Pharmacological mechanisms underlying the anti-ulcer activity of methanol extract and canthin-6-one of Simaba ferruginea A. St-Hil. in animal models

Abstract

The results obtained in this study with MESf and Cant added insights into the pharmacological mechanisms involved in their mode of antiulcer action. The results indicate that Cant is one of the compounds responsible for these effects. Such findings are of extreme importance in the strive for future development of potent, safer and effective antiulcer agent. The efficacy of MESf and Cant in gastroprotection shows that Simaba ferruginea might be a promising antiulcer herbal medicine, in addition to confirming the popular use of this plant against gastric ulcer models utilised in this study.

Protective efficacy of ursodeoxycholic acid nanoparticles in animal model of inflammatory bowel disease

“…Furthermore, consequently, there was a lesser accumulation of MPO in the colon tissue of the UNP-treated group of animals as observed from tissue biochemical analysis (Figure 8a), which can be corroborated by other studies (Clemente et al, 2012;Takagi et al, 2012). The UNPs reached the colon and maintained a constant level of drug in colon and delivered the total drug load that prevented ulcer formation showing the protective efficacy of UDCA (de Souza Almeida et al, 2011).…”

Effect and mechanism of evodiamine against ethanol-induced gastric ulcer in mice by suppressing Rho/NF-кB pathway

“…The gastric ulcer is characterized by the reduction in blood flow, infiltration of neutrophils, induction of oxidative stress and secretion of inflammatory cytokines [2,3]. Various factors including helicobacter pyloriinfection, alcohol consumption, smoking, excessive use of non-steroidal anti-inflammatory drugs (NSAIDs), psychological and physiological stress contribute to gastric ulcer [4].…”

α-Mangostin fromCratoxylum arborescens(Vahl) Blume Demonstrates Anti-Ulcerogenic Property: A Mechanistic Study

“…PUD occurs when the offensive factors overcome the defensive ones [1, 2]. There are many noxious agents that attack the stomach resulting in mucosal ulceration such as Helicobacter pylori infection, excessive ingestion of nonsteroidal anti-inflammatory drugs (NSAIDs), or alcohol as well as psychological stress and cigarette smoking.…”