Pharmacological interventions for the prevention of allergic and febrile non-haemolytic transfusion reactions

Martí‐Carvajal, Arturo J; Solà, Iván; González, López; Gonzalez, Graciela Leon de; Rodríguez-Malagón, Nelcy

doi:10.1002/14651858.cd007539.pub2

Cited by 57 publications

(64 citation statements)

References 23 publications

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“…The majority of AEs in patients receiving blood (recipients) manifest either allergy or febrile non-hemolytic transfusion reactions (FNHTRs), both being clearly inflammatory conditions (19). Leukocytes transferred with blood were ascribed to as the principal causes of TT inflammation.…”

Section: Transfusion and Inflammation: From Bedside To Benchmentioning

confidence: 99%

Transfusion as an Inflammation Hit: Knowns and Unknowns

et al. 2016

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Transfusion of blood cell components is frequent in the therapeutic arsenal; it is globally safe or even very safe. At present, residual clinical manifestations are principally inflammatory in nature. If some rare clinical hazards manifest as acute inflammation symptoms of various origin, most of them linked with conflicting and undesirable biological material accompanying the therapeutic component (infectious pathogen, pathogenic antibody, unwanted antigen, or allergen), the general feature is subtler and less visible, and essentially consists of alloimmunization or febrile non-hemolytic transfusion reaction. The present essay aims to present updates in hematology and immunology that help understand how, when, and why subclinical inflammation underlies alloimmunization and circumstances characteristic of red blood cells and – even more frequently – platelets that contribute inflammatory mediators. Modern transfusion medicine makes sustained efforts to limit such inflammatory hazards; efforts can be successful only if one has a clear view of each element’s role.

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Section: Transfusion and Inflammation: From Bedside To Benchmentioning

confidence: 99%

Transfusion as an Inflammation Hit: Knowns and Unknowns

et al. 2016

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“…Risiko reaksi transfusi meningkat dua kali lipat pada waktu penyimpanan darah/komponen 3-5 hari dibandingkan dengan waktu penyimpanan 1-2 hari. 4,7 Reaksi akut alergi ditandai dengan urtikaria atau eritem dengan atau tanpa rasa gatal. Pada keadaan lanjut reaksi alergi ini dapat disertai dengan gejala sistemik seperti sesak, mengi, hipotensi, takikardia, penurunan kesadaran, syok bahkan kematian.…”

Section: -3unclassified

Efektivitas Premedikasi untuk Pencegahan Reaksi Transfusi

Esmeralda

Chozie

2016

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Latar belakang. Penggunaan premedikasi sebelum transfusi meskipun masih digunakan secara luas namun menjadi kontroversi sampai saat ini karena efektivitasnya belum diketahui dengan pasti. Tujuan. Mengetahui efektivitas pemberian premedikasi untuk mencegah reaksi transfusi. Metode. Penelusuran pustaka secara online dengan mempergunakan instrumen pencari Pubmed, Cochrane Library, dan Google. Kata kunci yang digunakan adalah "premedication","transfusion" dan "transfusion reaction". Kata kunci: tranfusi darah, premedikasi, reaksi tranfusi Evidence base case report Effectiveness of Premedication in Preventing Blood Transfusion Reaction Nadia Devina Esmeralda, Novie Amelia ChozieBackground. The use of premedication before blood transfusion is widespread. Yet the efficacy of such premedication has not been rigorously tested and still controversial. Objective. To know the effectivity of premedication in preventing blood transfusion reaction. Methods. Literature search using electronic database: Pubmed, Cochrane Library and Google with key words "premedication","transfusion" dan "transfusion reaction". Results. There are 3 articles regarding premedication prior to transfusion. Retrospective study showed that the incidence of transfusion reaction didn't significantly different by giving acetaminophen and diphenhydramine compare to placebo. Three years prospective study conclude that consumption of premedication can be reduced without increasing transfusion reaction. Cochrane Systematic review showed that allergic reaction in the premedication group had RR 1,45 (0,78-2,72) and fever reaction in this group had RR 0,52 (0,21-1,25). Conclusion. Pretransfusion medications, with any regimen, did not reduced the risk of blood transfusion reactions. Sari Pediatri 2015;17(4):312-6.

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“…Le cas classiquement rapporté de patients déficitaires en IgA sérique manifestant une allergie aux IgA apportés par les fractions plasmatiques des PSL et par le PFC-MDS (les autres MDS sont en principe déplétés en IgA) pose question sur le plan de la physiopathologie et la mécanique de l'allergie : une analyse très récente remet sérieuse-ment la nature allergique de ce déficit IgA [74]. Quelques revues récentes font le point sur le sujet [75,76], mais il semble que ce sujet soit encore largement à explorer sur le plan mécanistique.…”

Section: L'état Des Lieuxunclassified