Pharmacology of Ruvettus Pretiosus, or "Castor-Oil Fish."

Macht, David I.; Barba-Gose, J.

doi:10.3181/00379727-28-5526

Cited by 9 publications

(7 citation statements)

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“…Gastrointestinal Eflects.-The charcoal meal test introduced by Macht and Barba-Gose (1931) for examining cathartics and used by Karr (1947) in testing the effects of morphine, methadone and pethidine, was investigated. The rats were prepared in two ways.…”

Section: Methodsmentioning

confidence: 99%

Comparative Effects of Analgesics on Pain Threshold, Respiratory Frequency and Gastrointestinal Propulsion

Green

1959

British Journal of Pharmacology and Chemotherapy

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In the rat, the ratio of the analgesic to the respiratory depressant potency was the same for morphine, codeine, diamorphine, methadone, dipipanone, piperidylisomethadone, phenadoxone, dextromoramide, and propoxyphene. The relative respiratory depressant activity of pethidine tended to be less, but the difference was not significant. The ratio of the analgesic dose to the dose preventing transport of a charcoal meal in the rat was about the same for morphine, codeine, pethidine, methadone, phenadoxone, dimethylthiambutene, and propoxyphene; the relative activities of these compounds in inhibiting the peristaltic reflex of the isolated guinea-pig ileum were also similar. However, because of differences in the slopes of regression lines in the charcoal meal test, some compounds (for example, morphine) had a greater effect on gastrointestinal propulsion than others (for example, pethidine) when given at moderate analgesic dose levels.In studies of the effects of intracisternal morphine in the rat, effects on the spinal reflex of the tail were to some extent dissociated from effects on the threshold for a squeak response. Further, the delaying of transport of a charcoal meal paralleled depression of respiratory rate, and this is evidence for the participation of a central as well as a peripheral action in the effect of morphine on the gastrointestinal tract. The delay in propulsion was reduced by nalorphine and increased by atropine and two general anaesthetic substances, but was unaffected by a number of other pharmacological agents.

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Section: Methodsmentioning

confidence: 99%

Comparative Effects of Analgesics on Pain Threshold, Respiratory Frequency and Gastrointestinal Propulsion

Green

1959

British Journal of Pharmacology and Chemotherapy

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“…Treatment with reserpine has been shown (6) to diminish the spasmogenic effect of morphine on the dog small intestine, but no study of the influence of prior treatment with reserpine on the actions of morphine on propulsive activity of the intestine has been made. All chemical agents and saline were administered intraperitoneally to the animals in volumes of 0.01 ml/g and their effects on gastrointestinal propulsion assayed by the method of Macht and Barba-Gme (8). and physostigmine on morphine and 5-HT actioas on propulsive activity oS the small intestine of lthe mouse, to evaluate the effects of reserpine treatment on the response tol morphine and to determine whether a 5-HT antagonist, methysergide (UML) , would alter intestinal responses to morphine.…”

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confidence: 99%

Additional Evidence for the Participation of 5-Hydroxytryptamine in The Intestinal Response to Morphine.

Burks

Long

1967

Experimental Biology and Medicine

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“…Removal of the oxadiazole (14), substitution by carboxamide (15) or dimethylcarboxamide (16), or substitution on one of the phenyl groups (21, 22) was not beneficial to activity. Substituting a phenyl by 2-pyridyl (19) caused a slight decrease in potency, while the 3-pyridyl analogue 20 caused a significant decrease.…”

Section: Discussionmentioning

confidence: 99%

3,3-Diphenyl-3-(2-alkyl-1,3,4-oxadiazol-5-yl)propylcycloalkylamines, a novel series of antidiarrheal agents

Adelstein¹,

Yen²,

Dajani³

et al. 1976

J. Med. Chem.

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A series of 4-amino-2,2-diarylbutyronitriles (3) prepared for testing as inhibitors of gastrointestinal propulsive activity did not show any enhancement over such existing agents as diphenoxylate and loperamide. However, conversion of the nitrile group to a 2-methyl-1,3,4-oxadiazol-5-yl function led to compounds 5g and 5j, statistically equipotent to diphenoxylate and loperamide in the mouse and showing a very low order of analgesic activity. Structural modifications determined that the best separation of antipropulsive and analgesic effects was obtained when the amino group was bicyclic and the oxadiazole ring had a 2-methyl substituent. The most potent compounds were and analogues of diphenoxylate and loperamide where the oxadiazole ring was present, but these compounds had marked analgesic activity.

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Pharmacology of Ruvettus Pretiosus, or "Castor-Oil Fish."

Cited by 9 publications

References 0 publications

Comparative Effects of Analgesics on Pain Threshold, Respiratory Frequency and Gastrointestinal Propulsion

Comparative Effects of Analgesics on Pain Threshold, Respiratory Frequency and Gastrointestinal Propulsion

Additional Evidence for the Participation of 5-Hydroxytryptamine in The Intestinal Response to Morphine.

3,3-Diphenyl-3-(2-alkyl-1,3,4-oxadiazol-5-yl)propylcycloalkylamines, a novel series of antidiarrheal agents

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