Pharmacological interventions for recurrent abdominal pain in childhood

Martin, Alice; Newlove‐Delgado, Tamsin; Abbott, Rebecca; Bethel, Alison; Thompson-Coon, Jo; Whear, Rebecca; Logan, Stuart

doi:10.1002/14651858.cd010973.pub2

Cited by 33 publications

(16 citation statements)

References 75 publications

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“…One additional paper 38 was a summary of 3 other included systematic reviews. 10,39,40 Data extraction and quality ratings were not conducted for the summary review because information was obtained from the original included systematic reviews. Thus, data and quality ratings are reported for 47 unique reviews/clinical practice guidelines.…”

Section: Study Characteristicsmentioning

confidence: 99%

“…Most reviews (n = 19; 40.4%) included variations of mixed chronic pain populations (e.g., abdominal pain, headaches or migraines, widespread pain/fibromyalgia, complex regional pain syndrome, neuropathic pain, sickle cell disease, cancer pain, back pain, and/or pelvic pain). 8,37,[41][42][43][44][45][46][47][48][49][50][51][52][53][54][55][56][57][58] Reviews focused on single populations most frequently examined abdominal pain (n = 10; 21.3%), 10,35,39,40,57,[59][60][61]77,78 headaches or migraines (n = 5; 10.6%), [62][63][64][65][66] rheumatological conditions (e.g., juvenile idiopathic arthritis, lupus; n = 4; 8.5%), [67][68][69][70] cancer-related pain (n = 3; 6.4%), [71][72][73] or sickle cell disease (n = 2; 4.3%). 74,75 Single reviews focused on patellar tendon pain/Osgood-Schlatter's (n = 1; 2.1%), 76 cerebral palsy (n = 1; 2.1%), …”

Section: Types Of Populationsmentioning

confidence: 99%

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Mapping the evidence and gaps of interventions for pediatric chronic pain to inform policy, research, and practice: A systematic review and quality assessment of systematic reviews

Birnie

Ouellette

Amaral

et al. 2020

Canadian Journal of Pain

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Background: Reviews in pediatric chronic pain often focus on only one intervention or population, making it difficult for policymakers and decision makers to quickly synthesize knowledge to inform larger-scale policy and funding priorities. Aims: The aims of this study were to (1) create an evidence and gap map of interventions for pediatric chronic pain and (2) identify gaps between existing evidence and recently identified patient-oriented research priorities. Methods: We performed a systematic review of English-language peer-reviewed systematic reviews or clinical practice guidelines of pediatric chronic pain intervention published in the past 20 years. Database searches of Medline, Embase, PsycINFO, Web of Science, CINAHL, and SCOPUS were conducted inclusive to June 3, 2019. Review quality was assessed using the AMSTAR-2. Results: Of 4168 unique abstracts, 50 systematic reviews (including 2 clinical practice guidelines) crossing diverse pediatric chronic pain populations and intervention settings were included. One third were rated high quality, with half rated low to critically low quality. The largest proportion of reviews addressed psychological and pharmacological interventions, followed by interdisciplinary, other (e.g., dietary), and physical interventions. Most common outcomes included pain, physical, emotional, and role functioning and quality of life. Treatment satisfaction and adverse events were less common, with minimal report of sleep or economic factors. Most patient-oriented research priorities had not been investigated. Conclusions: Sufficient quality evidence is available to guide evidence-informed policies in pediatric chronic pain, most notably regarding psychological and pharmacological interventions. Numerous evidence gaps in patient-oriented research priorities and treatment outcomes should guide prioritization of research funds, as well as study aims and design. RÉSUMÉ Contexte: Les études sur la douleur chronique chez les enfants se concentrent souvent sur une seule intervention ou sur une seule population, de sorte qu'il est difficile pour les responsables politiques et les décideurs de synthétiser rapidement les connaissances afin d'éclairer les priorités de financement et les politiques à plus grande échelle. Objectifs: Les objectifs de cette étude étaient (1) de créer une carte présentant les lacunes dans les données probantes en ce qui concerne les interventions pour la douleur chronique chez les enfants et (2) de répertorier les lacunes dans les données probantes existantes par rapport aux priorités de recherche axées sur le patient récemment déterminées. Méthodes: Nous avons effectué une revue systématique des revues systématiques évaluées par des pairs ou des guides de pratique clinique portant sur les interventions en matière de douleur chronique pédiatrique publiés en langue anglaise au cours des 20 dernières années. Des recherches ont été menées dans les bases de données Medline, Embase, PsycINFO, Web of Science, CINAHL et SCOPUS jusqu'au 3 juin 2019 inclusivement. La qualit...

