Pharmacological Investigation of Leaves of Polypodium Decumanum for Antidiabetic Activity

Abstract

This research was performed to characterize the hypoglycemic effect of ethanolic extract of Polypodium decumanum leaves in alloxanized diabetic rats. The ethanolic extract of Polypodium decumanum leaves was administered orally at different doses (250 and 500 mg kg-1) to normal rats. The dose of 500 mg kg-1 was found to be more effective dose in oral route and it decreases Blood Glucose Level (BGL) by 22.2 % in normal healthy rats after 14 days of administration. After daily treatment with the both dose (250 and 500 mg kg-1) of ethanolic Polypodium decumanum extract for 21 days to severely Diabetic (FBG 300-350 mg dL-1) rats, the BGL reduced to 128.2 mg dL-1 by 250 mg kg-1 and 111 mg dL-1 by 500 mg kg-1. The findings of our study indicate the hypoglycemic and potential antihyperglycemic nature of the extract. It is not similar effective when compared with the standard drug Glibenclamide, but quite effective in reducing BGL. It reduces blood glucose level up to 194.1, 119.4, 111 mg dL-1 at successive days of 7, 14, 21, at the dose of 500 mg kg-1 in rats compare with the standard drug which reduces blood glucose level up to 256.6, 140.7, 101.2 mg dL-1. We found that the ethanolic extract of plant Polypodium decumanumleaves is only 10 % less effective in reducing the BGL compare to standard drug (Glibenclamide).

Antimicrobial activities evaluation and phytochemical screening of some selected medicinal plants: A possible alternative in the treatment of multidrug-resistant microbes

“…In another study, an ethanolic extract of Plumbago zeylanica root exhibit good antimicrobial activities against V. cholerae, E. coli, P. aeruginosa, Curvularia lunata, Colletotrichum corchori, and Fusarium equiseti [25]. The aqueous leaf extract of Euphorbia hirta, Erythrophleum suaveolens, and the methanolic leaf extract of Thevetia peruviana has an antibacterial effect against Extended Spectrum Beta-Lactamase (ESBL) producing bacteria such as E. coli, Pseudomonas, K. pneumonia, Methicillin-Resistant Staphylococcus aureus (MRSA), Salmonella and Proteus [26][27][28]. The few studies conducted on the aqueous and hydro-alcoholic extracts from different plants implicate antibacterial effect on multidrug-resistant bacteria including MRSA and ESBL producing bacteria [29,30].…”

“…coli , Pseudomonas , K . pneumonia , Methicillin-Resistant Staphylococcus aureus (MRSA), Salmonella and Proteus [ 26 – 28 ]. The few studies conducted on the aqueous and hydro-alcoholic extracts from different plants implicate antibacterial effect on multidrug-resistant bacteria including MRSA and ESBL producing bacteria [ 29 , 30 ].…”

Exploring Phytochemicals and Pharmacological Uses of Cordia Dichotoma (Indian Cherry): A Review

“…From ancient time plant species are used in the treatment of various diseases 38 . Management of diabetes with agents with no side effects is still a challenge to the medical system.…”

“…Management of diabetes with agents with no side effects is still a challenge to the medical system. There is growing interests in herbal remedies due to these reasons 39,40,41 The effect of the aqueous extract of cordia dichotoma on alloxan induced and normoglycemic Wistar rats have been investigated. Three doses of the extract (250mg/kg; 500 mg/kg and 1000 mg/kg) were administered orally.…”

Antihyperglycemic Activity of Pithecellobium Dules Plant Extracts on Blood Glucose Levels of Streptozocin-Induced Diabetic Rats

“…Oxidative stress is also responsible for the development and progression of diabetes and its complications 3 9 . In India, traditionally numbers of plants are used to manage the diabetic conditions and their active principles were isolated but few plants have been scientifically studied 10,11,12 .…”