Pharmacological modulation of the neural basis underlying inhibition of return (IOR) in the human 5-HT2A agonist and NMDA antagonist model of psychosis

Daumann, Jörg; Neukirch, A.; Thiel, Christiane M.; Möller-Hartmann, W.

doi:10.1007/s00213-008-1237-1

Cited by 42 publications

(52 citation statements)

References 69 publications

Supporting

Mentioning

Contrasting

Unclassified

Order By: Relevance

“…4 where the results have been combined across studies and doses to emphasize the similarities) agree in showing that the magnitude of measured IOR at 800 ms after the cue can be diminished under the influence of DMT and S-ketamine. Although blunted IOR was also found for S-ketamine by Gouzoulis-Mayfrank et al (2006), this was not replicated by Daumann et al (2008), though a trend toward significance was found. It is also the case that while facilitation is absent in the placebo condition there is about 10 ms of facilitation in both drug conditions.…”

Section: Hallucinogenic Modelscontrasting

confidence: 65%

“…Furthermore, while Hommel's (2008, 2009) work suggests that chronic cocaine use might eliminate the appearance of IOR, their findings, in combination with those of Fillmore et al's (2005), are consistent with the possibility that chronic cocaine use reduces the duration of IOR. Studies also suggest that hallucinogens may reduce the magnitude of IOR (Daumann et al 2008;GouzoulisMayfrank et al 2006), but this finding may reflect a deficit in endogenous engagement of attention. Future research with increased methodological rigor is required to clarify the acute effects of other psychoactive substances on IOR.…”

Section: Discussionmentioning

confidence: 93%

“…Catafau et al 1994;GouzoulisMayfrank et al 2002). As such, researchers have used hallucinogenic models as a complementary research strategy to investigate impairments in cognition, attention and behaviour in individuals with psychosis (Daumann et al 2008). Deficits in attention are common in schizophrenia (Lussier and Stip 2001) and researchers have investigated how spatial orienting of attention, in general, and IOR, in particular, manifest in psychosis (Daumann et al 2008); so far, results are inconsistent (e.g.…”

Section: Hallucinogenic Modelsmentioning

confidence: 98%

See 2 more Smart Citations

On the measurement of the effects of alcohol and illicit substances on inhibition of return

Olthuis

Klein

2012

Psychopharmacology

View full text Add to dashboard Cite

The importance of using multiple stimulus onset asynchronies, employing a cue-back to centre paradigm and distinguishing between acute and chronic substance use are emphasized. Furthermore, questions are raised as to whether findings suggest an impact of psychoactive substances on the subcortical mechanisms that play a critical role in the generation of IOR or are an indirect effect resulting from impairment of the cortical mechanisms responsible for voluntary disengagement of attention. Directions for future research and particular methodological approaches are highlighted.

show abstract

Section: Hallucinogenic Modelscontrasting

confidence: 65%

Section: Discussionmentioning

confidence: 93%

Section: Hallucinogenic Modelsmentioning

confidence: 98%

See 1 more Smart Citation

On the measurement of the effects of alcohol and illicit substances on inhibition of return

Olthuis

Klein

2012

Psychopharmacology

View full text Add to dashboard Cite

show abstract

“…Normal subjects are administered DMT and given various cognitive tasks to perform during fMRI scans. DMT slowed reaction time in tests of inhibition of return (Daumann et al, 2008; Gouzoulis-Mayfrank, et al, 2006), decreased alertness (Daumann et al, 2010), but produced less mismatch negativity than did the NMDA glutamate channel blocker ketamine (Heekeren et al, 2008), which commonly serves as a tool for investigating the glutaminergic hypothesis of schizophrenia.…”

