Pharmacological screening of Nigerian species of Musanga cecropioides R. Br ex Teddlie (Moraceae) in rodents as anti-hypertensive

Senjobi, C.T.

doi:10.5897/ajps11.007

Cited by 4 publications

(4 citation statements)

References 3 publications

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“…The mechanism of action of alkaloids such as harmane and berberine is linked to this property. [4] The chemical evaluation of medicinal plants and their isolates is of global research interest due to the increasing microbial resistance to conventional antibiotics. With each passing decade, the incidence of multi drug-resistant bacteria keeps rising, thus, leading toan increase in morbidity, mortality, and cost of health care.…”

Section: Annals Of Health Research Volume 6 Issue No 1 2020__________...mentioning

confidence: 99%

Qualitative phytochemical screening and antimicrobial evaluation of the total alkaloids of the hydroalcoholic extracts of the leaves and stem bark of Musanga cercropoides (Urticaceae)

Ibitoye¹,

Ukpo²,

Rabiu³

2020

Ann Health Res

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Background: Musanga cecropioides R.Br. ex Tedlie (Urticaceae) is a plant that is widely used in Nigerian traditional medicine for the treatment of various infections such as cough, diarrhoea, and vaginal candidiasis. Objective: To study the antimicrobial potency of the total alkaloids of the hydroalcoholic extracts (HAE) of the stem bark (ST) and leaves of Musanga cecropioides. Method: The antimicrobial activities of the total alkaloidal constituent of the HAE of the ST and leaves were screened using agar diffusion method using Staphylococcus aureus, Bacillus subtils,Klebsiella pneumonia, Escherichia coli, and Candida albicans as test organisms. The preliminary phytochemical screening of the ST and leaves were performed following the conventional standard procedures of Trease and Evans. Results: Phytochemical screening revealed the presence of alkaloids, phenols, flavonoids, tannins, sterols, saponins and terpenoids. The HAE of both ST and leaves exhibited notable activities against the tested microorganisms at different concentrations (500, 250, 125, 62.5 mg/ml) with zones of inhibition ranging from 8.6±0.5mm to 20.0±1.0mm. The highest activity against bacteria had a zone of inhibition of 18.6±1.1mm and 20.0±1.0mm for fungus. The zone of inhibition for antibacterial control drug (Ciprofloxacin) was 42.3±2.0mm while that of antifungal control drug (Griseofulvin) was 32.0±0.8mm. The total alkaloid yield for the ST was 1.200%w/w and 1.332%w/w for the leaves. Conclusion: Musanga cercropoidesmay be a valuable source of a therapeutic agent for potent clinical antimicrobials.

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Section: Annals Of Health Research Volume 6 Issue No 1 2020__________...mentioning

confidence: 99%

Qualitative phytochemical screening and antimicrobial evaluation of the total alkaloids of the hydroalcoholic extracts of the leaves and stem bark of Musanga cercropoides (Urticaceae)

Ibitoye¹,

Ukpo²,

Rabiu³

2020

Ann Health Res

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“…Its heartwood is a potential thermal insulator for refrigerators, coolers, and food flask [22]. Aqueous extract from this tree contains active analgesic, anti-hypertensive, and spaspogenic ingredients for administration on rodents [23].…”

Section: Introductionmentioning

confidence: 99%

Recycling of Waste Cartons and Musanga cecropioides Heartwood into Composite Panels for Structural Application

Umoren,

Okorie,

Akaolisa

et al. 2023

Sci. Eng. Technol.