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Section: Study Characteristicsmentioning

confidence: 99%

Section: Types Of Populationsmentioning

confidence: 99%

Mapping the evidence and gaps of interventions for pediatric chronic pain to inform policy, research, and practice: A systematic review and quality assessment of systematic reviews

Birnie

Ouellette

Amaral

et al. 2020

Canadian Journal of Pain

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“…Mainstay treatment options for FAPDs include conservative medications, alternative medications, diet modification, and psychological therapy [1,13,14]. Recently published Cochrane reviews support psychological therapies over medications for treating FAPDs in children [15,16]. Cognitive behavioral therapies and related therapies such as guided imagery therapy (GIT) appear to be the most efficacious psychological treatments for pediatric patients.…”

Section: Introductionmentioning

confidence: 99%

Maternal and Child Acceptability of a Proposed Guided Imagery Therapy Mobile App Designed to Treat Functional Abdominal Pain Disorders in Children: Mixed-Methods Predevelopment Formative Research

Hollier

Vaughan

Liu

et al. 2018

JMIR Pediatr Parent

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Background Functional abdominal pain disorders are chronic abdominal pain conditions, which affect up to 20% of children worldwide. Of the various functional abdominal pain disorder treatment modalities, psychological therapies such as guided imagery therapy appear most effective. However, there are significant barriers to receiving psychological therapies, including access to trained therapists. Alternatively, remotely delivered psychological therapies for functional abdominal pain disorders have been efficacious. Objective The objective of our study was to assess acceptability of a proposed guided imagery therapy app designed to treat functional abdominal pain disorders through remote delivery of prerecorded audio sessions and to evaluate user preferences for using such an app. Methods Using a mixed-methods approach, we conducted a predevelopment formative study among children aged 7 to 12 years with a functional abdominal pain disorder and their parents. The parents completed our modified Technology Acceptance Model (TAM) questionnaire, which quantified behavioral intention and related factors for using a guided imagery therapy app. Dyads participated in separate in-person semistructured interviews to assess their attitudes toward and preferences for a guided imagery therapy app. Questionnaire and interview findings were collected concurrently, analyzed separately, and then integrated through methods triangulation. Results Among the 15 participating parent-child dyads, 5 (33%) children were Hispanic and 11 (73%) had irritable bowel syndrome. They had diverse socioeconomic status. All parent participants were mothers. The TAM questionnaire indicated that mothers scored favorably on behavioral intention to use a guided imagery therapy app (mean score 12.0, SD 2.6, possible range 3-15). Scores for the TAM factors perceived usefulness, perceived ease of use, hedonic motivation, compatibility, and habit also were favorable. Maternal interviews confirmed positive attitudes toward the proposed app. They advocated a visual component to hold their child’s attention during the guided imagery therapy sessions; recommended incorporating background sounds into the sessions; favored session reminder notifications from the app; and thought the best time for their child to listen to the sessions would be in the evening or before bed. The child interviews also confirmed positive attitudes toward the proposed app. They suggested guided imagery therapy session topics such as sports and adventures; listening to sessions in their bedroom; and the need for parental supervision to install the app on their mobile device. Integration of the quantitative and qualitative methods findings complimented one another on acceptability. The favorable behavioral intention TAM score aligned well with expressed positive maternal and child attitudes toward the app and can be explained by the desire to avoid medications. The questionnaire and in...

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“…Both have methodological flaws and analysis even after combining both studies. The evidence is still insufficient to recommend peppermint oil for the treatment of FAPDs[ 218 ].…”

Section: Management Of Ibsmentioning

confidence: 99%

Irritable bowel syndrome in children: Current knowledge, challenges and opportunities

Devanarayana¹,

Rajindrajith²

2018

WJG

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Irritable bowel syndrome (IBS) is a common and troublesome disorder in children with an increasing prevalence noted during the past two decades. It has a significant effect on the lives of affected children and their families and poses a significant burden on healthcare systems. Standard symptom-based criteria for diagnosis of pediatric IBS have changed several times during the past two decades and there are some differences in interpreting symptoms between different cultures. This has posed a problem when using them to diagnose IBS in clinical practice. A number of potential patho-physiological mechanisms have been described, but so far the exact underlying etiology of IBS is unclear. A few potential therapeutic modalities have been tested in children and only a small number of them have shown some benefit. In addition, most of the described patho-physiological mechanisms and treatment options are based on adult studies. These have surfaced as challenges when dealing with pediatric IBS and they need to be overcome for effective management of children with IBS. Recently suggested top-down and bottom-up models help integrating reported patho-physiological mechanisms and will provide an opportunity for better understanding of the diseases process. Treatment trials targeting single treatment modalities are unlikely to have clinically meaningful therapeutic effects on IBS with multiple integrating patho-physiologies. Trials focusing on multiple combined pharmacological and non-pharmacological therapies are likely to yield more benefit. In addition to treatment, in the future, attention should be paid for possible prevention strategies for IBS.

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Pharmacological interventions for recurrent abdominal pain in childhood

Cited by 33 publications

References 75 publications

Mapping the evidence and gaps of interventions for pediatric chronic pain to inform policy, research, and practice: A systematic review and quality assessment of systematic reviews

Mapping the evidence and gaps of interventions for pediatric chronic pain to inform policy, research, and practice: A systematic review and quality assessment of systematic reviews

Maternal and Child Acceptability of a Proposed Guided Imagery Therapy Mobile App Designed to Treat Functional Abdominal Pain Disorders in Children: Mixed-Methods Predevelopment Formative Research

Irritable bowel syndrome in children: Current knowledge, challenges and opportunities

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