Pharmacological Stimulation of Fibrinolytic Activity in the Surgical Patient

Brown, I K; Haggart, B.; Murray, George; Downie, R.; Littler, J. William; Robb, P. M.; Santer, G J

doi:10.1016/s0140-6736(71)91215-3

Cited by 24 publications

(8 citation statements)

References 6 publications

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“…During recent years a number of reports have shown that plasma cortisol levels and blood fibrinolytic activity fluctuate during major surgery. Anaesthesia and surgery cause a definite increase of plasma cortisol (Virtue and Helmreich, 1957;Hammond et al, 1958;Oyama et al, 1968;Plumpton, Besser and Cole, 1969) and also cause increased blood fibrinolytic activity (MacFarlane and Biggs, 1946;von Kaulla, 1947;Andersson, Nilsson and Olow, 1962;Mansfield, 1970;Brown et al, 1971). Although plasma cortisol levels and blood fibrinolytic activity may thus be related, to our knowledge they have never been investigated simultaneously during stress.…”

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confidence: 99%

Variations of Plasma Cortisol and Blood Fibrinolytic Activity During Anaesthetic and Surgical Stress

Engquist

Winther

1972

British Journal of Anaesthesia

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Blood fibrinolytic activity and plasma cortisol levels were investigated during surgical procedures in twenty-three patients who underwent laparotomy. From 30 minutes to 1^ hours of surgical stress, enhancement of fibrinolysis was significantly correlated with increase of plasma cortisol levels. There were no exceptions to this pattern. The changes in fibrinolytic activity and plasma cortisol levels were found to depend mainly on the surgical stress. There was no difference with regard to the various anaesthetics employed.

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confidence: 99%

Variations of Plasma Cortisol and Blood Fibrinolytic Activity During Anaesthetic and Surgical Stress

Engquist

Winther

1972

British Journal of Anaesthesia

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“…The clinical implications of these studies include reduced mortality and morbidity for brain tumor patients and improved results of therapy. Enhancement of systemic fibrinolysis either pharmacologically or by the use of intermittent compression devices may be a rational way to provide adequate monitoring and prophylaxis against these life-threatening complications [11,[20][21][22].…”

Section: Discussionmentioning

confidence: 99%

Postoperative venous thromboembolism and brain tumors: part III. Biochemical profile

Sawaya

Highsmith

1992

J Neuro-Oncol

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The plasminogen activator activity of 31 human brain tumor samples was assessed and the results correlated with clinical parameters and the postoperative occurrence of venous thrombosis. A significant negative correlation was found between plasminogen activator activity and venous thrombosis (P = 0.02), while positive correlations were observed between plasminogen activator activity and peritumoral brain edema (P = 0.03) and alpha2 antiplasmin measured in the systemic circulation (P = 0.01). Tissue plasminogen activator was found in higher concentrations in meningioma tissue but did not correlate significantly with the occurrence of venous thrombosis. The results of this study suggest a local enzymatic degradation effect of plasminogen activator on thrombogenic substances present in the brain tumor and/or its environment.

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“…Efforts to improve fibrinolytic mechanisms with phenformin and ethyloestrenol were made too late to have contributed either to his gut bleeding or to the maintenance of patency of his remaining arterial circulation (Fearnley, Chakrabarti & Hocking, 1967;Chakrabarti et al, 1968;Brown et al, 1971).…”

Section: Discussionmentioning

confidence: 99%