Pharmacological Properties and Chemical Constituents of Murraya paniculata (L.) Jack

Abstract

Chemical Constituents of Murraya paniculata (L.) Jack M. paniculata has been investigated for its bioactive compounds by many research groups. To date, various compounds were identified, ranging from indole alkaloids, coumarins, phenols, terpenoids to flavonoids. Besides, 60 compounds have been identified from volatile and essential oil extracted from M. paniculata leaves. The chemical components from different parts of M. paniculata were identified using chromatographic techniques and the structures were elucidated using spectroscopic techniques. A number of these compounds exhibited significant biological activities, which serve as the scientific evidence for the traditional usage of M. paniculata. In 1986, an anti-implantation alkaloid, called Yuehcukene, 1β-(3,indolyl-7,9α,9β-trimethyl-5β,8,9,10β-tetrahydroindano-[2,3-b] indole was also isolated from M. paniculata leaves [14]. Moreover, the two indole alkaloids, murrayacarine [15] and murrayaculatine [16] were isolated from root bark and flowers of M. paniculata respectively. In early 1980s, different research groups isolated 3' ,4' ,5,5' ,7,8-hexamethoxyflavone (Figure 2a) and 3,3' , 4' ,5,5' ,7,8-heptamethoxyflavone (Figure 2b) from the methanolic extract of M. paniculata leaves [17,18]. Later, a flavone named 3,5,7,3' ,4' ,5'-hexamethoxyflavone, was isolated from M. paniculata flower [16]. Other research groups isolated eight flavonoids from M. paniculata leaves [12,19] and ten flavonoids from the peel and pulp of the fruits of the plant [20].

Influence of Extraction on the Yield, Phytochemical and LCMS Profile from Standardized Kemuning Leaf (Murraya paniculata (L.) Jack)

“…5 There are many reports on pharmacological effects of the plant including antinociceptive, antioxidant and anti-diabetic, to antimicrobial and analgesic activities. 7,8 Kemuning also showed the decrease in triglyceride, total and LDL cholesterol levels on rats. 3 Kemuning leaves (Murraya paniculata (L.) Jack) contain chemical compounds which are secondary metabolites such as essential oils, indole alkaloids, flavonoids, saponins, coumarins, and tannins.…”

“…6 Murraya paniculata (L.) Jack, commonly known as Orange Jessamine, is a tropical, evergreen plant with tiny, white, scented flowers, which is cultivated as an ornamental tree or hedge. 7 This plant is a small shrub, tropical, green, flowering small, white, and flavorful. M. paniculata often grows in southern China (Hainan, Guangdong, Fujian, and Guangxi), India, Thailand, Malaysia, and Australia.…”

Ethnobotany, Phytochemical, Pharmacological Potentials of Murraya koenigii, and Its Health Benefits – A Review

“…In the chromatographic studies of petroleum ether extract of seeds, koenimbine, girinimbine, mahanimbine, mahanine, isomahanine [25] and 2-methoxy-3-methyl carbazole. Structural confirmation of bioactive carbazole alkaloids like koenimbine, koenine, kurryam were obtained by 2D NMR spectra [26].…”

PRODUKSI FLAVONOID DAUN KEMUNING (Murraya paniculata L. Jack) PADA DOSIS PUPUK ORGANIK DAN INTERVAL PANEN YANG BERBEDA

“…Hal ini memungkinkan ada senyawa lain dari kelompok fenolik yang memiliki sifat antioksidan kuat selain flavonoid. Menurut Sayar et al (2014) senyawa golongan flavonoid yang dominan pada daun kemuning tergolong senyawa flavon.…”