Pharmacological Proprieties of the Ethanol Extract of Muehlenbeckia platyclada (F. Muell.) Meisn. Leaves

Abstract

Antinociceptive and anti-inflammatory activities of the Muehlenbeckia platyclada leaves’ ethanol extract were investigated in animal models. The extract (p.o.) reduced the number of abdominal contortions induced by acetic acid by 21.57% (400 mg/kg). After intraplantar injection of formalin, a dose of 400 mg/kg (p.o.) inhibited the time spent paw licking in the first phase (26.43%), while the second phase was inhibited by 10.90 and 36.65% at the doses of 200 and 400 mg/kg, respectively. The extract (p.o.) increased the reaction time on a hot plate at a dose of 400 mg/kg (32.68 and 40.30%) after 60 and 90 minutes of treatment, respectively. The paw edema was reduced by extract (p.o.) at doses of 100 (15.46 and 16.67%), 200 (22.68 and 25.64%) and 400 mg/kg (29.50 and 37.33%) after 3 to 4 h of carrageenan application, respectively. Doses of 100, 200 and 400 mg/kg (p.o.), administered 4 h after the carrageenan injection, reduced the exudate volume (11.28, 21.54 and 45.13%), while leukocyte migration was reduced by 21.21 and 29.70% at the doses of 200 and 400 mg/kg, respectively. These results indicate that the ethanol extract from M. platyclada may constitute a potential target for the discovery of new molecules with antinociceptive and anti-inflammatory activities that can be explored for their therapeutic use.

Antinociceptive and Anti-Inflammatory Effects of Octacosanol from the Leaves of Sabicea grisea var. grisea in Mice

“…Five minutes after the acetic acid injection, the number of times that each animal presented abdominal constriction was counted for 10 consecutive min. The percentage of inhibition was determined for each experimental group using the following formula [ 14 ]:…”

Chemical Constituents of Muehlenbeckia tamnifolia (Kunth) Meisn (Polygonaceae) and Its In Vitro α-Amilase and α-Glucosidase Inhibitory Activities

“…Glycosylated flavonoids such as catechin and quercitrin, isolated from M. platyclada , have shown antinociceptive and anti-inflammatory activities. A series of anthraquinones such as emodin, physcion and emodin-8-β- d -idopyranoside, isolated from the leaves of M. hastulata , showed promising antioxidant activity measured by the DPPH method [12,13].…”

Muehlenbeckia volcanica (Benth.) Endl.: Revisión de una Polygonaceae peruana de interés científico

“…Bussmann Figura 3. Componentes activos aislados del género Muelhenbeckia Esta familia es rica en taninos(Brandbyge 1993), y en plantas pertenecientes al género Muehlenbeckia como M. hastulata, M. platyclada y M. volcanica se ha determinado que contienen este tipo de compuestos(Tamariz-Angeles et al 2018;Mellado et al 2012;Fagundes et al 2010), encontrando en M. hastulata 1,03 mg ácido tánico/100 g de hojas por el método de Lowenthal(Rosso 2018;Colina Ramos 2016). Las catequinas y las leucoantocianinas son los componentes más comunes en esta familia, pero también se producen taninos hidrolizables.…”