Pharmacological properties of pyridinium salts, pyrazolines, and pyrazoles

Zvezdina, É. A.; Zhdanova, M. P.; Nechayuk, I. I.; Barchan, I. A.; Simkina, Yu. N.; Buchnaya, T. A.

doi:10.1007/bf00763700

Cited by 3 publications

(3 citation statements)

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“…Inactive N-phenyl-4,6-diphenyl-2-picolinium iodide used as the reference and support was synthesized by reported methods [22][23][24][25] from the corresponding pyrillium salts, mp 243-244°C (mp 243-245°C [43]). …”

Section: Methodsmentioning

confidence: 99%

“…We should note that this reaction can be carried out only for collidine derivatives [24]. For disubstituted pyridines, this reaction is possible only when the molecule has phenyl substituents in the heterocyclic ring [25]. The study of the biological processes and mechanism of gene therapy requires the use of fine instruments and, hence, the labeled atom method is extremely promising [26][27][28][29][30].…”

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confidence: 99%

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New method for the synthesis of difficultly available sterically hindered tritium-labeled pyridinium derivatives

Щепина

Аврорин

Badun

et al. 2010

Chem Heterocycl Comp

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Section: Methodsmentioning

confidence: 99%

mentioning

confidence: 99%

New method for the synthesis of difficultly available sterically hindered tritium-labeled pyridinium derivatives

Щепина

Аврорин

Badun

et al. 2010

Chem Heterocycl Comp

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“…Many pyrazolo[1,5- c ]pyrimidines are known to possess significant hypnotic, tranquilizing, fungicidal, insecticidal and antibacterial activities [1,2,3]. Also, the coordination of pyrazolo[1,5- c ]pyrimidines to transition metal ions such as Cu +2 and Ni +2 enhances their biological activities [4,5,6,7].…”

Section: Introductionmentioning

confidence: 99%

Synthesis and Electrophilic Substitutions of Novel Pyrazolo[1,5-c]-1,2,4-triazolo[4,3-a]pyrimidines

Atta

2011

Molecules

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5-Aryl-7-hydrazino-2-phenylpyrazolo[1,5-c]pyrimidines 1 were used as precursors for the preparation of a new series of 5-aryl-8-phenylpyrazolo[1,5-c]-1,2,4- triazolo[4,3-a]pyrimidines 2. The reactions of 2 with certain electrophilic reagents gave the respective 6-substituted derivatives 3-5 rather than the 7-isomeric products. Formylation of the key compounds 1 with ethyl formate yielded the formyl derivatives 6. Furthermore, boiling of compounds 1 with acetic acid afforded 7-acetylhydrazino-5-aryl-2-phenylpyrazolo[1,5-c]pyrimidines 7. Bromination of 7 yielded the dibromo- derivatives 8, while their iodination and nitration gave the monosubstituted derivatives 9 and 10, respectively. Also, treatment of 1 with boiling acetic anhydride yielded the triacetyl derivatives 11. The structure of synthesized products was confirmed by elemental analyses, IR, 1H NMR and MS spectra.

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