Pharmacological prevention of diabetic cataract

Kyseľová, Zuzana; Štefek, Milan; Bauer, V.

doi:10.1016/s1056-8727(03)00009-6

Cited by 176 publications

(151 citation statements)

References 128 publications

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“…in senile cataract and diabetic cataract the oxidative stress may be systemic and related not only to the lens (24,41) Multiple mechanisms have been proposed in the development of diabetic cataract: nonenzymatic glycation of the eye lens proteins, oxidative stress, and activated polyol pathway in glucose disposition. An increased amount of glucose is converted into sorbitol by the enzyme aldoz reductase via the polyol pathway (28,43). in diabetic patients, accumulation of sorbitol in a lens presumably raises the osmotic pressure and increases the water volume in the lens enough to cause its swelling and rupturing of the len's fibers.…”

Section: Resultsmentioning

confidence: 99%

“…in diabetic conditions, RoS are produced via glucose autoxidation and also via non-enzymatic protein glycation in various tissues. RoS is considered to have an important role in the development of microvascular complications in patients with diabetes (2,3,25,28,30). Free sulfydryl (-Sh) groups of proteins are mainly responsible for their antioxidant response, and they can serve as a sensitive indicator of oxidative stress (36,37).…”

Section: Introductionmentioning

confidence: 99%

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Oxidant/Antioxidant Status of Patients with Diabetic and Senile Cataract

Aksoy

Gürler

Aksoy³

et al. 2010

Biotechnology & Biotechnological Equipment

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Section: Resultsmentioning

confidence: 99%

Section: Introductionmentioning

confidence: 99%

Oxidant/Antioxidant Status of Patients with Diabetic and Senile Cataract

Aksoy

Gürler

Aksoy³

et al. 2010

Biotechnology & Biotechnological Equipment

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“…DM increases oxidative stress in tissues, which in turn plays a role in the pathogenesis of various diabetic complications such as cataract (25,26) . Reactive oxygen species promote a series of cellular responses that result in abnormal cellular functions.…”

Section: Discussionmentioning

confidence: 99%

Oxidative stress of crystalline lens in rat menopausal model

Acer¹,

Pekel²,

Küçükatay³

et al. 2016

Arquivos Brasileiros De Oftalmologia

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Purpose: To evaluate lenticular oxidative stress in rat menopausal models. Methods: Forty Wistar female albino rats were included in this study. A total of thirty rats underwent oophorectomy to generate a menopausal model. Ten rats that did not undergo oophorectomy formed the control group (Group 1). From the rats that underwent oophorectomy, 10 formed the menopause control group (Group 2), 10 were administered a daily injection of methylprednisolone until the end of the study (Group 3), and the remaining 10 rats were administered intraperitoneal streptozocin to induce diabetes mellitus (Group 4). Total oxidant status (TOS), total antioxidant capacity (TAC), and oxidative stress index (OSI) measurements of the crystalline lenses were analyzed. Results: The mean OSI was the lowest in group 1 and highest in group 4. Nevertheless, the difference between the groups was not statistically significant in terms of OSI (p>0.05). The mean TOS values were similar between the groups (p>0.05), whereas the mean TAC of group 1 was significantly higher than that of the other groups (p<0.001). Conclusions:Our results indicate that menopause may not promote cataract formation.

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“…Under hyperglycemic conditions, proteins undergo glycation (Kyselova et al, 2004;Patel, 2012). Ocular tissues however contain antioxidants (enzymatic and non-enzymatic) that prevent oxidative damages (Kisic et al, 2012) but when these barriers are broken, cataract develops.…”

Section: Introductionmentioning

confidence: 99%

“…Even drugs that were developed to delay or prevent opacification have failed to give convincing results when tested (Marsili et al, 2004). Although cataract surgery is highly effective, the limited number of surgeons especially in developing countries is a major limitation (Kyselova et al, 2004).…”

Section: Introductionmentioning

confidence: 99%

Evaluation of the effect of <i>Spathodea campanulata</i> flower bud exudate on cataractogenesis in rat lenses

Gbemisola¹,

Faluyi²,

Osoniyi³

2015

Afr. J. Trad. Compl. Alt. Med.

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Background: The flower bud exudates of Spathodea campanulata is commonly used as a local eye drop in Nigeria and is anecdotally claimed to improve vision. This study evaluated the anti-cataract activity of Spathodea campanulata (SPCM) flower bud exudates against cataractogenesis using rat lenses. This was done with a view to providing empirical scientific support for the use of the exudates from SPCM in the treatment and management of certain eye disorders. Materials and Methods: Fifty (50) rat lenses were used in this study, i.e. five groups of ten (10) lenses per group. Lenses were incubated in artificial aqueous humor (Normal control) with simultaneous incubation in 30 mM galactose (Untreated cataract). Co-incubation with captopril (Captopril treated cataract); 0.1 mg/ml of the exudate (Exudate treated cataract -Low dose) and 0.2 mg/ml of exudate (Exudate treated cataract-High dose) constituted the study groups. After 72 hr of incubation, lenses were observed for cataract and the preventive potential of the exudate against cataractogenesis was evaluated through the determination of the levels of anti-oxidant parameters such as total protein (TP), glutathione (GSH), malondialdehyde (MDA) and activities of superoxide dismutase (SOD) and catalase (CAT) were evaluated in the lens homogenates. Results: Photographic evaluation of the lenses showed the development of cataract in the untreated cataract group while opacification was retarded in higher dose exudate-treated and captopril treated lenses. Significant decrease in the levels of GSH and total protein, reduction in SOD and CAT activities as well as increase in MDA content were observed in cataractous lenses when compared with the normal control. SPCM displayed a doserelated anti-cataract activity. Captopril showed comparable anti-cataract potential to (0.2 mg/ml) SPCM. GSH, SOD and CAT activity in captopril treated cataract lenses increased to 75.55%, 64.08% and 72.45% of the normal control values respectively. In (0.2 mg/ml) exudate treated cataract lenses; GSH, SOD and CAT activity increased to 57.7%, 76.69% and 80.61% respectively. Conclusion:The study concluded that exudate of SPCM elicited its anti-cataract potential through its anti-oxidant activities.

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Pharmacological prevention of diabetic cataract

Cited by 176 publications

References 128 publications

Oxidant/Antioxidant Status of Patients with Diabetic and Senile Cataract

Oxidant/Antioxidant Status of Patients with Diabetic and Senile Cataract

Oxidative stress of crystalline lens in rat menopausal model

Evaluation of the effect of <i>Spathodea campanulata</i> flower bud exudate on cataractogenesis in rat lenses

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