The present study was aimed to evaluate the nephroprotective activity of ethanolic extract of Carissa carandas Linn. Leaves (EECC) in Gentamicin-induced nephrotoxicity in Wistar albino rats. The renal damage was induced by Gentamicin (80mg/kg body weight, i.p.). Nephroprotective activity was investigated by the administration of EECC at two different doses (100 and 200mg/kg body weight, p.o) for 28 days and by assessing serum parameters, renal oxidative stress markers and histopathological studies. Gentamicin-treated animals showed an increase in serum creatinine, uric acid, urea, and malondialdehyde (MDA) levels and decrease in total protein, reduced glutathione (GSH), and catalase(CAT) compared to normal control animals, which indicates severe nephrotoxicity. Histopathological studies of kidney Gentamicin-treated animals showed extensive acute tubular necrosis and peri-tubular inflammation. Administration of EECC showed a significant improvement (p<0.05) in biochemical and oxidative stress markers compared to the disease group. EECC treated groups showed better histological appearance when compared to the disease group. Ethanolic extract of Carissa carandas Linn. Leaves showed significant nephroprotective activity against gentamicin-induced acute kidney injury.

The aim of the present research is anti diabetic activity of polyherbal formulation comparing with individual plant extractions. The anti diabetic activity of a polyherbal formulation was evaluated in using Alloxan βcytotoxin induced chemical diabetes in a wide variety of wister rats. Methanolic extract of the poly herbal formulation, prepared from powder of plants Fruits of Momordica charantia, stem and root of Tinospora cordifolia , aerial parts of Andrographis peniculeta and wood of Pterocarpus marsupium and leaves of Gymnema sylvestre was subjected to phytochemical test and pharmacological screening of Anti diabetic activity at a dose level 400mg/kg. The PHME (400mg/kg) treated diabetic rats show mean (±SEM) fasting serum glucose of 253.11±3.41mg/dl on day 0 which was reduced to 161.43±3.55mg/dl on day 7, 107.45±4.52mg/dl on day 14 . These changes in fasting serum glucose illustrate that the diabetic rats treated with PHME (400mg/kg) show a progressive and significant (p≤0.05) reduction in fasting serum glucose during the treatment period in comparison to diabetic group of rats. It was concluded that individual extraction shows the activities but in combination of plants it shows synergistic effect so poly herbal extraction is useful more when compared with given in individual plants.

The analgesic and anti-inflammatory activity of the poly herbal formulation (composed of the extracts from Terminalia chebula, tinospora cordifolia, Phyllanthus emblica, Portulaca oleracea) was evaluated in Acetic Acid Induced Writhing Method, Eddy's Hot Plate Method: (Thermal stimulus), Carrageenan induced hind paw edema. The extract at dose of 200, 400 mg/kg produced significant inhibition of oedema and pain induced by above mentioned methods. The result obtained suggesting that extract possesses significant analgesic and anti-inflammatory activity.

The present study aimed that evaluation of anti hyperlipidemic activity of Momordica charantia, stem and root of Tinospora cordifolia, whole plant of Andrographis paniculata and wood of Pterocarpus marsupium and leaves of Gymnema sylvestre by Maceruation method. Individually and combined both plants extracted poly herbal extraction and screened for phytochemical study and Anti-Hyperlidemic activity by Triton X 100 Induced Hyperlipidemia model, High Fat Diet (FD) induced hyperlipidemic model, Estimation of Serum total cholesterol (TC) CHOD- PAP, Estimation of serum triglycerides, Estimation of HDL-cholesterol, Estimation of LDL cholesterol, Phytochemical investigation reveals the presence of alkaloids, flavonoids, saponins, tannins, steroids, triterpinoids, carbohydrates and glycosides in poly herbal methanolic extraction and individual plant extraction, In acute toxicity studies no mortality was observed with either of the extracts even at the dose level of 2000 mg/kg body weight In the present study, the methanol extracts of three plants reduced the cholesterol and triglycerides in a manner similar to the reduction facilitated by atorvastatin. The hypolipidemic activities of atorvastatin and the methanol extract of individual and polyherbal extraction were evident in both synthesis and excretory phases of triton-induced hyperlipidemia in rats.

Introduction: Coronavirus belongs to the family coronaviridae that majorly affects the respiratory system this group of virus outbreak previously as SARS and MERS in various countries and recently as COVID-19. COVID-19 has symptoms like fever, dry cough, breathing problems, loss of smell and taste, body aches. COVID-19 has spread to 210 countries and infected 272.51 million people worldwide, reached over 5.34 million deaths. Treatment includes antivirals, antibiotics, Non Steroidal Anti-Inflammatory Drugs, corticosteroids. Methodology: It is a hospital-based retro-prospective study was conducted for 6 months in the Inpatient department. 100 patients were taken who met the inclusion criteria. Data collected and evaluated, analyzed by open label study. Results and Discussion: severe COVID-19 can develop systemic inflammatory responses that can lead to lung injury and multisystem organ dysfunction. It has been proposed that the potent anti-inflammatory effects of corticosteroids might prevent or mitigate these deleterious effects. Both beneficial and deleterious clinical outcomes have been reported with the use of corticosteroids in patients with other pulmonary infections From study, The Recovery% using steroids in the time period of 0-10 and 11-20 days was found to be 34 and 27% respectively. The Recovery percentage using steroids in the time period of 0-10 and 11-20 days was found to be 18 and 8% respectively. Dexamethasone was most commonly used in males and females, 77.08 and 84% respectively. Conclusion: Considering beneficial effects of corticosteroids in COVID -19, prescribing steroids is safe by dose tapering continued up to 10days or hospital discharge