Phenylpropanoid Glycosides from Rhodiola rosea.

Tolonen, Ari; Pakonen, Minna; Hohtola, Anja; Jalonen, Jorma

doi:10.1248/cpb.51.467

Cited by 85 publications

(54 citation statements)

References 15 publications

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“…The absolute configuration of the aglycones of 1 -3 was not established. The seven known compounds were identified as lobetyol (4) [16], lobetyolin (5) [16], sinapinaldehyde (6) [17], coniferaldehyde (7) [17], coniferoside (8) [18], sachaliside (9) [18], and isoconiferin (10) [19] by comparison of their spectroscopic data ( 1 H-and 13 C-NMR and EI-MS) with those reported in the literature. The antimicrobial properties of compounds 1 -5 were tested against eight microbial strains.…”

mentioning

confidence: 99%

Three New Polyyne (=Polyacetylene) Glucosides from the Edible Roots of Codonopsis cordifolioidea

Mei

Lü

et al. 2008

Helvetica Chimica Acta

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Three new linear C 14 polyyne (¼ polyacetylene) glucosides, cordifolioidynes A -C (1 -3), together with two known polyynes, lobetyol (4) and lobetyolin (5), and five known phenylpropanoids, i.e., sinapinaldehyde (6), coniferaldehyde (7), coniferoside (8), sachaliside (9), and isoconiferin (10), were isolated from the roots of Codonopsis cordifolioidea. The structures of 1 -3 were established from spectral evidences and by characterization of their hydrolysis products. Acid hydrolysis of 1 afforded the aglycone 1a, while hydrolysis of 2 and 3 gave the cyclization products 2a and 3a, respectively. Compounds 4 -10 were isolated from this plant for the first time. The antibacterial activity of compounds 1 -5 were assessed against eight microbial strains by the agar dilution method, none of them exhibited antibacterial effects at concentrations up to 100 mg/ml.

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mentioning

confidence: 99%

Three New Polyyne (=Polyacetylene) Glucosides from the Edible Roots of Codonopsis cordifolioidea

Mei

Lü

et al. 2008

Helvetica Chimica Acta

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“…acetone extract of D. feddei was suspended in H 2 O and partitioned with ethyl acetate. The ethyl acetate partition was repeatedly subjected to column chromatography over Si gel and preparative HPLC (high performance liquid chromatography) to afford compounds 1-12, including three new phenylpropanoids, named feddeiketones A-C (1-3), together with nine known phenylpropanoids, p-coumaric acid (4), 13 caffeic acid (5), 14 ferulic acid (6), 15 coniferoside (7), 16 isoconiferin (8), 17 turbinataphenol A (9), 18 nervolan B (10), 19 nervolan C (11) 20 and 1,2-O-dicaffeoylcyclopenta-3-ol (12). 21 The structures of compounds 1-12 are shown in Figure 1.…”

Section: Resultsmentioning

confidence: 99%

Bioactive phenylpropanoids from Daphne feddei

Lu¹,

Li²,

Mu³

et al. 2012

J. Braz. Chem. Soc.

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A investigação de extrato acetônico de folhas e caules de Daphne feddei forneceu três novos fenilpropanóides, fedeicetonas A-C (1-3), juntamente com nove fenilpropanóides conhecidos (4-11). Suas estruturas foram elucidadas com base em métodos espectroscópicos. Os compostos 1-3 foram testados com relação as suas atividades anti-HIV-1 e citotoxidades frente a células cancerígenas. Os resultados mostraram que as atividades citotóxicas e anti-HIV-1 dos compostos 1-3 são modestas.Investigation of acetone extract of the leaves and stems of Daphne feddei afforded three new phenylpropanoids, feddeiketones A-C (1-3), together with nine known phenylpropanoids (4-11). Their chemical structures were elucidated on the basis of spectroscopic methods. Compounds 1-3 were tested for their anti-HIV-1 activities and cytotoxicities against cancer cells. The results showed that compounds 1-3 have modest cytotoxic and anti-HIV-1 activities.

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“…Total content of phenylpropanoids was 4 087.697 mg/100 g of dry powdered material in the hydroalcoholic extract and 958.517 mg/100 g of dry powdered material in the aqueous extract. The analysis of phenylpropanoid glycosides from Rhodiola rosea by UV, MS and NMR methods was also performed by Tolonen et al [16,17]. Due to the widespread use of Rhodiola material in several countries, the determination of active ingredients such as rosavins, rosin, rosarin and rosaridin is very important for the evaluation of the results of in vivo studies.…”

Section: Discussionmentioning

confidence: 99%

Novel method of detection of phenylpropanoids of Rhodiola roots species

et al. 2013

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S u m m a r yThe aim of the study was the identification and quantitative analysis of phenylpropanoid compounds in the roots of Rhodiola species. Rosavin, rosarin and rosin were determined in the roots of R. kirilowii and R. rosea from the field cultivation, Institute of Natural Fibres and Medicinal Plants. For the quantitative analysis, the ultra performance liquid chromatography -tandem mass spectrometry (UPLC-ESI MS/MS, Waters) was used. The results showed differences in the quantitative and qualitative assessments of these two species. In the root of R. kirilowii the presence of phenylpropanoids was not confirmed. In R. rosea the most common phenylpropanoid was rosavin (0.022%). The UPLC-MS/MS studies allowed to use this analytical method for determination of phenylpropanoids in the accordance with the requirements of ICH.

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Phenylpropanoid Glycosides from Rhodiola rosea.

Cited by 85 publications

References 15 publications

Three New Polyyne (=Polyacetylene) Glucosides from the Edible Roots of Codonopsis cordifolioidea

Three New Polyyne (=Polyacetylene) Glucosides from the Edible Roots of Codonopsis cordifolioidea

Bioactive phenylpropanoids from Daphne feddei

Novel method of detection of phenylpropanoids of Rhodiola roots species

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