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In this research, the suitability of composite panels developed from waste carton paste (WCP) and Musanga cecropioides heartwood particles (MHP) was assessed for structural applications. Proportions of the MHP adopted were 0, 25, 50, 75, and 100 % by weight of the composite mix. For each formulation, three representative samples were fabricated and also subjected to various tests. The results of the tests showed variations in the mean values of water absorption (8.83 – 30.35 %), thickness swelling (3.72 – 10.84 %), bulk density (342.3 – 461.6 kgm-3), thermal conductivity (0.1166 – 0.1717 Wm-1K-1), thermal diffusivity (2.051 – 2.397 x 10-7 m2s-1), and flexural strength (1.388 – 9.636 MPa) as proportion of the MHP decreased from 100 % to 0 %. On the contrary, a positive correlation was observed in the cases of specific heat capacity (1.552 – 1.661 x 103 Jkg-1K-1) and solar radiation absorptivity (12.32 – 13.32 m-1) with respect to increase in the proportions of the MHP used. Though all the samples exhibited better performance tendencies for thermal insulation compared to conventional ceilings or partition elements used in buildings, it was observed that samples developed with more than 50 % of the MHP could not withstand nailability. Above all, waste cartons and Musanga cecropioides heartwood are promising raw materials to be considered for fabrication of low-cost composite thermal insulation panels suitable for application in building designs. This undertaking could also serve as a safe way of managing them as wastes.

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“…Root sap is used to manage and cure diarrhoea, gonorrhoea, vaginal candidiasis, pulmonary complaints, treatment of upper respiratory tract infection (cough), trypanosomiasis, treatment of dirty wounds and skin diseases, otitis, rheumatism, epilepsy, oedema, and in childbirth. It is also used to cure conjunctivitis, headache and as a laxative(Idu et al, 2009; Ethanol leaf extract have shown anti-inflammatory activity(Sowemimo et al, 2015) while analgesic activity have been reported with both aqueous and ethanol leaf extracts (Aziba and Gbile, 2000;Senjobi et al, 2012;Sowemimo et al, 2015). Anti-hyperglycemic activity of water, ethanol, water-ethanol extracts of Musanga cecropioides stem bark was also recorded(Adeneye et al, 2007; Nyunai et al 2016).…”

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confidence: 99%

“…Several recommendations have been made by few researchers with regards to exploring the pharmacological potentials of Musanga cecropioides. Pharmacological activities recommended for further research include antioxidant activities, hypoglycemic activity, hepatoprotective principle, adrenergic and analgesic effects(Aziba and Gbile, 2000;Adeneye, 2009;Senjobi et al, 2012; Nyunai et al, 2016). To better ascertain the phytochemicals responsible for each pharmacological activity, the need for isolation, identification and purification of phytochemical compounds have suggested(Adeneye, 2009;Senjobi et al, 2012; Nyunai et al, 2016).…”

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confidence: 99%

A MINI-REVIEW ON Musanga cecropioides R. Br. ex Tedlie

Goddidit Esiro Enoyoze,

MacDonald Idu

2023

EPRA

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Musanga cecropioides R. Br. ex Tedlie (family Urticaceae) is a tree distributed across some parts of Africa including Nigeria. Ethnomedicinal surveys of Musanga cecropioides implicate that its various parts are used in the management of several health conditions asides the numerous uses reported ethnobotanically. This review was thus aimed at assessing the extent of work done on Musanga cecropioides parts scientifically in order to identify the gaps that exist in literature. The review revealed the widespread application of Musanga cecropioides parts in the management of cough, diabetes and several other illnesses with little or no scientific work carried out to validate such claims. KEYWORDS: Musanga cecropioides, ethnobotany, ethnomedicine, characteristics and properties.

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Pharmacological screening of Nigerian species of Musanga cecropioides R. Br ex Teddlie (Moraceae) in rodents as anti-hypertensive

Cited by 4 publications

References 3 publications

Qualitative phytochemical screening and antimicrobial evaluation of the total alkaloids of the hydroalcoholic extracts of the leaves and stem bark of Musanga cercropoides (Urticaceae)

Qualitative phytochemical screening and antimicrobial evaluation of the total alkaloids of the hydroalcoholic extracts of the leaves and stem bark of Musanga cercropoides (Urticaceae)

Recycling of Waste Cartons and Musanga cecropioides Heartwood into Composite Panels for Structural Application

A MINI-REVIEW ON Musanga cecropioides R. Br. ex Tedlie

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