Section: Dmt As a Model Of Psychiatric Disordersmentioning

confidence: 99%

Neuropharmacology of N,N-dimethyltryptamine

Carbonaro

Gatch

2016

Brain Research Bulletin

171

169

View full text Add to dashboard Cite

N,N-Dimethyltryptamine (DMT) is an indole alkaloid widely found in plants and animals. It is best known for producing brief and intense psychedelic effects when ingested. Increasing evidence suggests that endogenous DMT plays important roles for a number of processes in the periphery and central nervous system, and may act as a neurotransmitter. This paper reviews the current literature of both the recreational use of DMT and its potential roles as an endogenous neurotransmitter. Pharmacokinetics, mechanisms of action in the periphery and central nervous system, clinical uses and adverse effects are also reviewed. DMT appears to have limited neurotoxicity and other adverse effects except for intense cardiovascular effects when administered intravenously in large doses. Because of its role in nervous system signaling, DMT may be a useful experimental tool in exploring how brain works, and may also be a useful clinical tool for treatment of anxiety and psychosis.

show abstract

“…More specifically, early studies found that the preferential 5-HT 2A R agonist LSD impaired performance in the Stroop Test in healthy controls as well as in schizophrenia patients (Krus et al, 1963;Wapner and Krus, 1960). Recent evidence suggests that the 5-HT 2A/1A R agonist psilocybin and the 5-HT 2A/2C R agonist DMT disrupted a similar inhibitory mechanism of attention as measured with the inhibition-ofreturn (IOR) task, in which performance has been shown to be disturbed in schizophrenia (Daumann et al, 2008;Gouzoulis-Mayfrank et al, 2002, 2006a. Finally, cyproheptadineFan antagonist at 5-HT 2A/2B/2C , 5-HT 1A , and 5-HT 7 R with high affinity also for histamine and muscarinic receptors (PDSP: http://www.pdsp.med.unc.…”

Section: Introductionmentioning

confidence: 99%

Psilocybin-Induced Deficits in Automatic and Controlled Inhibition are Attenuated by Ketanserin in Healthy Human Volunteers

Quednow¹,

Kometer²,

Geyer

et al. 2011

Neuropsychopharmacol

187

120

View full text Add to dashboard Cite

The serotonin-2A receptor (5-HT(2A)R) has been implicated in the pathogenesis of schizophrenia and related inhibitory gating and behavioral inhibition deficits of schizophrenia patients. The hallucinogen psilocybin disrupts automatic forms of sensorimotor gating and response inhibition in humans, but it is unclear so far whether the 5-HT(2A)R or 5-HT(1A)R agonist properties of its bioactive metabolite psilocin account for these effects. Thus, we investigated whether psilocybin-induced deficits in automatic and controlled inhibition in healthy humans could be attenuated by the 5-HT(2A/2C)R antagonist ketanserin. A total of 16 healthy participants received placebo, ketanserin (40 mg p.o.), psilocybin (260 μg/kg p.o.), or psilocybin plus ketanserin in a double-blind, randomized, and counterbalanced order. Sensorimotor gating was measured by prepulse inhibition (PPI) of the acoustic startle response. The effects on psychopathological core dimensions and behavioral inhibition were assessed by the altered states of consciousness questionnaire (5D-ASC), and the Color-Word Stroop Test. Psilocybin decreased PPI at short lead intervals (30 ms), increased all 5D-ASC scores, and selectively increased errors in the interference condition of the Stroop Test. Stroop interference and Stroop effect of the response latencies were increased under psilocybin as well. Psilocybin-induced alterations were attenuated by ketanserin pretreatment, whereas ketanserin alone had no significant effects. These findings suggest that the disrupting effects of psilocybin on automatic and controlled inhibition processes are attributable to 5-HT(2A)R stimulation. Sensorimotor gating and attentional control deficits of schizophrenia patients might be due to changes within the 5-HT(2A)R system.

show abstract

Pharmacological modulation of the neural basis underlying inhibition of return (IOR) in the human 5-HT2A agonist and NMDA antagonist model of psychosis

Cited by 42 publications

References 69 publications

On the measurement of the effects of alcohol and illicit substances on inhibition of return

On the measurement of the effects of alcohol and illicit substances on inhibition of return

Neuropharmacology of N,N-dimethyltryptamine

Psilocybin-Induced Deficits in Automatic and Controlled Inhibition are Attenuated by Ketanserin in Healthy Human Volunteers

Contact Info

Product

Resources

About