Pharmacology of Sulfadiazine Silver

Syntheses, Crystal Structures, and Cytotoxicity Evaluation of two Chain‐like and Diamond‐like Silver(I) Complexes

“…Silver sulfadiazine [6] (AgSD), have been used as the standard treatment for burns more than 20 years. It is suggested that the basic function of the almost insoluble AgSD may be the slow release of silver into the superficial wound environment [7]. Silver is by far the less investigated coinage metal in coordination chemistry, which possibly be attributed to the poor solubility of silver(I) compounds in common solvents and the sensitivity toward photodecomposition [8].…”

A novel structure of silver polymer through Na–O bonds with cytotoxicity property

“…Silver sulfadiazine [3] (AgSD), have been used as the standard treatment for burns more than 20 years. It is suggested that the basic function of the almost insoluble AgSD may be the slow release of silver into the superficial wound environment [4]. According to the research results we reported [5], we believe that the silver(I) sulphonate complex 1 may be a good compound showing strong cytotoxicity in vitro.…”

Silver

“…In particular, there is concern that SSD may pass into the bloodstream and be distributed systemically (Tsipsouras et al 1997). Most studies have shown that very little silver is transported beyond the superficial layer of the wound (Harrison 1979), though some studies have demonstrated the potential for silver ion transport and subsequent toxicity (Sun et al 1994).…”

“…Although silver nitrate solution would play a similar bacteriostatic role, its undesirable side effects limit its use (Monafo and West 1990). A development in such treatment has been the use of a silver-nylon cloth as an alternative to sulfadiazene (Harrison 1979). Both in vitro and in vivo studies have demonstrated the efficacy of this material, which has the advantage over sulfadiazene cream, in that stimulation by a small electric current allows some control over the release of silver ions from the cloth.…”