Pharmacology of Sulphonamides: Recent Work

Penicillin Cream of Low Concentration

“…Some observations on the absorption from the intestine can be explained if it is assumed that absorption is facilitated by the ionization of the sulphonamide group. Sulphapyridine has been reported to be absorbed more slowly, less regularly, and less completely than sulphathiazole and sulphadiazine (see Hawking, 1945). At the pH prevailing in the small intestine sulphapyridine is largely un-ionized, while sulphathiazole and sulphadiazine are mainly present as anions.…”