Pharmacological studies on ginger. IV Effect of (6)-shogaol on the arachidonic cascade.

Suekawa, Mamoru; Yuasa, Kazunori; Isono, Masanao; Sone, Hideko; Ikeya, Yukinobu; Sakakibara, Iwao; Aburada, Masaki; Hosoya, Eikichi

doi:10.1254/fpj.88.263

Cited by 23 publications

(14 citation statements)

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“…23) Since the decrease in Ca spike frequency induced by Ca antagonists was well matched to the relaxation from resting tension in guinea pig taenia coli, 24) the Ca antagonistic effect of [6]-gingerol may be involved in the inhibitory effect of Dai-kenchu-to at high concentrations. In addition, it has been suggested that there is an inhibitory effect of [6]-gingerol or [6]-shogaol on COX in vivo and in vitro, 25,26) and that PGs contribute to peristaltic activity via a direct action on the muscle cells and stimulating nerves. 27) Since it was confirmed that PGs were involved in the present models, the inhibition of COX may contribute to the inhibitory effects of dried ginger root on accelerated small intestinal motility.…”

Section: Effect On Isolated Guinea Pig Ileummentioning

confidence: 99%

Dai-kenchu-to Enhances Accelerated Small Intestinal Movement.

Satoh

Kase

Hayakawa

et al. 2001

Biological & Pharmaceutical Bulletin

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Section: Effect On Isolated Guinea Pig Ileummentioning

confidence: 99%

Dai-kenchu-to Enhances Accelerated Small Intestinal Movement.

Satoh

Kase

Hayakawa

et al. 2001

Biological & Pharmaceutical Bulletin

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“…[6]-Shogaol was shown, among other effects, to have a central nervous system-suppressing effect [3], an effect on arachidonic acid metabolism [4], a prostaglandin formation-inhibiting effect [5], a small intestine blood flowincreasing effect [6], a small intestine peristaltic motionpromoting effect [7]. Its main metabolite [6]-paradol was also shown to have a bactericidal effect [8] and activator protein 1 activity [9].…”

Section: Introductionmentioning

confidence: 99%

Pharmacokinetics of [6]-shogaol, a pungent ingredient of Zingiber officinale Roscoe (Part I)

et al. 2010

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To investigate the pharmacokinetics of [6]-shogaol, a pungent ingredient of Zingiber officinale Roscoe, the pharmacokinetic parameters were determined by using (14)C-[6]-shogaol (labeled compound) and [6]-shogaol (non-labeled compound). When the labeled compound was orally administered to rats, the maximum plasma concentration (C (max)) and the area under the curve (AUC) of plasma radioactivity concentration increased in a dose-dependent manner. When the labeled compound was orally administered at a dose of 10 mg/kg, 20.0 + or - 1.8% of the radioactivity administered was excreted into urine, 64.0 + or - 12.9% into feces, and 0.2 + or - 0.1% into breath. Thus, more of the radioactivity was excreted into feces than into urine, and almost no radioactivity was excreted into breath. Furthermore, when the labeled compound was orally administered at a dose of 10 mg/kg, cumulative biliary radioactivity excretion over 48 h was 78.5 + or - 4.5% of the radioactivity administered, and cumulative urinary radioactivity excretion over 48 h was 11.8 + or - 2.7%, showing that about 90% of the dose administered orally was absorbed from the digestive tract and most of the fecal excretion was via biliary excretion. On the other hand, when the non-labeled compound [6]-shogaol was orally administered, the plasma concentration and biliary excretion of the unchanged form were extremely low. When these results are combined with those obtained with the labeled compound, it would suggest that [6]-shogaol is mostly metabolized in the body and excreted as metabolites.

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“…Thus, PGE2 enhances intestinal peristalsis, inhibits Na + absorption by interfering with the Na + , K + -ATPase activity, enhances Cl -secretion, and reduces water absorption, leading to diarrhea 14,15) . Evidence has been presented that Glycyrrhizae Radix and Zingiberis Scicatum Rhizoma, which are components of HST, suppress PGE2 [16][17][18] . Moreover, Vento et al (2011) reported that Cyclooxygenase-2 (COX-2) expression is positively correlated with mucosal atrophy in patients with chronic pouchitis 19) .…”

Section: Discussionmentioning

confidence: 99%

The Use of Oral Herbal Medicine (Hange-Shashin-To) in Patients with Pouchitis: A Pilot Study

Matsuoka

Uchino

Horio

et al. 2018

J Anus Rectum Colon

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Abstract:Objectives: Hange-Shashin-To (HST), which is a combination of seven herbs, has previously been used in the treatment of inflammatory or ulcerative gut disease. The aim of this study was to evaluate the safety and efficacy of HST for the treatment of chronic pouchitis. Methods: Nineteen patients with chronic pouchitis, defined as either frequent episodes (!three episodes per six months) of pouchitis or persistent symptoms that required continuous antibiotic therapies, were selected and treated with ciprofloxacin (CPFX) 600 mg/day for 2 weeks (week 0~2) and HST 3,750 mg/day for 32 weeks (week 0~32). The Pouchitis Disease Activity Index (PDAI) score was measured at week 0 and 6 for short-term evaluation. For long-term evaluation, total CPFX dose in the 26-week period prior to study entry (from 30 weeks before study entry to 5 weeks before study entry) was compared with the total CPFX dose during the 26-week study period (week 7~32). Although no concomitant administration of CPFX was permitted from week 2-6, patients whose condition deteriorated were prescribed CPFX from week 7 to week 32. Results: Fourteen patients completed this 32-week study. The PDAI scores of eight patients decreased below seven. The mean total PDAI scores decreased significantly from 11 ± 2.5 to 6.5 ± 2.5 (P < 0.001). The mean value of total CPFX dose decreased significantly from 491.6 ± 182.4 mg/kg to 392.5 ± 184.0 mg/kg (P < 0.05). No severe adverse events were noted. Conclusions: Our data suggest that HST has a positive effect on chronic pouchitis with no adverse effects.

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Pharmacological studies on ginger. IV Effect of (6)-shogaol on the arachidonic cascade.

Cited by 23 publications

References 0 publications

Dai-kenchu-to Enhances Accelerated Small Intestinal Movement.

Dai-kenchu-to Enhances Accelerated Small Intestinal Movement.

Pharmacokinetics of [6]-shogaol, a pungent ingredient of Zingiber officinale Roscoe (Part I)

The Use of Oral Herbal Medicine (Hange-Shashin-To) in Patients with Pouchitis: A Pilot Study

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