Pharmacological Screening of Anti Diabetic Activity of Polyherbal Formulation In Wistar Albino Rats

Abstract

The aim of the present research is anti diabetic activity of polyherbal formulation comparing with individual plant extractions. The anti diabetic activity of a polyherbal formulation was evaluated in using Alloxan βcytotoxin induced chemical diabetes in a wide variety of wister rats. Methanolic extract of the poly herbal formulation, prepared from powder of plants Fruits of Momordica charantia, stem and root of Tinospora cordifolia , aerial parts of Andrographis peniculeta and wood of Pterocarpus marsupium and leaves of Gymnema sylvestre was subjected to phytochemical test and pharmacological screening of Anti diabetic activity at a dose level 400mg/kg. The PHME (400mg/kg) treated diabetic rats show mean (±SEM) fasting serum glucose of 253.11±3.41mg/dl on day 0 which was reduced to 161.43±3.55mg/dl on day 7, 107.45±4.52mg/dl on day 14 . These changes in fasting serum glucose illustrate that the diabetic rats treated with PHME (400mg/kg) show a progressive and significant (p≤0.05) reduction in fasting serum glucose during the treatment period in comparison to diabetic group of rats. It was concluded that individual extraction shows the activities but in combination of plants it shows synergistic effect so poly herbal extraction is useful more when compared with given in individual plants.