Pharmacological manipulation of oxytocin receptor signaling during mouse embryonic development results in sex-specific behavioral effects in adulthood

Aulino, Elizabeth A.; Caldwell, Heather K.

doi:10.1016/j.yhbeh.2021.105026

Cited by 3 publications

(1 citation statement)

References 51 publications

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“…Although it is not known when oxytocin will be expressed, it can be assumed that at least there is a gender specific development of oxytocinergic neurons in a reductionist’s viewpoint [ 154 ]. More broadly, it is also reasonable to assume a role of oxytocin in gender differences in neurodevelopment and consequently adult behaviour [ 154 , 160 ]. Additionally, the density of oxytocin receptors was found to be significantly higher in the female foetal brain [ 154 ].…”

Section: Endogenous Neuromodulators and Pharmacological Agents In Bra...mentioning

confidence: 99%

Role of Brain Modulators in Neurodevelopment: Focus on Autism Spectrum Disorder and Associated Comorbidities

et al. 2022

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Autism spectrum disorder (ASD) and associated neurodevelopmental disorders share similar pathogenesis and clinical features. Pathophysiological changes in these diseases are rooted in early neuronal stem cells in the uterus. Several genetic and environmental factors potentially perturb neurogenesis and synaptogenesis processes causing incomplete or altered maturation of the brain that precedes the symptomology later in life. In this review, the impact of several endogenous neuromodulators and pharmacological agents on the foetus during pregnancy, manifested on numerous aspects of neurodevelopment is discussed. Within this context, some possible insults that may alter these modulators and therefore alter their role in neurodevelopment are high-lighted. Sometimes, a particular insult could influence several neuromodulator systems as is supported by recent research in the field of ASD and associated disorders. Dopaminergic hy-pothesis prevailed on the table for discussion of the pathogenesis of schizophrenia (SCH), atten-tion-deficit hyperactivity disorder (ADHD) and ASD for a long time. However, recent cumulative evidence suggests otherwise. Indeed, the neuromodulators that are dysregulated in ASD and comorbid disorders are as diverse as the causes and symptoms of this disease. Additionally, these neuromodulators have roles in brain development, further complicating their involvement in comorbidity. This review will survey the current understanding of the neuromodulating systems to serve the pharmacological field during pregnancy and to minimize drug-related insults in pa-tients with ASD and associated comorbidity disorders, e.g., SCH or ADHD.

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Section: Endogenous Neuromodulators and Pharmacological Agents In Bra...mentioning

confidence: 99%

Role of Brain Modulators in Neurodevelopment: Focus on Autism Spectrum Disorder and Associated Comorbidities

et al. 2022

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Oxytocin, Vasopressin, and Sex Differences in Social Behavior. It’s Complicated!

Veney,

Caldwell

2024

Masterclass in Neuroendocrinology

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The oxytocin system and early‐life experience‐dependent plastic changes

Onaka

Takayanagi

2021

J Neuroendocrinology

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Oxytocin is mostly synthesized within the hypothalamus and acts mainly on the oxytocin receptor that is expressed in the nervous system and peripheral organs. Oxytocin exerts not only reproduction-related functions such as delivery of children and milk ejection during the lactation period, but also various actions including control of stress-related responses, emotional responses and social behaviour. [1][2][3][4][5][6][7] The oxytocin receptor gene has single-nucleotide polymorphisms (SNPs) and SNPs of the oxytocin receptor gene have been shown to be associated with difference in pair bonding, 8 empathy and stress responsiveness, 9 generous

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Pharmacological manipulation of oxytocin receptor signaling during mouse embryonic development results in sex-specific behavioral effects in adulthood

Cited by 3 publications

References 51 publications

Role of Brain Modulators in Neurodevelopment: Focus on Autism Spectrum Disorder and Associated Comorbidities

Role of Brain Modulators in Neurodevelopment: Focus on Autism Spectrum Disorder and Associated Comorbidities

Oxytocin, Vasopressin, and Sex Differences in Social Behavior. It’s Complicated!

The oxytocin system and early‐life experience‐dependent plastic changes

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