Pharmacological research on natural substances in Latvia: Focus on lunasin, betulin, polyprenol and phlorizin

Muceniece, Ruta; Namniece, Jana; Nakurte, Ilva; Jēkabsons, Kaspars; Riekstiņa, Una; Jansone, Baiba

doi:10.1016/j.phrs.2016.03.040

Cited by 18 publications

(9 citation statements)

References 91 publications

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“…In our study, we focused on the characterization of Abies sibirica L. derived polyprenols with prevalent isoprenoid alcohol chain lengths of C 55 -C 100 (isoprene unit count [11][12][13][14][15][16][17][18][19][20], which correspond to the general description of conifer polyprenol extracts [7,41]. The main intent was to develop a commercially viable polyprenol delivery system that could be used for food supplement and cosmetic applications.…”

Section: Discussionmentioning

confidence: 99%

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Identification of Abies sibirica L. Polyprenols and Characterisation of Polyprenol-Containing Liposomes

et al. 2020

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The needles of conifer trees are one of the richest sources of natural polyprenols. Polyprenol homologs from Abies sibirica L. lipophilic 80% purified extract were analyzed and quantified. In total, 10 peaks (Prenol-11 to Prenol-20) were observed in the ultra-high-performance liquid chromatography–diode array detector (UHPLC-DAD) chromatogram of Siberian fir with the most abundant compound being Prenol-15 (relative amount 37.23 + 0.56% of the total polyprenol yield). Abies sibirica L. polyprenol solubility and incorporation efficiency into liposomes were studied in various commercially available lecithin mixtures (Phosal IP40, Phosal 75SA, and Lipoid P45). The resulting multilamellar polyprenol liposomes were morphologically characterized by Light and Transmission Electron Microscopy, and the liposome size was discovered to be polymodal with the main peak at 1360 nm (90% of the volume). As polyprenols are fully soluble only in lipids, a liposomal formulation based upon co-solubilization and a modified ethanol injection method of polyprenols into the ethanol-phospholipid system was developed for the entrapment and delivery of polyprenols for potential commercial applications in food supplement and cosmetic industries.

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Section: Discussionmentioning

confidence: 99%

“…As free substances, polyprenols have limited bioavailability due to high hydrophobicity and limited emulsification in the digestive tract [16]. Due to these limitations of polyprenols, a liposome is an accommodating form of polyprenol delivery.…”

Section: Introductionmentioning

confidence: 99%

Identification of Abies sibirica L. Polyprenols and Characterisation of Polyprenol-Containing Liposomes

et al. 2020

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“…The dihydrochalcone phlorizin is a natural product and dietary constituent found in a number of fruit trees. Phlorizin plays an important role in the mechanistic research of glucose reabsorption and hyperglycemia (Muceniece et al, ). The alternation of trehalose and glycogen in the hemolymph and fat body showed that the glucose in the hemolymph probably came from the hydrolyzation of trehalose but not glycogen.…”

Section: Discussionmentioning

confidence: 99%

“…In this paper, we chose phlorizin, santonin, and amygdalin as study objects; the three β‐glucosides have been used as antidiabetic drugs (Muceniece et al, ) and in anthelmintic and anticancer therapy (Jaswal, Palanivelu, & Ramalingam, ), respectively. The effects of the three toxic plant β‐glucosides, phlorizin, santonin, and amygdalin, were evaluated on the carbohydrate metabolism in the larvae of the cotton bollworm, Helicoverpa armigera .…”

Section: Introductionmentioning

confidence: 99%

Effects of toxic β‐glucosides on carbohydrate metabolism in cotton bollworm, Helicoverpa armigera (Hübner)

Lin

et al. 2019

Arch Insect Biochem Physiol

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The purpose of this study was to evaluate the effects of three toxic β-glucosides, phlorizin, santonin, and amygdalin, on carbohydrate metabolism in the cotton bollworm, Helicoverpa armigera (Hübner), when diets mixed with β-glucosides were fed to third-instar larvae. The growth of the larvae was significantly inhibited by exposure to santonin after 96 hr but not obviously affected by phlorizin and amygdalin. The midgut trehalase activities were only 51.7%, 32%, and 42.5% of that of the control after treatment with phlorizin, santonin and amygdalin at 2 mg/ml, respectively. In the hemolymph and fat body, the amount of trehalose decreased in all cases. However, the effects of santonin on the alteration of the glycogen and glucose levels as well as the activities of glycogen phosphorylase, were different than those of the other two β-glucosides. It appears that the three β-glucosides have different influences on the carbohydrate metabolism of cotton bollworm. K E Y W O R D Scarbohydrate metabolism, cotton bollworm, trehalase, β-glucosides

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“…Lunasin is a 43 amino acid-long peptide present in soybean, and consists of several arginine-glycine-aspartic acid (RGD) residues and a carboxylic acid tail of nine aspartic acid residues [25]. Lunasin exhibits various beneficial effects on human health including inhibitory effects against DMBA and TPA (12-O-tetradecanoylphorbol-13-acetate)-induced skin cancer and skin inflammation through the deacetylation of histones and inhibition of acetylation [26].…”

Section: Soybean Peptidesmentioning

confidence: 99%

Review of Soybean Phytochemicals and Their Bioactive Properties Relevant for Skin Health

Kim¹,

Kang²,

Park³

et al. 2017

JFNR

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Numerous studies have investigated the bioactive properties of compounds present in soybean (Glycine max) that may have beneficial effects on the health of human skin. Several such compounds have already been introduced into commercial cosmetic products to promote functional properties such as skin whitening, anti-wrinkle activity and skin hydration. However, a significantly greater understanding of the application of soybean ingredients in these types of products is needed before optimal benefits can be realized. In this review, we aim to summarize some of the biological properties of soybean constituents and the underlying mechanisms of action responsible for beneficial effects in skin. In addition, we will discuss future directions for studies that may help to expand the applications for soybean compounds.

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Pharmacological research on natural substances in Latvia: Focus on lunasin, betulin, polyprenol and phlorizin

Cited by 18 publications

References 91 publications

Identification of Abies sibirica L. Polyprenols and Characterisation of Polyprenol-Containing Liposomes

Identification of Abies sibirica L. Polyprenols and Characterisation of Polyprenol-Containing Liposomes

Effects of toxic β‐glucosides on carbohydrate metabolism in cotton bollworm, Helicoverpa armigera (Hübner)

Review of Soybean Phytochemicals and Their Bioactive Properties Relevant for Skin Health

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