiographic findings on standard foot radiographs and an increased signal intensity in fat suppressed images in the spongiosa of the NB without concurrent lesions detected on MRI scans of the foot. Horses were treated with CD and a controlled exercise regimen and were re-evaluated clinically and with MRI two and four months after diagnosis. In 10 of 12 horses (83 %) lameness improved between the first and second examination and in 10 horses (91%) between the first and third examinations. Eight of 12 horses were sound at the end of the trial. There was a general trend for reduction in the severity of MRI abnormalities during the study period. Calcium dobesilate is a potential treatment option for horses with foot pain associated with increased signal intensity in fat suppressed images in the spongiosa of the NB. The results of this pilot study suggest that a double blind controlled clinical trial into the effectiveness of CD is warranted. Pferde mit Vorderhandlahmheiten selektiert, die Lahmheitsdauer beschränkte sich auf einen Monat bis zwei Jahre. Einschlusskriterien waren: Keine röntgenologischen Veränderungen in den Standard Projektionen und ausschließlich ein im MRT erhöhtes fettunterdrücktes Signal im Strahlbein ohne gleichzeitig auftretende Defekte im MRT in der distalen Pferdegliedmaße. Die Pferde wurden mit Calcium dobesilat behandelt und nach einem einheitlichen kontrollierten Plan bewegt. Nach gestellter Diagnose erfolgte eine klinische und eine MRT-Nachuntersuchung im zweiten und im vierten Monat. Zwischen der ersten und der zweiten Untersuchung zeigten 10 von 12 Pferden (83%), zwischen der zweiten und der dritten Untersuchung zeigten 10 Pferde (91%) eine reduzierte Lahmheit. Am Ende der Pilotstudie waren 8 von 12 Pferden lahmheitsfrei. Während der Pilotstudie konnte im MRT eine Tendenz für eine Reduktion des fettunterdrückten Signals im Strahlbein festgestellt werden. Calcium dobesilat ist eine potentielle Behandlungsoption bei Pferden mit einem im MRT erhöhten fettunterdrücktem Signal im Strahlbein. Die Ergebnisse dieser Pilotstudie berechtigen eine Durchführung einer Doppelblindstudie zur weiteren Untersuchung der Effektivität von Calcium dobesilat.Schlüsselwörter: Pferd / Strah...

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Pharmacological effects of tiludronate in horses after long-term immobilization

Cited by 49 publications

References 23 publications

Pharmacokinetics of tiludronate in horses: A field population study

Pharmacokinetics of tiludronate in horses: A field population study

Responses of Musculoskeletal Tissues to Disuse and Remobilization

Effects of Calcium dobesilate on horses with an increased signal intensity in the navicular bone in fat suppressed images on MRI: Pilot study

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