Pharmacological screening and acute toxicity of bark roots of Guettarda platypoda

Abstract

Due to its folk use, scientifi c reports and phytochemical screening, the purpose of this work was to study the phytochemical and the biological properties of the methanol extract and to evaluate the anti-infl ammatory activity as well as determine the acute toxicity, antitumor and cytotoxic activity of the root barks of Guettarda platypoda DC., Rubiaceae. In this analysis the presence of fl avonoids and therpenoids were identifi ed. These data and the ones in the literature indicated it as a potential antioxidant and motivated the cytotoxic analysis related with three tumoral cell strains as well as to evaluate its antitumoral activity (sarcoma 180 and Ehrlich carcinoma) in female mice. Due to the presence of esteroids and the previous study of the ethanolic extract, its anti-infl ammatory activity and toxicity were also evaluated. Absence or low toxicity in 2000 mg/kg doses was verifi ed and the attention to their phytochemical and pharmacological properties is constantly increasing.

Development of an insecticidal nanoemulsion with Manilkara subsericea (Sapotaceae) extract

“…Treatment with HFNE was performed at a single high dose corresponding to 3 g/kg of extract per animal. Since no death or toxic signals were observed, LD50 could not be estimated and HFNE, suggesting that HFNE may be considered non-toxic [ 30 ].…”

“…Acute toxicity studies were performed using both sexes of mice according to Pina et al (2012) [ 30 ], with some modifications. Treated groups received a single dose of HFNE (5% of MOD®, 5% of surfactants (HLB of 10.75), 5% of hexane-soluble fraction from fruits of M. subsericea and 85% of water) by oral route, corresponding to 3 g/kg of extract.…”

Anti-Amyloidogenic and Cyclooxygenase Inhibitory Activity of Guettarda speciosa

“…In this experiment, these compounds were defined as indole alkaloids ( 1 , 5 ), iridoids ( 2 , 3 ), steroid ( 4 ), triterpenoids ( 7 , 9 ), and polyhydroxy cyclic acids ( 6 , 8 ). Pharmacological studies on G. platypoda have reported the synergistic action of quinic acid glycosides with β-sitosterol and triterpenes with anti-inflammatory activity, while the mechanism of β-sitosterol is comparable to hydrocortisone [32]. Most of the Rubiaceae species also contained iridoids and indole alkaloids [40], which are known to possess anti-inflammatory activities [41,42].…”

Purification and MIC analysis of antimicrobial proteins from Cucumis sativus L. seeds

“…Cucumis sativus L (generic name cucumber), from the family Cucurbitaceae, is an important restorative plant with different pharmacological benefits, generally utilized in traditional drug therapies such as Unani, Ayurveda, Siddha, Traditional Chinese. Previous studies done on the plant demonstrated that the plant has numerous essential phytoconstituents like glycosides, flavones, terpinoids, phytosterol, saponins and anolignan B, tannins, ellargic corrosive, glucose, fructose [ 10 ]. These mixes were observed to be involved in a number of the pharmacological exercises, for example, antibacterial, antifungal, antidiabetic, cytotoxic, antacid and carminative movement, hepatoprotective action, and wound healing activities.…”