Pharmacological Investigations onRhaponticum carthamoides

Abstract

The central neurotropic activity of an aqueous-alcoholic extract from Rhaponticum carthamoides (Wilid.) (Leucea carthamoides D.C.) cultivated in Bulgaria was studied in experiments on albino mice, rats and cats. In doses up to 40 g/kg the extract was non-toxic. Administered in definite doses in mice and rats, it exerted a moderate central stimulating action: increased ambulation and rearing in rats ("open field" test); increased central nervous system excitability ("jumping" test); had a slight antinarcotic effect; improved learning and memory in rats trained in a maze; and increased the physical strength of rats subjected to exhaustive swimming. Administered intraduodenally in cats the extract exerted a hypotensive effect.

Phenylpropanoid Glycosides from Rhodiola rosea.

“…8 Hz and the doublet signal of arabinose anomeric proton H-1Љ had a chemical shift 4.29 ppm with coupling constant 8. 4 Hz. HMBC correlations from H-1Ј to C-9 confirmed the attachment of glucose unit to aglycon, and the position of arabinose unit was confirmed by correlations from H-1Љ to C-6Ј and from H-6Ј b to C-1Љ.…”

“…Collision induced dissociation experiments were performed from 10 mM ammonium acetate solution, colliding [MϩNa] ϩ and [MϩNH 4 ] ϩ ions in positive ion mode and [MϪH] Ϫ ion in negative ion mode with argon gas. The proton-proton coupling constants were obtained from the 1 H spectrum and phase-sensitive COSY spectra and refined with PERCH spectral analysis software.…”

Separation of organic compounds binding trace elements in seeds of Leuzea carthamoides (Willd.) DC

“…According to the IR spectra, higher concentrations of organic acids are found in the methanol + H 2 O fraction (E). These acids were also extracted into fraction D. 20 Table 3. This fraction contained low amounts of cadmium, zinc and lead (1.1-4.7% of total content).…”

“…DC, the Siberian medicinal plant. 19,20 Various important therapeutic compounds (phytoecdysteroids, flavonoids, stilbene, sesquiterpene lactones (guaianolides), polyacetylenes and N-feruloylserotonin isomers) are contained in different parts of this plant. Their role in plant stress metabolism is not fully explained.…”

Preparative purification of salidroside from Rhodiola rosea by two‐step adsorption chromatography on resins

“…Research has shown that this herb has a number of bioactive effects such as antimicrobial [3,4], anti-cancer [5 -8], antidepressant, anti-inflammatory, and antidiabetic effects [9 -11]. It has also been reported to enhance liver regeneration and memory [12,13]. It has been defined as an adaptogen because of its ability to increase the resistance of an organism to environmental stress factors and avoid damage from such factors [14 -16].…”