Pharmacological significance of biogenic amines in the lungs: histamine

Aviado, Domingo M.; Sadavongvivad, Chiravat

doi:10.1111/j.1476-5381.1970.tb08524.x

Cited by 14 publications

(5 citation statements)

References 19 publications

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“…A compensatory increase in histamine-forming capacity of tissues has been described in guinea-pig anaphylaxis (Kahlson & Rosengren, 1968) and this may be another possible reason for the failure to observe large changes in calf tissue histamine concentration. Aviado & Sadavongvivad (1970) reported that concentrations of both histamine and 5-HT were increased in the lungs of rabbits after anaphylaxis. We have not observed any such increase in calves.…”

Section: Discussionmentioning

confidence: 99%

Acute systemic anaphylaxis in the calf

Eyre

Lewis

Wells

1973

British J Pharmacology

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Summary1. Acute systemic anaphylaxis in calves was characterized by marked systemic hypotension; hypertension in the pulmonary arteries and abdominal vena cava, and transient apnoea. Calves responded with a second reaction to antigen, but a third anaphylactic response could not be evoked. 2. Suppression of systemic anaphylaxis could not be effected with mepyramine, whereas methysergide or diethylcarbamazine each suppressed anaphylaxis by 50%. Disodium cromoglycate alone did not inhibit anaphylaxis: however, when disodium cromoglycate was combined with diethylcarbamazine almost total suppression (85%) was achieved. Sodium meclofenamate also was a powerful inhibitor of anaphylaxis (80%). It is tentatively suggested that slow reacting substance (SRS-A) may be an important mediator of bovine anaphylaxis. 3. Bilateral vagotomy did not modify the circulatory responses to injected histamine, 5-hydroxytryptamine (5-HT) or antigen, whereas the effects of these agents on ventilation (apnoea) were abolished by vagotomy. 4. Plasma histamine concentration was increased during anaphylaxis, whereas plasma 5-HT was not. Whole blood histamine concentration fell sharply and remained depressed during 20 min of anaphylactic shock. Reduced whole blood histamine levels probably reflect the severe leucopoenia in the calves. 5. Histamine concentrations in six tissues taken from calves subjected to anaphylaxis were not different from those in control calves; mast cells were of similar numbers to controls, but showed some swelling, granular spilling and metachromasia.6. Histamine, 5-HT, bradykinin and antigen caused increased pulmonary artery perfusion pressure and ventilation resistance in isolated lungs from sensitized calves. However, there was no difference in histamine and 5-HT concentration in perfusates obtained during antigen infusion of sensitized and control lungs. 7. Systemic anaphylaxis of calves may result from the interaction of histamine, 5-HT and SRS-A. The present data implicate (by indirect measurement) SRS-A as an important mediator of anaphylaxis in this species.

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Section: Discussionmentioning

confidence: 99%

Acute systemic anaphylaxis in the calf

Eyre

Lewis

Wells

1973

British J Pharmacology

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“…In the present study, histamine concentrations in the lung were found to be about 10 times lower than in the initial studies [30,31]. Major strain-specific differences, as observed in the intestine, were absent in the lung, and age-related differences were found in C57Bl/ 6, but not in Balb/c mice.…”

Section: Lungmentioning

confidence: 57%

“…Histamine concentrations in the lung had been analyzed already in 1970 [30], since at that time it was shown that histamine is a central mediator in anaphylaxis, such as in acute allergic asthma. In the present study, histamine concentrations in the lung were found to be about 10 times lower than in the initial studies [30,31].…”

Section: Lungmentioning

confidence: 99%

Systematic analysis of histamine and N-methylhistamine concentrations in organs from two common laboratory mouse strains: C57Bl/6 and Balb/c

et al. 2011

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HPLC-mass spectrometry is a useful method for the highly sensitive and simultaneous detection of histamine and N-methylhistamine. Histamine is present in virtually all organs, not only in those traditionally associated with histamine-mediated disease. Highest concentrations are found in stomach, lymph node, and thymus; medium concentrations in heart, spleen, and kidney; and lowest concentrations detected in intestine, brain, liver, and lung.

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“…1967). Aviado and Sadavongvivad (1970) showed that the concentrations of both histamine and 5-HT were increased in the lungs of rabbits after anaphylaxis. On the other hand we have not observed elevated histamine or 5-HT concentrations in any bovine tissue following cornpsrand 48/80 treatment (this article) or anaphylaxis (unpublished).…”

Section: Discussionmentioning

confidence: 98%

Some Cardiorespiratory Effects of Histamine, 5-Hydroxytryptamine, and Compound 48/80 in the Calf

Lewis¹,

Eyre²

1972

Can. J. Physiol. Pharmacol.

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LEWIS, A. J., and EYRE, P. 1972. Some cnrciiorespiratory eficts of histamine, 5-hydror~ytryptamine, and compoalnd 48/80 in the calf. Can. 9. Playsiol. Phal.maco1. 58, 545-553. Tine cardiorespiratory responses to histamine, -hydroxytryptamine, and cornpourad 48/80 have been examined in the calf. The simultaneous rmeasurement of whole blood histamine and plasma 5-hydroxytryptamine during cc~rraporand 48/80 infusion showed significantly elevated levels that followed a biphaslc pattern. However, mast cell changes i n the sites examined were minimal and there was no significant difference in histarnine concentrations in tissues examined. Marked systemic effects were observed and included an initial rise in femoral arterial blood pressure which was Iater followed by a terminal hypstension and death. Pulmonary arterial blood pressure ant1 venous pressure were both elevated and dyspnoeic respiration was also evident. A combination of ~mepyramine and tnethysergide inhibited the toxicity of compound 48/80 which suggested that histamine and 5-laydroxytryptamine played a major role in the toxic response tes this substance in the calf.

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Pharmacological significance of biogenic amines in the lungs: histamine

Cited by 14 publications

References 19 publications

Acute systemic anaphylaxis in the calf

Acute systemic anaphylaxis in the calf

Systematic analysis of histamine and N-methylhistamine concentrations in organs from two common laboratory mouse strains: C57Bl/6 and Balb/c

Some Cardiorespiratory Effects of Histamine, 5-Hydroxytryptamine, and Compound 48/80 in the Calf

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