Pharmacological evaluation for Anti-Anxiety and CNS depressant activity of hydro-alcoholic leaves extract of Pongamia pinnata

Abstract

The aim of this study was to assess the anti-anxiety and CNS depressant properties of hydro-alcoholic extract of Pongamia pinnata leaves (HALEPP). Standard methods were used to screen the HALEPP's phytochemicals, which showed that the extract contains Flavones, alkaloids, glycosides, proteins and amino acids, gum and mucilage as well as flavonoids, saponins, and steroid hormones. Even at the dose level of 1000 mg/kg body weight, the HALEPP showed no signs of toxicity or mortality in the acute toxicity report. The anti-anxiety behaviour of was studied using light and dark model methods in rats. The CNS depressant action was studied using the extract and actophotometer (Rolex) in rats. The research group (HALEPP 200 gm/kg treated) animals displayed strong anti-anxiety and CNS depressant behaviour similar to the control group (diazepam treated) animals in the current study. The study's findings suggest that the hydro-alcoholic Pongamia pinnata leaf extract has strong anti-anxiety and CNS depressant properties.
 Keywords: Pongamia pinnata, Anti-Anxiety & CNS depressant