Pharmacological evidence favouring the use of Nauclea latifolia in malaria ethnopharmacy: Effects against nociception, inflammation, and pyrexia in rats and mice

In vitro antiplasmodial activity and cytotoxicity of nine plants traditionally used in Gabon

“…These results are consistent with other published data from central West Africa (Traore-Keita et al, 2000;Zirihi et al, 2005). Although the active components have yet to be identified, this plant shows hypoglycemic, anticonvulsant, anxiolytic, antinociceptive, anti-inflammatory and anti-pyretic properties that justify its use to treat malaria symptoms (Gidado et al, 2008;Ngo Bum et al, 2009;Abbah et al, 2010). Compounds with antifungal properties have also been isolated from Nauclea latifolia (Ata et al, 2009).…”

Antipyretic and antinociceptive effects ofNauclea latifoliaroot decoction and possible mechanisms of action

“…Previous works have shown that the aqueous extract of the bark of Nauclea latifolia (freeze-dried extract) attenuated writhing episodes induced by acetic acid and increased the threshold for pain perception in the hot-plate test in mice. The extract remarkably decreased both the acute and delayed phases of formalin-induced pain in rats and also caused a significant reduction in both yeast-induced pyrexia and egg albumin-induced edema in rats (Abbah et al, 2009). In the course of pharmacological studies, anticonvulsant, anxiolytic and sedative properties of Nauclea latifolia root decoction (Ngo Bum et al, 2009) have already been reported from this laboratory.…”

“…Nauclea latifolia root decoction is a herbal preparation that has been used traditionally for treating different disease conditions. Medicinal uses vary from one traditional setting to another, and include: fever, pain, dental caries, septic mouth, malaria, dysentery, diarrhea, and diseases of the central nervous system such as epilepsy (Arbonnier, 2000, Amos et al, 2005Ngo Bum et al, 2009;Abbah et al, 2009). The root of Nauclea latifolia is the preferred part of…”

A Comprehensive Evaluation of Peripheral Analgesic and Antipyretic Activities of Divalent Metal Complexes of Indomethacin

“…Antipyretic activity of metal complexes of indomethacin was studied in rats having fever induced by 15% Brewer's yeast. 23,24 It is considered as a useful test for the screening of synthetic drugs for their antipyretic effect. 25 Before experimentation, the basal rectal temperatures of the animals were measured by using a clinical digital thermometer.…”