Pharmacological mechanisms of the water leaves extract of Lysiphyllum strychnifolium for its anti-inflammatory and anti-hyperuricemic actions for gout treatment

Sato, Vilasinee Hirunpanich; Chewchinda, Savita; Nuamnaichati, Narawat; Mangmool, Supachoke; Sungthong, Bunleu; Lertsatitthanakorn, Pilanthana; Ohta, Shinako; Sato, Hitoshi

doi:10.4103/pm.pm_14_18

Cited by 13 publications

(19 citation statements)

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“… 19 More recently, the anti-inflammatory and anti-hyperuricemic effects of the leaf water LS have been reported. 13 A clinical study likewise reported that water LS leaf could detoxify alcohol intoxication. 20…”

Section: Introductionmentioning

confidence: 99%

“…strychnifolium ) is classified as a family of Leguminosae . 13 Leaf decoction has been used to neutralize toxins in upper Northeastern Thailand. 14 Leaf, stem and root of L .…”

Section: Introductionmentioning

confidence: 99%

“…strychnifolium extracts (LS) were reported such as trilobatin, quercetin (QR), 3,5,6,3’,5pentahydroxyflavanonol3OαLrhamnopyranoside, 3,5,7trihydroxyc hromoone3OαLrhamnopyranoside, β-sitosterol, stigma sterol and gallic acid. 13 , 15 Preclinical studies have shown that LS (aqueous and ethanol) exhibited anti-HIV-1 integrase and anti-allergic activities with the most potent IC50 values of 11.2 and 6.4 μg/ml, respectively. 16 , 17 Moreover, different parts (stems/leaf) of LS (ethanol) have been shown to have medicinal properties.…”

Section: Introductionmentioning

confidence: 99%

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Antidote activity and protective effects of Lysiphyllum strychnifolium (Craib) A. Schmitz extract against organophosphate pesticide in omethoate-treated rats

Sukprasert

Deenonpoe

Yimsoo

et al. 2021

Journal of Traditional and Complementary Medicine

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Section: Introductionmentioning

confidence: 99%

“…strychnifolium ) is classified as a family of Leguminosae . 13 Leaf decoction has been used to neutralize toxins in upper Northeastern Thailand. 14 Leaf, stem and root of L .…”

Section: Introductionmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

See 1 more Smart Citation

Antidote activity and protective effects of Lysiphyllum strychnifolium (Craib) A. Schmitz extract against organophosphate pesticide in omethoate-treated rats

Sukprasert

Deenonpoe

Yimsoo

et al. 2021

Journal of Traditional and Complementary Medicine

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“…LS has been used in Northeast Thailand to promote lactation in breastfeeding women [3]. According to the literature review, LS leaves water extract contains quercetin [13], which is a phytoestrogen. Phytoestrogenic activity could trigger the herbal galactogogue effect and certain molecules may share comparable effects resembling E2 which is an endogenous estrogen enhancing reproduction of mammary epithelial cells [34].…”

Section: Discussionmentioning

confidence: 99%

The estrogenic effect of Lysiphyllum strychnifolium (Craib) A. Schmitz water extracts in MCF-7 cells

Maenpuen

Ekaratcharoenchai

Mongkolrob

et al. 2022

Preprint

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Background Lysiphyllum strychnifolium (Craib) A. Schmitz (LS) has been used to stimulate breast milk production in women after giving birth in the Northeast of Thailand. However, very little information is known about its estrogenic effect. The present study investigated the estrogenic effect of LS leaves water extracts compared with quercetin, one of the major compounds in LS, in MCF7 human breast cancer cells Methods The effect of LS leaves water extracts and quercetin on cell proliferation of estrogen receptor (ER)-positive breast cancer cells, MCF-7, was studied by MTT assay at a concentration range of 0 to 500 µg/ml. The expression of estrogen-dependent genes, the pS2, ERα, ERβ and Bcl-xL, were also examined by real time RT-PCR, and the expression of ERα protein was detected by Western blotting. Results The quercetin content in LS water extract was 285.67 ± 0.11 ug/g. The expression levels of the pS2 and Bcl-xL genes in MCF-7 cells were found to be upregulated by LS leaves water extract (20 µg/ml) and 17β-estradiol (E2) (10− 5 M) compared with the untreated control. The ERα gene expression was found to be upregulated by quercetin (0.16 µg/ml) and E2 (10− 5 M) compared with the untreated control. In addition, quercetin (0.16 µg/ml) and LS extract (0.8, 4, 20 µg/ml) decreased the phosphorylation of ERα at Ser167 (pERα (ser167)) and LS extract (20 µg/ml) decreased ERα, but there was no significant effect on the ERα at Ser118 (pERα (ser 118)) protein expression. Conclusions This study provided evidence for the potential estrogenic activities of LS leaves water extract. Since LS extract induced pS2 gene transcription, it was confirmed that the extract could affect the transcription of estrogen responsive genes causing estrogenic effects. The results also showed that quercetin, one of the LS compounds, upregulated ERα gene expression at 24-hour treatment.

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“…Hiperurisemia merupakan suatu kondisi berlebihnya kadar urat dalam darah yang disebabkan oleh terganggunya metabolism purin dan atau ekskresi asam urat (Sato et al, 2019). Asam urat adalah produk akhir metabolisme purin dalam tubuh manusia yang keluar dari tubuh melalui urin.…”

Section: Pendahuluanunclassified

Review: Aktivitas Antihiperurisemia Beberapa Tanaman dari Arboretum Garut

Yanti

Subarnas

Renggana

2021

JPS

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Hiperurisemia merupakan suatu kondisi berlebihnya kadar asam urat dalam darah. Hal ini dapat terjadi karena adanya kelebihan produksi asam urat dan kekurangan ekskresi asam urat, yaitu ditandai dengan kadar asam urat yang tinggi (> 7 mg/ dL). Jika hal tersebut terjadi secara terus-menerus maka akan terjadi gout arthritis. Di Arboretum Garut Terdapat banyak tanaman yang dapat digunakan sebagai antihiperurisemia seperti sirsak (Annona muricata L.), kayu manis (Cinnamomum burmanii), temu putih (Curcuma zedoaria), jamblang (Syzigium cumini), kersen (Muntingia calabura L.), pucuk merah (Syzigium myrrtifolium), dan salam (Syzigium polyanthum). Review jurnal ini membahas aktivitas antihiperurisemia beberapa tanaman yang berada di Arboretum Garut. Metode yang digunakan yaitu studi literatur beberapa jurnal yang didapat melalui situs google scholar, sciencedirect, Elsevier, dan sebagainya. Hasil yang didapat dari beberapa tanaman tersebut memiliki aktivitas antihiperurisemia dan tanaman yang memiliki persentase penurunan asam urat terbesar yaitu daun S. polyanthum dengan nilai persentase penurunan asam urat sebanyak 79,35%. Daun S. polyanthum memiliki potensi antihiperurisemia paling baik, sehingga perlu dikembangkan lebih banyak di Arboretum Garut. Kata Kunci: Arboretum, Asam Urat, Gout, Hiperurisemia, Tanaman Obat Hyperuricemia is a condition of excessive levels of uric acid in the blood. This can occur due to an overproduction of uric acid and a lack of uric acid excretion, which is characterized by high uric acid levels (> 7 mg / dL). If it happens continuously, gout arthritis will occur. In Garut Arboretum, there are many plants that can be used as antihyperuricemia such as soursop (Annona muricata L.), cinnamon (Cinnamomum burmanii), white turmeric (Curcuma zedoaria), java plum (Syzigium cumini), cotton candy berry (Muntingia calabura L.), pucuk merah (Syzigium myrrtifolium), and indian baywatch (Syzigium polyanthum). This journal review discusses the antihyperuricemia activity of several plants in Garut Arboretum. The method used is a literature study of several journals obtained from the google scholar site, sciencedirect, Elsevier, etc. The results show that several plants have antihyperuricemia activity and among those plants the S. polyanthum) have the highest reducing effect on blood uric acid with the reducing percentage of 79.35%. The leaves of S. polyanthum plant have the best potential for antihyperuricemia, so this plant is suggested to be developed in the Garut Arboretum.

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Pharmacological mechanisms of the water leaves extract of Lysiphyllum strychnifolium for its anti-inflammatory and anti-hyperuricemic actions for gout treatment

Cited by 13 publications

References 0 publications

Antidote activity and protective effects of Lysiphyllum strychnifolium (Craib) A. Schmitz extract against organophosphate pesticide in omethoate-treated rats

Antidote activity and protective effects of Lysiphyllum strychnifolium (Craib) A. Schmitz extract against organophosphate pesticide in omethoate-treated rats

The estrogenic effect of Lysiphyllum strychnifolium (Craib) A. Schmitz water extracts in MCF-7 cells

Review: Aktivitas Antihiperurisemia Beberapa Tanaman dari Arboretum Garut

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